LOCUS AF417578 3201 bp mRNA linear HUM 05-MAR-2003 DEFINITION Homo sapiens transmembrane channel-like protein 1 (TMC1) mRNA, complete cds. ACCESSION AF417578 VERSION AF417578.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3201) AUTHORS Kurima,K., Peters,L.M., Yang,Y., Riazuddin,S., Ahmed,Z.M., Naz,S., Arnaud,D., Drury,S., Mo,J., Makishima,T., Ghosh,M., Menon,P.S.N., Deshmukh,D., Oddoux,C., Ostrer,H., Khan,S., Raizuddin,S., Deininger,P.L., Hampton,L.L., Sullivan,S.L., Battey,J.F., Keats,B.J.B., Wilcox,E.R., Friedman,T.B. and Griffith,A.J. TITLE Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function JOURNAL Nat. Genet. 30 (3), 277-284 (2002) PUBMED 11850618 REFERENCE 2 (bases 1 to 3201) AUTHORS Kurima,K., Griffith,A.J. and Friedman,T.B. TITLE Direct Submission JOURNAL Submitted (10-SEP-2001) NIDCD, NIH, 5 Research Court, #2A02, Rockville, MD 20850, USA FEATURES Location/Qualifiers source 1..3201 /db_xref="H-InvDB:HIT000079329" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="9" /map="9q13" gene 1..3201 /gene="TMC1" CDS 541..2823 /gene="TMC1" /codon_start=1 /product="transmembrane channel-like protein 1" /protein_id="AAL86399.1" /translation="MSPKKVQIKVEEKEDETEESSSEEEEEVEDKLPRRESLRPKRKR TRDVINEDDPEPEPEDEETRKAREKERRRRLKRGAEKEEIDEEELERLKAELDEKRQI IATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKRWFAFKMMMAKKWAKFLRDF ENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWG LPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWMNFRLPLS YFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNK FNSITMNFKEAITEEKAAQVEENVHLIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQE FAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALL LGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNASFSENSTGPPFFVHPA DVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYP SYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEA RVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLE HDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDLKKKMKMQALE NKMRNKKMAAARAAAAAGRQ" BASE COUNT 921 a 663 c 764 g 853 t ORIGIN 1 cagaaactat gagggcagaa cccagcaatc tgtgctttct ttcacaagcc ctccaggagt 61 tgctgaaatt taggaatcat tgccccaaaa agtggccctc ataatgatgc cagatgggat 121 cttactctgt tgcccaggct ggagtgcagt ggtgcgatct cggctctctg caacctccgc 181 ctcccaggtt caagtgattc tcctgcctcg gcctcctgag tagctgggat ttcaggccat 241 gaaagatcac tgttttagtc tgcgtggtgc agtggaacag atagacctcg gtttgaatct 301 cagctctact gtttactaga cgtgaaatgg ggaaatctaa aatgagatgc cagaagcctc 361 aaaaatggaa aaccccctgt gcttcacatc tgaaaatctc tgctgggggc agcaactttg 421 agcctgtggg gaaggaactg tccacgtgga gtggtctggt gaatgcttaa ggagctgcag 481 aagggaagtc cctctccaaa ctagccagcc actgagacct tctgacagga cacccccagg 541 atgtcaccca aaaaagtaca aatcaaagtg gaggaaaaag aagacgagac tgaggaaagc 601 tcaagtgaag aggaagagga ggtggaagat aagctacctc gaagagagag cttgagacca 661 aagaggaaac ggaccagaga tgttatcaat gaggatgacc cagaacctga accagaggat 721 gaagaaacaa