LOCUS AH007665 5192 bp DNA linear HUM 10-JUN-2016 DEFINITION Homo sapiens tumor suppressor protein p53 (p53) gene, complete cds. ACCESSION AH007665 AF135120 AF135121 VERSION AH007665.2 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5192) AUTHORS Allalunis-Turner,M.J., Barron,G.M., Day,R.S. III, Dobler,K.D. and Mirzayans,R. TITLE Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs JOURNAL Radiat. Res. 134 (3), 349-354 (1993) PUBMED 8316628 REFERENCE 2 (bases 1 to 5192) AUTHORS Anderson,C.W. and Allalunis-Turner,M.J. TITLE Human TP53 from the malignant glioma-derived cell lines M059J and M059K has a cancer-associated mutation in exon 8 JOURNAL Radiat. Res. 154 (4), 473-476 (2000) PUBMED 11023613 REFERENCE 3 (bases 1 to 5192) AUTHORS Anderson,C.W., Kieleczawa,J. and Allalunis-Turner,M.J. TITLE Direct Submission JOURNAL Submitted (16-MAR-1999) Biology, Brookhaven National Laboratory, 50 Bell Avenue, Upton, NY 11973-5000, USA COMMENT On or before Jun 10, 2016 this sequence version replaced AF135120.1, AF135121.1, AH007665.1. FEATURES Location/Qualifiers source 1..5192 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /cell_type="M059J" /note="M059J cells produce a mutant form of p53" gene <1..>4721 /gene="p53" mRNA join(<216..289,407..428,538..816,1571..1754,1836..1948, 2517..2626,2970..3106,3199..3272,3615..3721,4640..>4721) /gene="p53" /product="tumor suppressor protein p53" CDS join(216..289,407..428,538..816,1571..1754,1836..1948, 2517..2626,2970..3106,3199..3272,3615..3721,4640..4721) /gene="p53" /note="similar to Homo sapiens p53 presented in GenBank Accession Number U94788; similar to the p53 sequence expressed by Homo sapiens M059K cells" /codon_start=1 /product="tumor suppressor protein p53" /protein_id="AAD28535.1" /translation="MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLM LSPDDIEQWFTEDPGPDEAPRMPEAAPRVAPAPAAPTPAAPAPAPSWPLSSSVPSQKT YQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAM AIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVV PYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCA CPGRDRRTEKENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRG RERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDS D" exon <216..289 /gene="p53" /number=2 exon 407..428 /gene="p53" /number=3 exon 538..816 /gene="p53" /number=4 exon 1571..1754 /gene="p53" /number=5 exon 1836..1948 /gene="p53" /number=6 exon 2517..2626 /gene="p53" /number=7 exon 2970..3106 /gene="p53" /number=8 variation 2987 /gene="p53" /replace="g" exon 3199..3272 /gene="p53" /number=9 gap 3424..3523 /estimated_length=unknown exon 3615..3721 /gene="p53" /number=10 exon 4640..