LOCUS BC002363 3973 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 2,
mRNA (cDNA clone MGC:8629 IMAGE:2961482), complete cds.
ACCESSION BC002363
VERSION BC002363.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3973)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3973)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (05-FEB-2001) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 19, 2003 this sequence version replaced BC002363.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 1 Row: m Column: 20
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 56243487.
FEATURES Location/Qualifiers
source 1..3973
/db_xref="H-InvDB:HIT000030830"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:8629 IMAGE:2961482"
/tissue_type="Muscle, rhabdomyosarcoma"
/clone_lib="NIH_MGC_17"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3973
/gene="RPS6KA2"
/gene_synonym="HU-2"
/gene_synonym="MAPKAPK1C"
/gene_synonym="p90-RSK2"
/gene_synonym="pp90RSK3"
/gene_synonym="RSK"
/gene_synonym="RSK3"
/gene_synonym="S6K-alpha"
/gene_synonym="S6K-alpha2"
/db_xref="GeneID:6196"
/db_xref="HGNC:HGNC:10431"
/db_xref="MIM:601685"
CDS 219..2420
/gene="RPS6KA2"
/gene_synonym="HU-2"
/gene_synonym="MAPKAPK1C"
/gene_synonym="p90-RSK2"
/gene_synonym="pp90RSK3"
/gene_synonym="RSK"
/gene_synonym="RSK3"
/gene_synonym="S6K-alpha"
/gene_synonym="S6K-alpha2"
/codon_start=1
/product="ribosomal protein S6 kinase, 90kDa, polypeptide
2"
/protein_id="AAH02363.1"
/db_xref="GeneID:6196"
/db_xref="HGNC:HGNC:10431"
/db_xref="MIM:601685"
/translation="MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEEEGVVKEIDIS
HHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRD
RVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEED
VKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYS
FCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKL
GMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPP
FKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDL
HKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSK
RDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSERE
ASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNG
LLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILA
RIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQ
LSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL"
BASE COUNT 816 a 1145 c 1205 g 807 t
ORIGIN
1 cggagaagga ggcggaggga gcgattgtgg ccccggccgc ggtggccggc gcggcctgcc
61 ctttgtgacc gcagctcgcg ccccacgccc cgcgcccatg gccgccgtgc cgggctccct
121 ggccacgcgt gcccgcccgc ggacctgagc cccgcgcctg ggatgccggg gatgcgcgtc
181 ccccggccct gcggctgctc cgggctgggc gcggggcgat ggacctgagc atgaagaagt
241 tcgccgtgcg caggttcttc tctgtgtacc tgcgcaggaa gtcgcgctcc aagagctcca
301 gcctgagccg gctcgaggaa gaaggtgtcg tgaaggagat agacatcagc catcatgtga
361 aggagggctt tgagaaggca gatccttccc agtttgagct gctgaaggtt ttaggacaag
421 gatcctatgg aaaggtgttc ctggtgagga aggtgaaggg gtccgacgct gggcagctct
481 acgccatgaa ggtccttaag aaagccaccc taaaagttcg ggaccgagtg agatcgaaga
541 tggagagaga catcttggca gaagtgaatc accccttcat tgtgaagctt cattatgcct
601 ttcagacgga aggaaagctc tacctgatcc tggacttcct gcggggaggg gacctcttca
661 cccggctctc caaagaggtc atgttcacgg aggaggatgt caagttctac ctggctgagc
721 tggccttggc tttagaccat ctccacagcc tggggatcat ctacagagat ctgaagcctg
781 agaacatcct cctggatgaa gaggggcaca ttaagatcac agatttcggc ctgagtaagg
841 aggccattga ccacgacaag agagcgtact ccttctgcgg gacgatcgag tacatggcgc
901 ccgaggtggt gaaccggcga ggacacacgc agagtgccga ctggtggtcc ttcggcgtgc
961 tcatgtttga gatgctcacg gggtccctgc cgttccaggg gaaggacagg aaggagacca
