LOCUS AY214167 7240 bp DNA linear HUM 18-JAN-2003 DEFINITION Homo sapiens tumor necrosis factor (TNF superfamily, member 2) (TNF) gene, complete cds. ACCESSION AY214167 VERSION AY214167.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 7240) AUTHORS Rieder,M.J., Livingston,R.J., Daniels,M.R., Montoya,M.A., Chung,M.-W., Miyamoto,K.E., Nguyen,C.P., Nguyen,D.A., Poel,C.L., Robertson,P.D., Schackwitz,W.S., Sherwood,J.K., Witrak,L.A. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (08-JAN-2003) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: NIEHS-SNPs, Environmental Genome Project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). FEATURES Location/Qualifiers source 1..7240 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" variation 238 /frequency="0.01" /replace="t" variation 247 /frequency="0.01" /replace="a" variation 542 /frequency="0.02" /replace="t" variation 707 /frequency="0.24" /replace="c" variation 876 /frequency="0.15" /replace="a" variation 877 /frequency="0.99" /replace="" variation 882 /frequency="0.11" /replace="t" variation 933 /frequency="0.01" /replace="t" variation 980 /frequency="0.01" /replace="a" variation 1093 /frequency="0.01" /replace="a" variation 1167 /frequency="0.01" /replace="c" variation 1169 /frequency="0.01" /replace="a" variation 1228 /frequency="0.01" /replace="g" variation 1363 /frequency="0.02" /replace="a" variation 1431 /frequency="0.09" /replace="a" variation 1495 /frequency="0.02" /replace="a" variation 1501 /frequency="0.08" /replace="a" variation 1748 /frequency="0.01" /replace="t" gene 1750..4519 /gene="TNF" mRNA join(1750..2105,2718..2763,2951..2998,3300..4519) /gene="TNF" /product="tumor necrosis factor (TNF superfamily, member 2)" variation 1812 /gene="TNF" /frequency="0.99" /replace="" CDS join(1920..2105,2718..2763,2951..2998,3300..3721) /gene="TNF" /codon_start=1 /product="tumor necrosis factor (TNF superfamily, member 2)" /protein_id="AAO21132.1" /translation="MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGA TTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQL QWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIA VSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYL DFAESGQVYFGIIAL" variation 2006 /gene="TNF" /frequency="0.01" /replace="t" variation 2226 /gene="TNF" /frequency="0.01" /replace="t" variation 2228 /gene="TNF" /frequency="0.12" /replace="a" repeat_region 2299..2340 /gene="TNF" /rpt_family="L2" /rpt_type=dispersed variation 2369..2372 /gene="TNF" /frequency="0.99" /replace="" variation 2432 /gene="TNF" /frequency="0.01" /replace="" variation 2475..2476 /gene="TNF" /frequency="0.98" /replace="" repeat_region 2534..2583 /gene="TNF" /rpt_family="L2" /rpt_type=dispersed variation 2969 /gene="TNF" /frequency="0.01" /replace="t" variation 3049 /gene="TNF" /frequency="0.08" /replace="g" variation 3059 /gene="TNF" /frequency="0.01" /replace="a" variation 3955 /gene="TNF" /frequency="0.01" /replace="t" variation 4174 /gene="TNF" /frequency="0.01" /replace="t" variation 4902 /frequency="0.06" /replace="c" repeat_region 4903..5078 /rpt_family="MIR" /rpt_type=dispersed