>4721 /gene="p53" /number=11 BASE COUNT 1148 a 1410 c 1287 g 1247 t ORIGIN 1 gagtgcttgg gttgtggtga aacattggaa gagagaatgt gaagcagcca ttcttttcct 61 gctccacagg aagccgagct gtctcagaca ctggcatggt gttgggggag ggggttcctt 121 ctctgcaggc ccaggtgacc cagggttgga agtgtctcat gctggatccc cacttttcct 181 cttgcagcag ccagactgcc ttccgggtca ctgccatgga ggagccgcag tcagatccta 241 gcgtcgagcc ccctctgagt caggaaacat tttcagacct atggaaactg tgagtggatc 301 cattggaagg gcaggcccac caccccgacc ccaaccccag ccccctagca gagacctgtg 361 ggaagcgaaa attccatggg actgactttc tgctcttgtc tttcagactt cctgaaaaca 421 acgttctggt aaggacaagg gttgggctgg ggacctggag ggctggggac ctggagggct 481 ggggggctgg ggggctgagg acctggtcct ctgactgctc ttttcaccca tctacagtcc 541 cccttgccgt cccaagcaat ggatgatttg atgctgtccc cggacgatat tgaacaatgg 601 ttcactgaag acccaggtcc agatgaagct cccagaatgc cagaggctgc tccccgcgtg 661 gcccctgcac cagcagctcc tacaccggcg gcccctgcac cagccccctc ctggcccctg 721 tcatcttctg tcccttccca gaaaacctac cagggcagct acggtttccg tctgggcttc 781 ttgcattctg ggacagccaa gtctgtgact tgcacggtca gttgccctga ggggctggct 841 tccatgagac ttcaatgcct ggccgtatcc ccctgcattt cttttgtttg gaactttggg 901 attcctcttc accctttggc ttcctgtcag tgttttttta tagtttaccc acttaatgtg 961 tgatctctga ctcctgtccc aaagttgaat attcccccct tgaatttggg cttttatcca 1021 tcccatcaca ccctcagcat ctctcctggg gatgcagaac ttttcttttt cttcatccac 1081 gtgtattcct tggcttttga aaataagctc ctgaccaggc ttggtggctc acacctgcaa 1141 tcccagcact ctcaaagagg ccaaggcagg cagatcacct gagcccagga gttcaagacc 1201 agcctgggta acatgatgaa acctcgtctc tacaaaaaaa tacaaaaaat tagccaggca 1261 tggtggtgca cacctatagt cccagccact caggaggctg aggtgggaag atcacttgag 1321 gccaggagat ggaggctgca gtgagctgtg atcacaccac tgtgctccag cctgagtgac 1381 agagcaagac cctatctcaa aaaaaaaaaa aaagaaaagc tcctgaggtg tagacgccaa 1441 ctctctctag ctcgctagtg ggttgcagga ggtgcttaca catgtttgtt tctttgctgc 1501 cgtcttccag ttgctttatc tgttcacttg tgccctgact ttcaactctg tctccttcct 1561 cttcctacag tactcccctg ccctcaacaa gatgttttgc caactggcca agacctgccc 1621 tgtgcagctg tgggttgatt ccacaccccc gcccggcacc cgcgtccgcg ccatggccat 1681 ctacaagcag tcacagcaca tgacggaggt tgtgaggcgc tgcccccacc atgagcgctg 1741 ctcagatagc gatggtgagc agctggggct ggagagacga cagggctggt tgcccagggt 1801 ccccaggcct ctgattcctc actgattgct cttaggtctg gcccctcctc agcatcttat 1861 ccgagtggaa ggaaatttgc gtgtggagta tttggatgac agaaacactt ttcgacatag 1921 tgtggtggtg ccctatgagc cgcctgaggt ctggtttgca actggggtct ctgggaggag 1981 gggttaaggg tggttgtcag tggccctccg ggtgagcagt aggggggctt tctcctgctg 2041 cttatttgac ctccctataa ccccatgaga tgtgcaaagt aaatgggttt aactattgca 2101 cagttgaaaa aactgaagct tacagaggct aagggcctcc cctgcttggc tgggcgcagt 2161 ggctcatgcc tgtaatccca gcactttggg aggccaaggc aggcggatca cgaggttggg 2221 agatcgagac catcctggct aacggtgaaa ccccgtctct actgaaaaat acaaaaaaaa 2281 attagccggg cgtggtgctg ggcacctgta gtcccagcta ctcgggaggc tgaggaagga 2341 gaatggcgtg aacctgggcg gtggagcttg cagtgagctg agatcacgcc actgcactcc 2401 agcctgggcg acagagcgag attccatctc aaaaaaaaaa aaaaaaggcc tcccctgctt 2461 gccacaggtc tccccaaggc gcactggcct catcttgggc ctgtgttatc tcctaggttg 2521 gctctgactg taccaccatc cactacaact acatgtgtaa cagttcctgc atgggcggca 2581 tgaaccggag gcccatcctc accatcatca cactggaaga ctccaggtca ggagccactt 2641 gccaccctgc acactggcct gctgtgcccc