LOCUS       AY425006                 274 bp    mRNA    linear   HUM 26-JUL-2016
DEFINITION  Homo sapiens P-glycoprotein 1 (ABCB1) mRNA, partial cds,
            alternatively spliced.
ACCESSION   AY425006
VERSION     AY425006.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 274)
  AUTHORS   Raguz,S., Tamburo De Bella,M., Tripuraneni,G., Slade,M.J.,
            Higgins,C.F., Coombes,R.C. and Yague,E.
  TITLE     Activation of the MDR1 upstream promoter in breast carcinoma as a
            surrogate for metastatic invasion
  JOURNAL   Clin. Cancer Res. 10 (8), 2776-2783 (2004)
   PUBMED   15102684
REFERENCE   2  (bases 1 to 274)
  AUTHORS   Yague,E. and Raguz,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-OCT-2003) Clinical Sciences Centre, Medical Research
            Council, DuCane Road, London W12 0NN, United Kingdom
FEATURES             Location/Qualifiers
     source          1..274
                     /db_xref="H-InvDB:HIT000254568"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.1"
     gene            1..>274
                     /gene="ABCB1"
     5'UTR           1..206
                     /gene="ABCB1"
     variation       206
                     /gene="ABCB1"
                     /replace="g"
     CDS             207..>274
                     /gene="ABCB1"
                     /note="energy-dependent efflux pump responsible for
                     decreased drug accumulation in multidrug-resistant cells;
                     derived from upstream promoter; found in drug resistant
                     cell lines, breast carcinoma patients and chronic
                     myelogenous leukemia patients; alternatively spliced"
                     /codon_start=1
                     /product="P-glycoprotein 1"
                     /protein_id="AAR91622.1"
                     /translation="MDLEGDRNGGAKKKNFFKLNNK"
BASE COUNT           88 a           57 c           62 g           67 t
ORIGIN      
        1 ctactttatt cagatattct ccagattcct aaagattaga gatcatttct cattctccta
       61 ggagtactca cttcaggaag caaccagata aaagagaggt gcaacggaag ccagaacatt
      121 cctcctggaa attcaacctg tttcgcagtt tctcgaggaa tcagcattca gtcaatccgg
      181 gccgggagca gtcatctgtg gtcggaatgg atcttgaagg ggaccgcaat ggaggagcaa
      241 agaagaagaa cttttttaaa ctgaacaata aaag
//