variation 5169 /frequency="0.01" /replace="a" repeat_region 5174..5310 /rpt_family="Alu" /rpt_type=dispersed variation 5196 /frequency="0.04" /replace="c" variation 5257 /frequency="0.04" /replace="a" variation 5387 /frequency="0.03" /replace="a" repeat_region 5473..5777 /rpt_family="Alu" /rpt_type=dispersed variation 5522 /frequency="0.04" /replace="a" variation 5827 /frequency="0.01" /replace="t" variation 5867 /frequency="0.02" /replace="a" variation 5881 /frequency="0.03" /replace="a" variation 6018 /frequency="0.01" /replace="t" variation 6673 /frequency="0.01" /replace="c" variation 6775 /frequency="0.01" /replace="c" variation 6858 /frequency="0.01" /replace="g" variation 6935 /frequency="0.01" /replace="a" BASE COUNT 1821 a 1886 c 2010 g 1523 t ORIGIN 1 ctgctgatag tcccggagct ttcaagaagg attctttcct cccaggggac cacacctccc 61 tgaatatccc tgatgtctgt ctggctgagg atttcaagcc tgcctaggaa ttcccagccc 121 aaagctgttg gtctgtccca ccagctaggt ggggcctaga tccacacaca gaggaagagc 181 aggcacatgg aggagcttgg gggatgacta gaggcaggga ggggactatt tatgaaggca 241 aaaaaattaa attatttatt tatggaggat ggagagaggg gaataataga agaacatcca 301 aggagaaaca gagacaggcc caagagatga agagtgagag ggcatgcgca caaggctgac 361 caagagagaa agaagtaggc atgagggatc acagggcccc agaaggcagg gaaaggctct 421 gaaagccagc tgccgaccag agccccacac ggaggcatct gcaccctcga tgaagcccaa 481 taaacctctt ttctctgaaa tgctgtctgc ttgtgtgtgt gtgtctggga gtgagaactt 541 cccagtctat ctaaggaatg gagggaggga cagagggctc aaagggagca agagctgtgg 601 ggagaacaaa aggataaggg ctcagagagc ttcagggata tgtgatggac tcaccaggtg 661 aggccgccag actgctgcag gggaagcaaa ggagaagctg agaagatgaa ggaaaagtca 721 gggtctggag gggcgggggt cagggagctc ctgggagata tggccacatg tagcggctct 781 gaggaatggg ttacaggaga cctctgggga gatgtgacca cagcaatggg taggagaatg 841 tccagggcta tggaagtcga gtatggggac ccccccctta acgaagacag ggccatgtag 901 agggccccag ggagtgaaag agcctccagg acctccaggt atggaataca ggggacgttt 961 aagaagatat ggccacacac tggggccctg agaagtgaga gcttcatgaa aaaaatcagg 1021 gaccccagag ttccttggaa gccaagactg aaaccagcat tatgagtctc cgggtcagaa 1081 tgaaagaaga aggcctgccc cagtggggtc tgtgaattcc cgggggtgat ttcactcccc 1141 ggggctgtcc caggcttgtc cctgctaccc ccacccagcc tttcctgagg cctcaagcct 1201 gccaccaagc ccccagctcc ttctccccgc agggacccaa acacaggcct caggactcaa 1261 cacagctttt ccctccaacc ccgttttctc tccctcaagg actcagcttt ctgaagcccc 1321 tcccagttct agttctatct ttttcctgca tcctgtctgg aagttagaag gaaacagacc 1381 acagacctgg tccccaaaag aaatggaggc aataggtttt gaggggcatg gggacggggt 1441 tcagcctcca gggtcctaca cacaaatcag tcagtggccc agaagacccc cctcggaatc 1501 ggagcaggga ggatggggag tgtgaggggt atccttgatg cttgtgtgtc cccaactttc 1561 caaatccccg cccccgcgat ggagaagaaa ccgagacaga aggtgcaggg cccactaccg 1621 cttcctccag atgagctcat gggtttctcc accaaggaag ttttccgctg gttgaatgat 1681 tctttccccg ccctcctctc gccccaggga catataaagg cagttgttgg cacacccagc 1741 cagcagacgc tccctcagca aggacagcag aggaccagct aagagggaga gaagcaacta 1801 cagacccccc cctgaaaaca accctcagac gccacatccc ctgacaagct gccaggcagg 1861 ttctcttcct ctcacatact gacccacggc tccaccctct ctcccctgga aaggacacca 1921 tgagcactga aagcatgatc cgggacgtgg agctggccga ggaggcgctc cccaagaaga 1981 