LOCUS BC000254 3142 bp mRNA linear HUM 24-JUL-2006
DEFINITION Homo sapiens activin A receptor, type IB, mRNA (cDNA clone MGC:2177
IMAGE:3352720), complete cds.
ACCESSION BC000254
VERSION BC000254.1
KEYWORDS MGC.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3142)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 3142)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (14-NOV-2000) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: ATCC
cDNA Library Preparation: Rubin Laboratory
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
Kim MacDonald, Mike R. Mayo, Josh Moran, Diana Palmquist, JR
Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRAL Plate: 6 Row: k Column: 19
This clone was selected for full length sequencing because it
passed the following selection criteria: matched mRNA gi: 33598913.
FEATURES Location/Qualifiers
source 1..3142
/db_xref="H-InvDB:HIT000029464"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="MGC:2177 IMAGE:3352720"
/tissue_type="Eye, retinoblastoma"
/clone_lib="NIH_MGC_16"
/lab_host="DH10B-R"
/note="Vector: pOTB7"
gene 1..3142
/gene="ACVR1B"
/gene_synonym="ACTRIB"
/gene_synonym="ALK4"
/gene_synonym="SKR2"
/db_xref="GeneID:91"
/db_xref="HGNC:HGNC:172"
/db_xref="MIM:601300"
CDS 27..1544
/gene="ACVR1B"
/gene_synonym="ACTRIB"
/gene_synonym="ALK4"
/gene_synonym="SKR2"
/codon_start=1
/product="activin A receptor, type IB"
/protein_id="AAH00254.1"
/db_xref="GeneID:91"
/db_xref="HGNC:HGNC:172"
/db_xref="MIM:601300"
/translation="MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANY
TCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCN
RIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQ
RLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRF
GEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWT
QLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHR
DLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINM
KHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQ
KLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI"
BASE COUNT 674 a 783 c 917 g 768 t
ORIGIN
1 cggcggcggc ggcggcggtg gttactatgg cggagtcggc cggagcctcc tccttcttcc
61 cccttgttgt cctcctgctc gccggcagcg gcgggtccgg gccccggggg gtccaggctc
121 tgctgtgtgc gtgcaccagc tgcctccagg ccaactacac gtgtgagaca gatggggcct
181 gcatggtttc cattttcaat ctggatggga tggagcacca tgtgcgcacc tgcatcccca
241 aagtggagct ggtccctgcc gggaagccct tctactgcct gagctcggag gacctgcgca
301 acacccactg ctgctacact gactactgca acaggatcga cttgagggtg cccagtggtc
361 acctcaagga gcctgagcac ccgtccatgt ggggcccggt ggagctggta ggcatcatcg
421 ccggcccggt gttcctcctg ttcctcatca tcatcattgt tttccttgtc attaactatc
481 atcagcgtgt ctatcacaac cgccagagac tggacatgga agatccctca tgtgagatgt
541 gtctctccaa agacaagacg ctccaggatc ttgtctacga tctctccacc tcagggtctg
601 gctcagggtt acccctcttt gtccagcgca cagtggcccg aaccatcgtt ttacaagaga
661 ttattggcaa gggtcggttt ggggaagtat ggcggggccg ctggaggggt ggtgatgtgg