agcctctgct tgcctctgac ccctgggccc 2701 acctcttacc gatttcttcc atactactac ccatccacct ctcatcacat ccccggcggg 2761 gaatctcctt actgctccca ctcagttttc ttttctctgg ctttgggacc tcttaacctg 2821 tggcttctcc tccacctacc tggagctgga gcttaggctc cagaaaggac aagggtggtt 2881 gggagtagat ggagcctggt tttttaaatg ggacaggtag gacctgattt ccttactgcc 2941 tcttgcttct cttttcctat cctgagtagt ggtaatctac tgggacggaa cagctttgag 3001 gtgcgtgttt gtgcctgtcc tgggagagac cggcgcacag agaaagagaa tctccgcaag 3061 aaaggggagc ctcaccacga gctgccccca gggagcacta agcgaggtaa gcaagcagga 3121 caagaagcgg tggaggagac caagggtgca gttatgcctc agattcactt ttatcacctt 3181 tccttgcctc tttcctagca ctgcccaaca acaccagctc ctctccccag ccaaagaaga 3241 aaccactgga tggagaatat ttcacccttc aggtactaag tcttgggacc tcttatcaag 3301 tggaaagttt ccagtctaac actcaaaatg ccgttttctt cttgactgtt ttacctgcaa 3361 ttggggcatt tgccatcagg gggcagtgat gcctcaaaga caatggctcc tggttgtagc 3421 taannnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnccgtcat aaagtcaaac 3541 aattgtaact tgaaccatct tttaactcag gtactgtgta tatacttact tctccccctc 3601 ctctgttgct gcagatccgt gggcgtgagc gcttcgagat gttccgagag ctgaatgagg 3661 ccttggaact caaggatgcc caggctggga aggagccagg ggggagcagg gctcactcca 3721 ggtgagtgac ctcagcccct tcctggccct tctcccctgc cttcctaggt tggaaagcca 3781 taggattcca ttctcatcct gccttcatgg tcaaaggcag ctgaccccat ctcattgggt 3841 cccagccctg cacagacatt tttttagtct tcctccggtt gaatcctata accacattct 3901 tgcctcagtg tatccacaga acatccaaac ccagggacga gtgtggatac ttctttgcca 3961 ttctccgcaa ctcccagccc agagctggag ggtctcaagg aggggcctaa taattgtgta 4021 atactgaata cagccagagt ttcaggtcat atactcagcc ctgccatgca ccggcaggtc 4081 ctaggtgacc cccgtcaaac tcagtttcct tatatataaa atggggtaag ggggccgggc 4141 gcagtggctc acgaatccca cactctggga ggccaaggcg agtggatcac ctgaggtcgg 4201 gagtttgagc ccagcctgac caacatggag aaaccccatc tctactaaaa atacaaaagt 4261 agccgggcgt ggtgatgcat gcctgtaatc ccagctacct actcgggagg ctgaggcagg 4321 agaatcgctt gaacccggga ggcagaggtt gcggtgagct gagatctcac cattacactc 4381 cagcctgggc aacaagagtg aaactccgtc tcaaaaaaga taaataaagt aaaatggggt 4441 aagggaagat tacgagacta atacacacta atactctgag gtgctcagta aacatatttg 4501 catggggtgt ggccaccatc ttgatttgaa ttcccgttgt cccagcctta ggcccttcaa 4561 agcattggtc agggaaaagg ggcacagacc ctctcactca tgtgatgtca tctctcctcc 4621 ctgcttctgt ctcctacagc cacctgaagt ccaaaaaggg tcagtctacc tcccgccata 4681 aaaaactcat gttcaagaca gaagggcctg actcagactg acattctcca cttcttgttc 4741 cccactgaca gcctcccacc cccatctctc cctcccctgc cattttgggt tttgggtctt 4801 tgaacccttg cttgcaatag gtgtgcgtca gaagcaccca ggacttccat ttgctttgtc 4861 ccggggctcc actgaacaag ttggcctgca ctggtgtttt gttgtgggga ggaggatggg 4921 gagtaggaca taccagctta gattttaagg tttttactgt gagggatgtt tgggagatgt 4981 aagaaatgtt cttgcagtta agggttagtt tacaatcagc cacattctag gtaggggccc 5041 acttcaccgt actaaccagg gaagctgtcc ctcactgttg aattttctct aacttcaagg 5101 cccatatctg tgaaatgctg gcatttgcac ctacctcaca gagtgcattg tgagggttaa 5161 tgaaataatg tacatctggc cttgaaacca cc //