LOCUS BC003053 2040 bp mRNA linear HUM 06-APR-2004
DEFINITION Homo sapiens guanosine monophosphate reductase 2, mRNA (cDNA clone
MGC:830 IMAGE:3546620), complete cds.
ACCESSION BC003053
VERSION BC003053.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2040)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2040)
AUTHORS Strausberg,R.
TITLE Direct Submission
JOURNAL Submitted (06-FEB-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Cancer Genomics Office, National Cancer
Institute, 31 Center Drive, Room 11A03, Bethesda, MD 20892-2590,
USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Steve Jones, Sarah Barber, Mabel Brown-John, Yaron Butterfield,
Andy Chan, Steve S. Chand, William Chow, Alison Cloutier, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Amara Masson, Mike R. Mayo, Josh Moran, Ryan Morin,
Teika Olson, Diana Palmquist, Anca Petrescu, Anna Liisa Prahbu,
Parvaneh Saeedi, JR Santos, Angelique Schnerch, Ursula Skalska,
Duane Smailus, Jeff Stott, Miranda Tsai, George Yang, Jacquie
Schein, Asim Siddiqui, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 8 Row: n Column: 14
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 20070275.
FEATURES Location/Qualifiers
source 1..2040
/db_xref="H-InvDB:HIT000258898"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:830 IMAGE:3546620"
/tissue_type="Placenta, choriocarcinoma"
/clone_lib="NIH_MGC_21"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2040
/gene="GMPR2"
/db_xref="GeneID:51292"
CDS 332..1561
/gene="GMPR2"
/codon_start=1
/product="GMPR2 protein"
/protein_id="AAH03053.1"
/db_xref="GeneID:51292"
/translation="MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQT
YSGVPIIAANMDTVGTFEMAKVLCKFSLFTAVHKHYSLVQWQEFAGQNPDCLEHLAAS
SGTGSSDFEQLEQILEAIPQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVV
TGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIIS
DGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMK
KYAGGVAEYRYVWRPRSLVIVWRQNSWLLRGGWYSSQRSMVNRGSMLGSVEKSLGLRN
PEGEDNKVFPTLRASEGKTVEVPFKGDVEHTIRDILGGIRSTCTYVGAAKLKELSRRT
TFIRVTQQVNPIFSEAC"
misc_feature 359..595
/gene="GMPR2"
/note="IMPDH; Region: IMP dehydrogenase / GMP reductase
domain. This family is involved in biosynthesis of
guanosine nucleotide. Members of this family contain a TIM
barrel structure. In the inosine monophosphate
dehydrogenases 2 CBS domains pfam00571 are inserted in the
TIM barrel. This family is a member of the common
phosphate binding site TIM barrel family"
/db_xref="CDD:pfam00478"
misc_feature 593..1540
/gene="GMPR2"
/note="IMPDH; Region: IMP dehydrogenase / GMP reductase
domain. This family is involved in biosynthesis of
guanosine nucleotide. Members of this family contain a TIM
barrel structure. In the inosine monophosphate
dehydrogenases 2 CBS domains pfam00571 are inserted in the
TIM barrel. This family is a member of the common
phosphate binding site TIM barrel family"
/db_xref="CDD:pfam00478"
BASE COUNT 544 a 467 c 543 g 486 t
ORIGIN
1 atcagcctct tgccccattg ctctttgcag gggtagaaga aggaagtgta gcggggtaag
61 gaatgcaccg tcagggtctc tcacaaccct ttcccagctc tcctccccaa caaacagtac
121 ctgggatgga gccctagggt aatcgcagcc acgggatggg tcgaggtgac aggcttcagg
181 gaccacactt cggcctttgc ccgaccttcc acaacttaag cgaagagagg ccaccagccg
241 taacagggcg ttaaagccca ggggaagatt ggtccttatg acttcctgcc ttccagccct
301 cagattcatc gctaccccga ggctaagcgc catgcctcat attgacaacg atgtgaaact
361 ggacttcaag gatgtccttt tgaggcccaa acgcagtacc cttaagtctc gaagtgaggt
421 ggatctcaca agatcctttt catttcggaa ctcaaagcag acatactctg gggttcccat
481 cattgctgcc aatatggata ctgtgggcac ctttgagatg gccaaggttc tctgtaagtt
541 ctctctcttc actgctgtcc ataagcacta tagcctcgtt cagtggcaag agtttgctgg
601 ccagaatcct gactgtcttg agcatctggc tgccagctca ggcacaggct cttctgactt
661 tgagcagctg gaacagatcc tggaagctat tccccaggtg aagtatatat gcctggatgt
721 ggcaaatggc tactctgaac actttgttga atttgtaaaa gatgtacgga agcgcttccc
781 ccagcacacc atcatggcag ggaatgtggt aacaggagag atggtagaag agctcatcct
841 ttctggggct gacatcatca aagtgggaat tgggccaggc tctgtgtgta ctactcggaa
901 gaaaactgga gtggggtatc cacagctcag cgcagtgatg gagtgtgcag atgctgctca
961 tggcctcaaa ggccacatca tttcagatgg aggttgcagc tgtcctgggg atgtggccaa
1021 ggcttttggg gcaggagctg acttcgtgat gctgggtggc atgctggctg ggcacagtga
1081 gtcaggtggt gagctcatcg agagggatgg caagaagtac aagctcttct atggaatgag
1141 ttctgaaatg gccatgaaga agtatgctgg gggcgtggct gagtacaggt atgtgtggag
1201 gcccaggagc ttagtaatag tatggaggca gaactcatgg ctgctgagag ggggatggta
1261 cagttctcag agaagcatgg tgaaccgggg ctcaatgcta gggtctgtgg aaaagtccct
1321 gggcttaagg aatccagaag gagaagataa taaagttttt cctactttaa gagcctcaga
1381 gggaaagaca gtggaagttc cttttaaagg agatgtggaa cataccatcc gagacatcct
1441 aggagggatc cgctctacgt gtacctatgt gggagcagct aagctcaaag agttgagcag
1501 gagaactacc ttcatccgag tcacccagca ggtgaatcca atcttcagtg aggcgtgcta
1561 gacctgagca gttctaccct cccaaggcac cagtactcta ccatggggca tcccaagtgg
1621 ggtcctcacc catcccagct actgcagctc tgtattactt tgtcatttcc tgttgtctca
1681 ctcctgaggg ctcctgcagt aactctgtac ttctctatct gcacacacaa aatgcccaag
1741 gcactcactg gggaggaagc aaggaagcaa acagtctgag aaaatgatgc aagaaaatca
1801 aatgggaatc tggggaccca acacaacatc ctgaagatta ttaaaaggaa aagatgctga
1861 ttggtacata aatcttttac atggccttgg tctagaggag gcaggctttt agaatcatgt
1921 tttgttaatc cgcttcacta aattggacct tcacatatct aaaaagctct gaagtgtttg
1981 tatatttgaa atacctcaat aaagagagag ctcattgact gtaaaaaaaa aaaaaaaaaa
//