721 ctgtgaaaat attctcttct cgtgaagaac ggtcttggtt cagggaagca gagatatacc
781 agacggtcat gctgcgccat gaaaacatcc ttggatttat tgctgctgac aataaagata
841 atggcacctg gacacagctg tggcttgttt ctgactatca tgagcacggg tccctgtttg
901 attatctgaa ccggtacaca gtgacaattg aggggatgat taagctggcc ttgtctgctg
961 ctagtgggct ggcacacctg cacatggaga tcgtgggcac ccaagggaag cctggaattg
1021 ctcatcgaga cttaaagtca aagaacattc tggtgaagaa aaatggcatg tgtgccatag
1081 cagacctggg cctggctgtc cgtcatgatg cagtcactga caccattgac attgccccga
1141 atcagagggt ggggaccaaa cgatacatgg cccctgaagt acttgatgaa accattaata
1201 tgaaacactt tgactccttt aaatgtgctg atatttatgc cctcgggctt gtatattggg
1261 agattgctcg aagatgcaat tctggaggag tccatgaaga atatcagctg ccatattacg
1321 acttagtgcc ctctgaccct tccattgagg aaatgcgaaa ggttgtatgt gatcagaagc
1381 tgcgtcccaa catccccaac tggtggcaga gttatgaggc actgcgggtg atggggaaga
1441 tgatgcgaga gtgttggtat gccaacggcg cagcccgcct gacggccctg cgcatcaaga
1501 agaccctctc ccagctcagc gtgcaggaag acgtgaagat ctaactgctc cctctctcca
1561 cacggagctc ctggcagcga gaactacgca cagctgccgc gttgagcgta cgatggaggc
1621 ctacctctcg tttctgccca gccctctgtg gccaggagcc ctggcccgca agagggacag
1681 agcccgggag agactcgctc actcccatgt tgggtttgag acagacacct tttctattta
1741 cctcctaatg gcatggagac tctgagagcg aattgtgtgg agaactcagt gccacacctc
1801 gaactggttg tagtgggaag tcccgcgaaa cccggtgcat ctggcacgtg gccaggagcc
1861 atgacagggg cgcttgggag gggccggagg aaccgaggtg ttgccagtgc taagctgccc
1921 tgagggtttc cttcggggac cagcccacag cacaccaagg tggcccggaa gaaccagaag
1981 tgcagcccct ctcacaggca gctctgagcc gcgctttccc ctcctccctg ggatggacgc
2041 tgccgggaga ctgccagtgg agacggaatc tgccgctttg tctgtccagc cgtgtgtgca
2101 tgtgccgagg tgcgtccccc gttgtgcctg gttcgtgcca tgcccttaca cgtgcgtgtg
2161 agtgtgtgtg tgtgtctgta ggtgcgcact tacctgcttg agctttctgt gcatgtgcag
2221 gtcgggggtg tggtcgtcat gctgtccgtg cttgctggtg cctcttttca gtagtgagca
2281 gcatctagtt tccctggtgc ccttccctgg aggtctctcc ctcccccaga gcccctcatg
2341 ccacagtggt actctgtgtc tggcaggcta ctctgcccac cccagcatca gcacagctct
2401 cctcctccat ctcagactgt ggaaccaaag ctggcccagt tgtccatgac aaaagaggct
2461 tttgggccaa aatgtgaggg tggtgggtgg gatgggcagg gaaggaatcc tggtggaagt
2521 cttgggtgtt agtgtcagcc gtgggaaatg agccagccca agggcatcat cctcagcagc
2581 atcgaggaag ggccgaggaa tgtgaagcca gatctcggga ctcagattgg aatgttacat
2641 ctgtctttca tctcccagat cctggaaaca gcagtgtata tttttggtgg tggtgggttt
2701 ggggtgggga agggaagggc gggcaaggag tggggaggga gtctggggtg ggagggaggc
2761 atctgcatgg gtcttctttt actggactgt ctgatcaggg tggagggaag gtgagaggtt
2821 tgcatccact tcaggagccc tactgaaggg aacagcctga gccgaacatg ttatttaacc
2881 tgagtatagt atttaacgaa gcctagaagc acggctgtgg gtggtgattt ggtcagcata
2941 tcttaggtat ataataactt tgaagccata acttttaact ggagtggttt gatttctttt
3001 tttaatttta ttgggagggt ttggatttta acttttttta atgttgttaa atattaagtt
3061 tttgtaaaag gaaaaccatc tctgtgatta cctctcaatc tatttgtttt taaagaaatc
3121 cctaaaaaaa aaaaaaaaaa aa
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