caggggggcc ccagggctcc aggcggtgct tgttcctcag cctcttctcc ttcctgatcg 2041 tggcaggcgc caccacgctc ttctgcctgc tgcactttgg agtgatcggc ccccagaggg 2101 aagaggtgag tgcctggcca gccttcatcc actctcccac ccaaggggaa atggagacgc 2161 aagagaggga gagagatggg atgggtgaaa gatgtgcgct gatagggagg gatggagaga 2221 aaaaaacgtg gagaaagacg gggatgcaga aagagatgtg gcaagagatg gggaagagag 2281 agagagaaag atggagagac aggatgtctg gcacatggaa ggtgctcact aagtgtgtat 2341 ggagtgaatg aatgaatgaa tgaatgaatg aacaagcaga tatataaata agatatggag 2401 acagatgtgg ggtgtgagaa gagagatggg ggaagaaaca agtgatatga ataaagatgg 2461 tgagacagaa agagagcggg aaatatgaca gctaaggaga gagatggggg agataaggag 2521 agaagaagat agggtgtctg gcacacagaa gacactcagg gaaagagctg ttgaatgcct 2581 ggaaggtgaa tacacagatg aatggagaga gaaaaccaga cacctcaggg ctaagagcgc 2641 aggccagaca ggcagccagc tgttcctcct ttaagggtga ctccctcgat gttaaccatt 2701 ctccttctcc ccaacagttc cccagggacc tctctctaat cagccctctg gcccaggcag 2761 tcagtaagtg tctccaaacc tctttcctaa ttctgggttt gggtttgggg gtagggttag 2821 taccggtatg gaagcagtgg gggaaattta aagttttggt cttgggggag gatggatgga 2881 ggtgaaagta ggggggtatt ttctaggaag tttaagggtc tcagcttttt cttttctctc 2941 tcctcttcag gatcatcttc tcgaaccccg agtgacaagc ctgtagccca tgttgtaggt 3001 aagagctctg aggatgtgtc ttggaacttg gagggctagg atttggggat tgaagcccgg 3061 ctgatggtag gcagaacttg gagacaatgt gagaaggact cgctgagctc aagggaaggg 3121 tggaggaaca gcacaggcct tagtgggata ctcagaacgt catggccagg tgggatgtgg 3181 gatgacagac agagaggaca ggaaccggat gtggggtggg cagagctcga gggccaggat 3241 gtggagagtg aaccgacatg gccacactga ctctcctctc cctctctccc tccctccagc 3301 aaaccctcaa gctgaggggc agctccagtg gctgaaccgc cgggccaatg ccctcctggc 3361 caatggcgtg gagctgagag ataaccagct ggtggtgcca tcagagggcc tgtacctcat 3421 ctactcccag gtcctcttca agggccaagg ctgcccctcc acccatgtgc tcctcaccca 3481 caccatcagc cgcatcgccg tctcctacca gaccaaggtc aacctcctct ctgccatcaa 3541 gagcccctgc cagagggaga ccccagaggg ggctgaggcc aagccctggt atgagcccat 3601 ctatctggga ggggtcttcc agctggagaa gggtgaccga ctcagcgctg agatcaatcg 3661 gcccgactat ctcgactttg ccgagtctgg gcaggtctac tttgggatca ttgccctgtg 3721 aggaggacga acatccaacc ttcccaaacg cctcccctgc cccaatccct ttattacccc 3781 ctccttcaga caccctcaac ctcttctggc tcaaaaagag aattgggggc ttagggtcgg 3841 aacccaagct tagaacttta agcaacaaga ccaccacttc gaaacctggg attcaggaat 3901 gtgtggcctg cacagtgaag tgctggcaac cactaagaat tcaaactggg gcctccagaa 3961 ctcactgggg cctacagctt tgatccctga catctggaat ctggagacca gggagccttt 4021 ggttctggcc agaatgctgc aggacttgag aagacctcac ctagaaattg acacaagtgg 4081 accttaggcc ttcctctctc cagatgtttc cagacttcct tgagacacgg agcccagccc 4141 tccccatgga gccagctccc tctatttatg tttgcacttg tgattattta ttatttattt 4201 attatttatt tatttacaga tgaatgtatt tatttgggag accggggtat cctgggggac 4261 ccaatgtagg agctgccttg gctcagacat gttttccgtg aaaacggagc tgaacaatag 4321 gctgttccca tgtagccccc tggcctctgt gccttctttt gattatgttt tttaaaatat 4381 ttatctgatt aagttgtcta aacaatgctg atttggtgac caactgtcac tcattgctga 4441 gcctctgctc cccaggggag ttgtgtctgt aatcgcccta ctattcagtg gcgagaaata 4501 aagtttgctt agaaaagaaa catggtctcc ttcttggaat taattctgca tctgcctctt 4561 cttgtgggtg ggaagaagct ccctaagtcc tctctccaca ggctttaaga tccctcggac 