LOCUS       AH007665                5192 bp    DNA     linear   HUM 10-JUN-2016
DEFINITION  Homo sapiens tumor suppressor protein p53 (p53) gene, complete cds.
ACCESSION   AH007665 AF135120 AF135121
VERSION     AH007665.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5192)
  AUTHORS   Allalunis-Turner,M.J., Barron,G.M., Day,R.S. III, Dobler,K.D. and
            Mirzayans,R.
  TITLE     Isolation of two cell lines from a human malignant glioma specimen
            differing in sensitivity to radiation and chemotherapeutic drugs
  JOURNAL   Radiat. Res. 134 (3), 349-354 (1993)
   PUBMED   8316628
REFERENCE   2  (bases 1 to 5192)
  AUTHORS   Anderson,C.W. and Allalunis-Turner,M.J.
  TITLE     Human TP53 from the malignant glioma-derived cell lines M059J and
            M059K has a cancer-associated mutation in exon 8
  JOURNAL   Radiat. Res. 154 (4), 473-476 (2000)
   PUBMED   11023613
REFERENCE   3  (bases 1 to 5192)
  AUTHORS   Anderson,C.W., Kieleczawa,J. and Allalunis-Turner,M.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAR-1999) Biology, Brookhaven National Laboratory, 50
            Bell Avenue, Upton, NY 11973-5000, USA
COMMENT     On or before Jun 10, 2016 this sequence version replaced
            AF135120.1, AF135121.1, AH007665.1.
FEATURES             Location/Qualifiers
     source          1..5192
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /cell_type="M059J"
                     /note="M059J cells produce a mutant form of p53"
     gene            <1..>4721
                     /gene="p53"
     mRNA            join(<216..289,407..428,538..816,1571..1754,1836..1948,
                     2517..2626,2970..3106,3199..3272,3615..3721,4640..>4721)
                     /gene="p53"
                     /product="tumor suppressor protein p53"
     CDS             join(216..289,407..428,538..816,1571..1754,1836..1948,
                     2517..2626,2970..3106,3199..3272,3615..3721,4640..4721)
                     /gene="p53"
                     /note="similar to Homo sapiens p53 presented in GenBank
                     Accession Number U94788; similar to the p53 sequence
                     expressed by Homo sapiens M059K cells"
                     /codon_start=1
                     /product="tumor suppressor protein p53"
                     /protein_id="AAD28535.1"
                     /translation="MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLM
                     LSPDDIEQWFTEDPGPDEAPRMPEAAPRVAPAPAAPTPAAPAPAPSWPLSSSVPSQKT
                     YQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAM
                     AIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVV
                     PYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCA
                     CPGRDRRTEKENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRG
                     RERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDS
                     D"
     exon            <216..289
                     /gene="p53"
                     /number=2
     exon            407..428
                     /gene="p53"
                     /number=3
     exon            538..816
                     /gene="p53"
                     /number=4
     exon            1571..1754
                     /gene="p53"
                     /number=5
     exon            1836..1948
                     /gene="p53"
                     /number=6
     exon            2517..2626
                     /gene="p53"
                     /number=7
     exon            2970..3106