ggaaggcaag agaaaaagag aggaggagga ggctaaagag aggagcagaa 781 aaagaagaaa ttgatgaaga ggaattggaa agattgaagg cagagttaga tgagaaaaga 841 caaataattg ctactgtcaa atgcaaacca tggaagatgg agaagaaaat tgaagttctc 901 aaggaggcaa aaaaatttgt gagtgaaaat gaaggggctc ttgggaaagg aaaaggaaaa 961 cggtggtttg catttaagat gatgatggcc aagaaatggg caaaattcct ccgtgatttt 1021 gagaacttca aagctgcgtg tgtcccatgg gaaaataaaa tcaaggctat tgaaagtcag 1081 tttggctcct cagtggcctc atacttcctc ttcttgagat ggatgtatgg agtcaatatg 1141 gttctcttta tcctgacatt tagcctcatc atgttgccag agtacctctg gggtttgcca 1201 tatggcagtt tacctaggaa aaccgttccc agagccgaag aggcatcggc agcaaacttt 1261 ggtgtgttgt acgacttcaa tggtttggca caatattccg ttctctttta tggctattat 1321 gacaataaac gaacaattgg atggatgaat ttcaggttgc cgctctccta ttttctagtg 1381 gggattatgt gcattggata cagctttctg gttgtcctca aagcaatgac caaaaacatt 1441 ggtgatgatg gaggtggaga tgacaacact ttcaatttca gctggaaggt ctttaccagc 1501 tgggactacc tgatcggcaa tcctgaaaca gcagacaaca aatttaattc tatcacaatg 1561 aactttaagg aagctatcac agaagaaaaa gcagcccaag tagaagaaaa cgtccacttg 1621 atcagattcc tgaggtttct ggctaacttc ttcgtgtttc taacacttgg agggagtgga 1681 tacctcatct tttgggctgt gaagcgatcc caggaatttg cacagcaaga tcctgacacc 1741 cttgggtggt gggaaaaaaa tgaaatgaac atggttatgt ccctcctagg gatgttctgt 1801 ccaacattgt ttgacttatt tgctgaatta gaagactacc atcctctcat cgctttgaaa 1861 tggctactgg gacgcatttt tgctcttctt ttaggcaatt tatacgtatt tattcttgca 1921 ttaatggatg agattaacaa caagattgaa gaggagaagc tagtaaaggc caatattacc 1981 ctttgggaag ccaatatgat caaggcctac aatgcatcat tctctgaaaa tagcactgga 2041 ccaccctttt ttgttcaccc tgcagatgta cctcgaggac cttgctggga aacaatggtg 2101 ggacaggagt ttgtgaggct gacagtctct gatgttctga ccacctacgt cacaatcctc 2161 attggggact ttctaagggc atgttttgtg aggttttgca attattgctg gtgctgggac 2221 ttggagtatg gatatccttc atacaccgaa ttcgacatca gtggcaacgt cctcgctctg 2281 atcttcaacc aaggcatgat ctggatgggc tccttctttg ctcccagcct cccaggcatc 2341 aatatccttc gactccatac atccatgtac ttccagtgct gggccgttat gtgctgcaat 2401 gttcctgagg ccagggtctt caaagcttcc agatcaaata acttctacct gggcatgcta 2461 ctgctcatcc tcttcctgtc cacaatgcct gtcttgtaca tgatcgtgtc cctcccacca 2521 tcttttgatt gtggtccatt cagtggcaaa aatagaatgt ttgaagtcat tggagagacc 2581 ctggagcacg atttcccaag ctggatggcg aagatcttga gacagctttc aaaccctggg 2641 ctggtcattg ctgtcatttt ggtgatggtt ttggccatct attatctcaa tgctactgcc 2701 aagggccaga aggcagcgaa tctggatctc aaaaagaaga tgaaaatgca agctttggag 2761 aacaaaatgc gaaacaagaa aatggcagct gcacgagcag ctgcagctgc tggtcgccag 2821 taataagtat cctgagagcc cagaaaaggt acactttgcc ttgctgttta aaagtaatgc 2881 aatatgtgaa cgcccagaga acaagcactg tggaactgct attttcctgt tctacccttg 2941 atggattttc aaggtcatgc tggccaatta aggcatcatc agtcctacct gagcaacaag 3001 aatctaaact ttattccaag tcagaaactg tttctgcaga gccactctct cccctgctcc 3061 atttcgtgac tttttttttt tttttaacaa attgagttta gaagtgagtg taatccagca 3121 atacagttta ctggtttagt tggtgggtta attaaaaaaa atttgctcat atgaactttc 3181 attttatatg tttcttttgc c //