1021 tggctctcat cctcaaagcc aagctgggga tgccgcagtt cctcagtggg gaggcacaga
1081 gtttgctgcg agctctcttc aaacggaacc cctgcaaccg gctgggtgct ggcattgacg
1141 gagtggagga aattaagcgc catcccttct ttgtgaccat agactggaac acgctgtacc
1201 ggaaggagat caagccaccg ttcaaaccag cagtgggcag gcctgaggac accttccact
1261 ttgaccccga gttcacagcg cggacgccca cagactctcc tggcgtcccc ccgagtgcaa
1321 acgctcatca cctgtttaga ggattcagct ttgtggcctc aagcctgatc caggagccct
1381 cacagcaaga tctgcacaaa gtcccagttc acccaatcgt gcagcagtta cacgggaaca
1441 acatccactt caccgatggc tacgagatca aggaggacat cggggtgggc tcctactcag
1501 tgtgcaagcg atgtgtgcat aaagccacag acaccgagta tgccgtgaag atcattgata
1561 agagcaagag agacccctcg gaagagattg agatcctcct gcggtacggc cagcacccga
1621 acatcatcac cctcaaggat gtctatgatg atggcaagtt tgtgtacctg gtaatggagc
1681 tgatgcgtgg tggggagctc ctggaccgca tcctccggca gagatacttc tcggagcgcg
1741 aagccagtga cgtcctgtgc accatcacca agaccatgga ctacctccat tcccaggggg
1801 ttgttcatcg agacctgaag ccgagtaaca tcctgtacag ggatgagtcg gggagcccag
1861 aatccatccg agtctgcgac ttcggctttg ccaagcagct gcgcgcgggg aacgggctgc
1921 tcatgacacc ctgctacacg gccaatttcg tggccccgga ggtcctgaag cgtcaaggct
1981 atgatgcggc gtgtgacatc tggagtttgg ggatcctgtt gtacaccatg ctggcaggat
2041 ttaccccttt tgcaaatggg ccagacgata cccctgagga gattctggcg cggatcggca
2101 gtgggaagta tgccctttct gggggaaact gggactcgat atctgacgca gctaaagacg
2161 tcgtgtccaa gatgctccac gtggaccctc atcagcgcct gacggcgatg caagtgctca
2221 aacacccgtg ggtggtcaac agagagtacc tgtccccaaa ccagctcagc cgacaggacg
2281 tgcacctggt gaagggcgcg atggccgcca cctactttgc tctaaacaga acacctcagg
2341 ccccgcggct ggagcccgtg ctgtcgtcca acctggctca gcgcagaggc atgaagagac
2401 tcacgtccac gcggttgtag cgggtgggac cctggcccca gcgtcccctg ccagcatcct
2461 cgtgggctca cagaccccgg cctcggagcc cgtctggcac ccagagtgac cacaagtcca
2521 gcagggaggc ggcgcccgcc ctcgccgtgt ccgtgttttc tttttcagcc ccggagaggg
2581 tcctgacctg ggggcttctc caagcctcac tgcgccagcc tccccgcccg ctctcttttc
2641 tcccaagcaa aaccaaatgc gccccttcac ctcgcgtgcc cgtgcgaggc cgggggcttc
2701 tttcagagcc cgcgggtcct ctcatacatg gcttctgttt ctgccgagag atctgttttc
2761 caattatgaa gccggtcggt ttggtcagac tcccgacacc cacgtcccag gtacccggtg
2821 ggaaagtggc agtgcgaggg cgcagccatt ggtggttgca gggccccaga gggctggggt
2881 gacctggcat cccggggctc cccacgggct ggatgacggg gttggcactg tggcgtccag
2941 gaggagatgc ctggttctgc ccaaaataat ccaaagagcc gtttcctcct cgcccttcag
3001 tttttgcctg aggtgctggg tagcccatcc tttcctctgt cccagattca aatgaggagt
3061 aagagcccag acgagaggaa ggcaggctgg atctttgcct tgagagctcc gtgtcaccag
3121 gatggaaggg ggtgcctctc ggaggagcct gtgtccacct ccagtctcgg ctttccccgg
3181 ggggccaagc gcactgggct gccgtctgtc cccagctccc gtggccacac agctatctgg
3241 aggctttgca gggagtcgtg ggttctcgca cctgctcagc cctgtgtcgg cttcctgtgt
3301 gctcacctaa agctgtggtt ttgctgtgtt cacttcgatt tttctggtct gtggagaaac
3361 tgtgaattgg agaaatggag ctctgtggct tcccacccaa accttctcag tccagctgga
3421 ggctggaggg agacacaggc cccacccagc agactgaggg gcagaggcac aggtgggagg
3481 gcagcggaga tcagcgtgga caggagcgat gcactttgta gatgctgtgg ctttgtgttg
3541 cgttttgtgt ctctgttgca cagatctgtt ttttcacact gatccgtatt cccctgggtg
3601 tgcacacagg gcgggtgtgg ggcatttagg ccatgctgtg ctctacttca ttgagtaaaa
3661 tcgagtgaga ggttccgggc agcaggatcg acgcccagtc cagccggcag agggaacaca
3721 cgggtccttc attgtcctgt aagggtgttg aagatgctcc ctggcggccc ccaagcagac
3781 tagatgggag gaggcgccgc tcagcccctc accctgcatc actgaagagc ggcgcctctg
3841 cagcaagcag ggcttcagga ggtgcccgct ggccacagcc aggttttccc taagaagatg
3901 ttattttgtt gggttttgtt ccccctccat ctcgattctc gtacccaact aaaaaaaaaa
3961 aaaaaaaaaa aaa
//