                     /gene="p53"
                     /number=8
     variation       2987
                     /gene="p53"
                     /replace="g"
     exon            3199..3272
                     /gene="p53"
                     /number=9
     gap             3424..3523
                     /estimated_length=unknown
     exon            3615..3721
                     /gene="p53"
                     /number=10
     exon            4640..>4721
                     /gene="p53"
                     /number=11
BASE COUNT         1148 a         1410 c         1287 g         1247 t
ORIGIN      
        1 gagtgcttgg gttgtggtga aacattggaa gagagaatgt gaagcagcca ttcttttcct
       61 gctccacagg aagccgagct gtctcagaca ctggcatggt gttgggggag ggggttcctt
      121 ctctgcaggc ccaggtgacc cagggttgga agtgtctcat gctggatccc cacttttcct
      181 cttgcagcag ccagactgcc ttccgggtca ctgccatgga ggagccgcag tcagatccta
      241 gcgtcgagcc ccctctgagt caggaaacat tttcagacct atggaaactg tgagtggatc
      301 cattggaagg gcaggcccac caccccgacc ccaaccccag ccccctagca gagacctgtg
      361 ggaagcgaaa attccatggg actgactttc tgctcttgtc tttcagactt cctgaaaaca
      421 acgttctggt aaggacaagg gttgggctgg ggacctggag ggctggggac ctggagggct
      481 ggggggctgg ggggctgagg acctggtcct ctgactgctc ttttcaccca tctacagtcc
      541 cccttgccgt cccaagcaat ggatgatttg atgctgtccc cggacgatat tgaacaatgg
      601 ttcactgaag acccaggtcc agatgaagct cccagaatgc cagaggctgc tccccgcgtg
      661 gcccctgcac cagcagctcc tacaccggcg gcccctgcac cagccccctc ctggcccctg
      721 tcatcttctg tcccttccca gaaaacctac cagggcagct acggtttccg tctgggcttc
      781 ttgcattctg ggacagccaa gtctgtgact tgcacggtca gttgccctga ggggctggct
      841 tccatgagac ttcaatgcct ggccgtatcc ccctgcattt cttttgtttg gaactttggg
      901 attcctcttc accctttggc ttcctgtcag tgttttttta tagtttaccc acttaatgtg
      961 tgatctctga ctcctgtccc aaagttgaat attcccccct tgaatttggg cttttatcca
     1021 tcccatcaca ccctcagcat ctctcctggg gatgcagaac ttttcttttt cttcatccac
     1081 gtgtattcct tggcttttga aaataagctc ctgaccaggc ttggtggctc acacctgcaa
     1141 tcccagcact ctcaaagagg ccaaggcagg cagatcacct gagcccagga gttcaagacc
     1201 agcctgggta acatgatgaa acctcgtctc tacaaaaaaa tacaaaaaat tagccaggca
     1261 tggtggtgca cacctatagt cccagccact caggaggctg aggtgggaag atcacttgag
     1321 gccaggagat ggaggctgca gtgagctgtg atcacaccac tgtgctccag cctgagtgac
     1381 agagcaagac cctatctcaa aaaaaaaaaa aaagaaaagc tcctgaggtg tagacgccaa
     1441 ctctctctag ctcgctagtg ggttgcagga ggtgcttaca catgtttgtt tctttgctgc
     1501 cgtcttccag ttgctttatc tgttcacttg tgccctgact ttcaactctg tctccttcct
     1561 cttcctacag tactcccctg ccctcaacaa gatgttttgc caactggcca agacctgccc
     1621 tgtgcagctg tgggttgatt ccacaccccc gcccggcacc cgcgtccgcg ccatggccat
     1681 ctacaagcag tcacagcaca tgacggaggt tgtgaggcgc tgcccccacc atgagcgctg
     1741 ctcagatagc gatggtgagc agctggggct ggagagacga cagggctggt tgcccagggt
     1801 ccccaggcct ctgattcctc actgattgct cttaggtctg gcccctcctc agcatcttat
     1861 ccgagtggaa ggaaatttgc gtgtggagta tttggatgac agaaacactt ttcgacatag
     1921 tgtggtggtg ccctatgagc cgcctgaggt ctggtttgca actggggtct ctgggaggag
     1981 gggttaaggg tggttgtcag tggccctccg ggtgagcagt aggggggctt tctcctgctg
     2041 cttatttgac ctccctataa ccccatgaga tgtgcaaagt aaatgggttt aactattgca
     2101 cagttgaaaa aactgaagct tacagaggct aagggcctcc cctgcttggc tgggcgcagt
     2161 ggctcatgcc tgtaatccca gcactttggg aggccaaggc aggcggatca cgaggttggg
     2221 agatcgagac catcctggct aacggtgaaa ccccgtctct actgaaaaat acaaaaaaaa
     2281 attagccggg cgtggtgctg ggcacctgta gtcccagcta ctcgggaggc tgaggaagga
