LOCUS BC000633 2984 bp mRNA linear HUM 15-JUL-2006
DEFINITION Homo sapiens TTK protein kinase, mRNA (cDNA clone MGC:865
IMAGE:3343925), complete cds.
ACCESSION BC000633
VERSION BC000633.2
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2984)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 2984)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (15-NOV-2000) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT On Aug 20, 2003 this sequence version replaced BC000633.1.
Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: National Institutes of Health Intramural
Sequencing Center (NISC),
Gaithersburg, Maryland;
Web site: http://www.nisc.nih.gov/
Contact: nisc_mgc@nhgri.nih.gov
Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B.,
Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S.,
Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P.,
Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R.,
Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C.,
McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W.,
Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L.,
Young,A., Zhang,L.-H. and Green,E.D.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 5 Row: d Column: 11
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 34303964.
FEATURES Location/Qualifiers
source 1..2984
/db_xref="H-InvDB:HIT000029791"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:865 IMAGE:3343925"
/tissue_type="Eye, retinoblastoma"
/clone_lib="NIH_MGC_16"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..2984
/gene="TTK"
/gene_synonym="ESK"
/gene_synonym="MPS1L1"
/gene_synonym="PYT"
/db_xref="GeneID:7272"
/db_xref="HGNC:HGNC:12401"
/db_xref="MIM:604092"
CDS 75..2648
/gene="TTK"
/gene_synonym="ESK"
/gene_synonym="MPS1L1"
/gene_synonym="PYT"
/codon_start=1
/product="TTK protein kinase"
/protein_id="AAH00633.1"
/db_xref="GeneID:7272"
/db_xref="HGNC:HGNC:12401"
/db_xref="MIM:604092"
/translation="MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISAD
TTDNSGTVNQIMMMANNPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDK
YGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVK
KSKQLLQKAVERGAVPLEMLEIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGS
LGHLQNRNNSCDSRGQTTKARFLYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPV
NLLNSPDCDVKTDDSVVPCFMKRQTSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSH
FKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQWQSKRK
SECINQNPAASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSI
CKTPSSNTLDDYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQV
LASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLD
SYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWER
KSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDS
QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQ
ISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPV
NQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHNSSSSKTFEKKRGK
K"
BASE COUNT 1069 a 525 c 555 g 835 t
ORIGIN
1 ggaaattcaa acgtgtttgc ggaaaggagt ttgggttcca tcttttcatt tccccagcgc
61 agctttctgt agaaatggaa tccgaggatt taagtggcag agaattgaca attgattcca
121 taatgaacaa agtgagagac attaaaaata agtttaaaaa tgaagacctt actgatgaac
181 taagcttgaa taaaatttct gctgatacta cagataactc gggaactgtt aaccaaatta