4621 ccagtcccat ccttagactc ctagggccct ggagacccta cataaacaaa gcccaacaga 4681 atattcccca tcccccagga aacaagagcc tgaacctaat tacctctccc tcagggcatg 4741 ggaatttcca actctgggaa ttccaatcct tgctgggaaa atcctgcagc tcaggtgaga 4801 tttccggctg ttgcagctgg ccagcagtcc ggagagagct ggagaggagc cgcattctca 4861 ggtacctgaa tcacacagcc aagggacttc cagagattcg ggtgtctagg cttcaaatca 4921 ccctgtccta actctgcaac ctgaaccagc cacttaacct atctatccaa tggggatagg 4981 aatgtccacc acacataggg catgtgagag aaggcctgac ctccatcaga ggacctcact 5041 cagcccttgg cacagtgggc acttagtgaa ttctggcttc cttcaaccag tttccagctg 5101 ttctatcccc ttccattctc tcagtgggtg aaatcgaaga gactgaggac aataaagaac 5161 aaggaaccga actgccggac gtggtggcat gcacctgtaa tcctaccact ttgcaaggcc 5221 aaggtgagag gatcgcttga acccaggagt tccagagcaa cctgggcaac atagtgagat 5281 cctgtctcta ttttttaaaa aagaatgaaa cataggaata agatgtgggt gaaggactca 5341 catgccggct tggtcccact ggtctttgtg gtgaaggagg ggagaggtga gaggtgggta 5401 atccggaaag agaaaagcac cccctccctg gatgaaggct cttctggaga gagtcaaaga 5461 caaataaggg tggggcgcag tggctcatgc ctgttatccc aacactttgg gaggctgagg 5521 tgggaggacc acttgagccc actagttcaa gaccagcctg tgcaacatag caagaccttg 5581 tttctagaaa aaaaattaaa gattagtcag gtgtagtggt gcatgcctgt aatcctagct 5641 cctcaggagg ctgaggcagg aggatcactc aagcccagga gtttgaggtt acagtaagct 5701 atgatcatgc cactgtaccc ccgtctgggt gacagaacga gaccctgtct caaaaaaata 5761 ataattccaa aaacaaatat ggagacggaa attgagcccc cctagactgg gagcccccac 5821 tgagttcgga aattaggctt tacctccagc cctggggtgc caggcaggag aaaaccatgt 5881 ggtaggctga gggggtaggg tgacccattg gggtgaccta gatagggcct tgggtcaccc 5941 tctgcctcct ccagcctgtg gctgaaagtc agccatgaag taatggggga cactgttact 6001 catcccagaa gcacccacac ttactcactt ttgggaaggg ggacctaaag tgtgaaaaaa 6061 aggtgaggat tttccgtctc accctaaatg ggacacccta agtggggcat cggtttttcc 6121 tcctccccag aacttcctgg tgttttcagg caccacaggc tccttcctgc catccccatc 6181 tctctctaat attctcccct tctttctcct tcagcctcct cccttcagac cccatgagcc 6241 ttgaattaag ctccttggag gagaagagtt gactgtcggg taggagacag agaggccttc 6301 aggcagctct agggggagaa gtgcggggcc cctccaggct tcattcctct gtcatgatag 6361 gggcttactc tgctgctggg cctttctgag tggtgcttgc tgggctctgt aatgacccct 6421 ctcactgttg gggggtaccc aagagaaaag agtatggtgc agagtctggt tgggaccatg 6481 tggccctgaa aatcaggatg cctagagaag cttcggagtt tgagaagtcc cccttcctcc 6541 caccctccaa ctgggctaat ggtggggcct ggccattcag aggcagggag ggggtgggac 6601 aggcagacca tcatccctag gagcaaaggc catacactgt gttgtgatga attgtttcaa 6661 gcaaccagaa gagtactgag aatatttaac ccgcacccgt gcacccaccc tgaattaaga 6721 cgtgtgtcgc aactcagcat ctttatcggc agcactgaag ctttccattc tttattttca 6781 tcaggttcaa aatcaatttc caaacagtct cctacatttt tcccactgcc atggggtcct 6841 gggcgtccgg gcccccaata ttcacgcact cgcaccacgc actcatattc cctcacccca 6901 ccatcacggc cccaaagaag gtcttccctc tcgcgaagtc caccatatcg gggtgactga 6961 tgttgacgta caccctctcg cccctccgga gctgcaccag gccgccgaac cccacgctcg 7021 tgtaccagag aggcccgtac ccttgtctcc tggccgggtc cagcactgga gtcaccgtct 7081 cggcgccctc gagcagcagc tcgggagtgc ccggcccgta ggcgcccccc gcccggtaca 7141 gagagctgcg cagcgtgacc gagcggccct gggggtcccc gccgccaggg ggcgcccggc 7201 cccggtagcc gacgagacag tagaggtaat agaggccgtc //