     2341 gaatggcgtg aacctgggcg gtggagcttg cagtgagctg agatcacgcc actgcactcc
     2401 agcctgggcg acagagcgag attccatctc aaaaaaaaaa aaaaaaggcc tcccctgctt
     2461 gccacaggtc tccccaaggc gcactggcct catcttgggc ctgtgttatc tcctaggttg
     2521 gctctgactg taccaccatc cactacaact acatgtgtaa cagttcctgc atgggcggca
     2581 tgaaccggag gcccatcctc accatcatca cactggaaga ctccaggtca ggagccactt
     2641 gccaccctgc acactggcct gctgtgcccc agcctctgct tgcctctgac ccctgggccc
     2701 acctcttacc gatttcttcc atactactac ccatccacct ctcatcacat ccccggcggg
     2761 gaatctcctt actgctccca ctcagttttc ttttctctgg ctttgggacc tcttaacctg
     2821 tggcttctcc tccacctacc tggagctgga gcttaggctc cagaaaggac aagggtggtt
     2881 gggagtagat ggagcctggt tttttaaatg ggacaggtag gacctgattt ccttactgcc
     2941 tcttgcttct cttttcctat cctgagtagt ggtaatctac tgggacggaa cagctttgag
     3001 gtgcgtgttt gtgcctgtcc tgggagagac cggcgcacag agaaagagaa tctccgcaag
     3061 aaaggggagc ctcaccacga gctgccccca gggagcacta agcgaggtaa gcaagcagga
     3121 caagaagcgg tggaggagac caagggtgca gttatgcctc agattcactt ttatcacctt
     3181 tccttgcctc tttcctagca ctgcccaaca acaccagctc ctctccccag ccaaagaaga
     3241 aaccactgga tggagaatat ttcacccttc aggtactaag tcttgggacc tcttatcaag
     3301 tggaaagttt ccagtctaac actcaaaatg ccgttttctt cttgactgtt ttacctgcaa
     3361 ttggggcatt tgccatcagg gggcagtgat gcctcaaaga caatggctcc tggttgtagc
     3421 taannnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnccgtcat aaagtcaaac
     3541 aattgtaact tgaaccatct tttaactcag gtactgtgta tatacttact tctccccctc
     3601 ctctgttgct gcagatccgt gggcgtgagc gcttcgagat gttccgagag ctgaatgagg
     3661 ccttggaact caaggatgcc caggctggga aggagccagg ggggagcagg gctcactcca
     3721 ggtgagtgac ctcagcccct tcctggccct tctcccctgc cttcctaggt tggaaagcca
     3781 taggattcca ttctcatcct gccttcatgg tcaaaggcag ctgaccccat ctcattgggt
     3841 cccagccctg cacagacatt tttttagtct tcctccggtt gaatcctata accacattct
     3901 tgcctcagtg tatccacaga acatccaaac ccagggacga gtgtggatac ttctttgcca
     3961 ttctccgcaa ctcccagccc agagctggag ggtctcaagg aggggcctaa taattgtgta
     4021 atactgaata cagccagagt ttcaggtcat atactcagcc ctgccatgca ccggcaggtc
     4081 ctaggtgacc cccgtcaaac tcagtttcct tatatataaa atggggtaag ggggccgggc
     4141 gcagtggctc acgaatccca cactctggga ggccaaggcg agtggatcac ctgaggtcgg
     4201 gagtttgagc ccagcctgac caacatggag aaaccccatc tctactaaaa atacaaaagt
     4261 agccgggcgt ggtgatgcat gcctgtaatc ccagctacct actcgggagg ctgaggcagg
     4321 agaatcgctt gaacccggga ggcagaggtt gcggtgagct gagatctcac cattacactc
     4381 cagcctgggc aacaagagtg aaactccgtc tcaaaaaaga taaataaagt aaaatggggt
     4441 aagggaagat tacgagacta atacacacta atactctgag gtgctcagta aacatatttg
     4501 catggggtgt ggccaccatc ttgatttgaa ttcccgttgt cccagcctta ggcccttcaa
     4561 agcattggtc agggaaaagg ggcacagacc ctctcactca tgtgatgtca tctctcctcc
     4621 ctgcttctgt ctcctacagc cacctgaagt ccaaaaaggg tcagtctacc tcccgccata
     4681 aaaaactcat gttcaagaca gaagggcctg actcagactg acattctcca cttcttgttc
     4741 cccactgaca gcctcccacc cccatctctc cctcccctgc cattttgggt tttgggtctt
     4801 tgaacccttg cttgcaatag gtgtgcgtca gaagcaccca ggacttccat ttgctttgtc
     4861 ccggggctcc actgaacaag ttggcctgca ctggtgtttt gttgtgggga ggaggatggg
     4921 gagtaggaca taccagctta gattttaagg tttttactgt gagggatgtt tgggagatgt
     4981 aagaaatgtt cttgcagtta agggttagtt tacaatcagc cacattctag gtaggggccc
     5041 acttcaccgt actaaccagg gaagctgtcc ctcactgttg aattttctct aacttcaagg
     5101 cccatatctg tgaaatgctg gcatttgcac ctacctcaca gagtgcattg tgagggttaa
     5161 tgaaataatg tacatctggc cttgaaacca cc
//