241 tgatgatggc aaacaaccca gaggactggt tgagtttgtt gctcaaacta gagaaaaaca
301 gtgttccgct aagtgatgct cttttaaata aattgattgg tcgttacagt caagcaattg
361 aagcgcttcc cccagataaa tatggccaaa atgagagttt tgctagaatt caagtgagat
421 ttgctgaatt aaaagctatt caagagccag atgatgcacg tgactacttt caaatggcca
481 gagcaaactg caagaaattt gcttttgttc atatatcttt tgcacaattt gaactgtcac
541 aaggtaatgt caaaaaaagt aaacaacttc ttcaaaaagc tgtagaacgt ggagcagtac
601 cactagaaat gctggaaatt gccctgcgga atttaaacct ccaaaaaaag cagctgcttt
661 cagaggagga aaagaagaat ttatcagcat ctacggtatt aactgcccaa gaatcatttt
721 ccggttcact tgggcattta cagaatagga acaacagttg tgattccaga ggacagacta
781 ctaaagccag gtttttatat ggagagaaca tgccaccaca agatgcagaa ataggttacc
841 ggaattcatt gagacaaact aacaaaacta aacagtcatg cccatttgga agagtcccag
901 ttaaccttct aaatagccca gattgtgatg tgaagacaga tgattcagtt gtaccttgtt
961 ttatgaaaag acaaacctct agatcagaat gccgagattt ggttgtgcct ggatctaaac
1021 caagtggaaa tgattcctgt gaattaagaa atttaaagtc tgttcaaaat agtcatttca
1081 aggaacctct ggtgtcagat gaaaagagtt ctgaacttat tattactgat tcaataaccc
1141 tgaagaataa aacggaatca agtcttctag ctaaattaga agaaactaaa gagtatcaag
1201 aaccagaggt tccagagagt aaccagaaac agtggcaatc taagagaaag tcagagtgta
1261 ttaaccagaa tcctgctgca tcttcaaatc actggcagat tccggagtta gcccgaaaag
1321 ttaatacaga gcagaaacat accacttttg agcaacctgt cttttcagtt tcaaaacagt
1381 caccaccaat atcaacatct aaatggtttg acccaaaatc tatttgtaag acaccaagca
1441 gcaatacctt ggatgattac atgagctgtt ttagaactcc agttgtaaag aatgactttc
1501 cacctgcttg tcagttgtca acaccttatg gccaacctgc ctgtttccag cagcaacagc
1561 atcaaatact tgccactcca cttcaaaatt tacaggtttt agcatcttct tcagcaaatg
1621 aatgcatttc ggttaaagga agaatttatt ccattttaaa gcagatagga agtggaggtt
1681 caagcaaggt atttcaggtg ttaaatgaaa agaaacagat atatgctata aaatatgtga
1741 acttagaaga agcagataac caaactcttg atagttaccg gaacgaaata gcttatttga
1801 ataaactaca acaacacagt gataagatca tccgacttta tgattatgaa atcacggacc
1861 agtacatcta catggtaatg gagtgtggaa atattgatct taatagttgg cttaaaaaga
1921 aaaaatccat tgatccatgg gaacgcaaga gttactggaa aaatatgtta gaggcagttc
1981 acacaatcca tcaacatggc attgttcaca gtgatcttaa accagctaac tttctgatag
2041 ttgatggaat gctaaagcta attgattttg ggattgcaaa ccaaatgcaa ccagatacaa
2101 caagtgttgt taaagattct caggttggca cagttaatta tatgccacca gaagcaatca
2161 aagatatgtc ttcctccaga gagaatggga aatctaagtc aaagataagc cccaaaagtg
2221 atgtttggtc cttaggatgt attttgtact atatgactta cgggaaaaca ccatttcagc
2281 agataattaa tcagatttct aaattacatg ccataattga tcctaatcat gaaattgaat
2341 ttcccgatat tccagagaaa gatcttcaag atgtgttaaa gtgttgttta aaaagggacc
2401 caaaacagag gatatccatt cctgagctcc tggctcatcc ctatgttcaa attcaaactc
2461 atccagttaa ccaaatggcc aagggaacca ctgaagaaat gaaatatgtt ctgggccaac
2521 ttgttggtct gaattctcct aactccattt tgaaagctgc taaaacttta tatgaacact
2581 atagtggtgg tgaaagtcat aattcttcat cctccaagac ttttgaaaaa aaaaggggaa
2641 aaaaatgatt tgcagttatt cgtaatgtca aataccacct ataaaatata ttggactgtt
2701 atactcttga atccctgtgg aaatctacat ttgaagacaa catcactctg aagtgttatc
2761 agcaaaaaaa attcagtaga ttatctttaa aagaaaactg taaaaatagc aaccacttat
2821 ggtactgtat atattgtaga cttgttttct ctgttttatg ctcttgtgta atctacttga
2881 catcatttta ctcttggaat agtgggtgga tagcaagtat attctaaaaa actttgtaaa
2941 taaagttttg tggctaaaat gacactaaaa aaaaaaaaaa aaaa
//