LOCUS       AF417578                3201 bp    mRNA    linear   HUM 05-MAR-2003
DEFINITION  Homo sapiens transmembrane channel-like protein 1 (TMC1) mRNA,
            complete cds.
ACCESSION   AF417578
VERSION     AF417578.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3201)
  AUTHORS   Kurima,K., Peters,L.M., Yang,Y., Riazuddin,S., Ahmed,Z.M., Naz,S.,
            Arnaud,D., Drury,S., Mo,J., Makishima,T., Ghosh,M., Menon,P.S.N.,
            Deshmukh,D., Oddoux,C., Ostrer,H., Khan,S., Raizuddin,S.,
            Deininger,P.L., Hampton,L.L., Sullivan,S.L., Battey,J.F.,
            Keats,B.J.B., Wilcox,E.R., Friedman,T.B. and Griffith,A.J.
  TITLE     Dominant and recessive deafness caused by mutations of a novel
            gene, TMC1, required for cochlear hair-cell function
  JOURNAL   Nat. Genet. 30 (3), 277-284 (2002)
   PUBMED   11850618
REFERENCE   2  (bases 1 to 3201)
  AUTHORS   Kurima,K., Griffith,A.J. and Friedman,T.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2001) NIDCD, NIH, 5 Research Court, #2A02,
            Rockville, MD 20850, USA
FEATURES             Location/Qualifiers
     source          1..3201
                     /db_xref="H-InvDB:HIT000079329"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q13"
     gene            1..3201
                     /gene="TMC1"
     CDS             541..2823
                     /gene="TMC1"
                     /codon_start=1
                     /product="transmembrane channel-like protein 1"
                     /protein_id="AAL86399.1"
                     /translation="MSPKKVQIKVEEKEDETEESSSEEEEEVEDKLPRRESLRPKRKR
                     TRDVINEDDPEPEPEDEETRKAREKERRRRLKRGAEKEEIDEEELERLKAELDEKRQI
                     IATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKRWFAFKMMMAKKWAKFLRDF
                     ENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWG
                     LPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWMNFRLPLS
                     YFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNK
                     FNSITMNFKEAITEEKAAQVEENVHLIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQE
                     FAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALL
                     LGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNASFSENSTGPPFFVHPA
                     DVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYP
                     SYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEA
                     RVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLE
                     HDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDLKKKMKMQALE
                     NKMRNKKMAAARAAAAAGRQ"
BASE COUNT          921 a          663 c          764 g          853 t
ORIGIN      
        1 cagaaactat gagggcagaa cccagcaatc tgtgctttct ttcacaagcc ctccaggagt
       61 tgctgaaatt taggaatcat tgccccaaaa agtggccctc ataatgatgc cagatgggat
      121 cttactctgt tgcccaggct ggagtgcagt ggtgcgatct cggctctctg caacctccgc
      181 ctcccaggtt caagtgattc tcctgcctcg gcctcctgag tagctgggat ttcaggccat
      241 gaaagatcac tgttttagtc tgcgtggtgc agtggaacag atagacctcg gtttgaatct
      301 cagctctact gtttactaga cgtgaaatgg ggaaatctaa aatgagatgc cagaagcctc
      361 aaaaatggaa aaccccctgt gcttcacatc tgaaaatctc tgctgggggc agcaactttg
      421 agcctgtggg gaaggaactg tccacgtgga gtggtctggt gaatgcttaa ggagctgcag
      481 aagggaagtc cctctccaaa ctagccagcc actgagacct tctgacagga cacccccagg
      541 atgtcaccca aaaaagtaca aatcaaagtg gaggaaaaag aagacgagac tgaggaaagc
      601 tcaagtgaag aggaagagga ggtggaagat aagctacctc gaagagagag cttgagacca
      661 aagaggaaac ggaccagaga tgttatcaat gaggatgacc cagaacctga accagaggat
      721 gaagaaacaa ggaaggcaag agaaaaagag aggaggagga ggctaaagag aggagcagaa
      781 aaagaagaaa ttgatgaaga ggaattggaa agattgaagg cagagttaga tgagaaaaga
      841 caaataattg ctactgtcaa atgcaaacca tggaagatgg agaagaaaat tgaagttctc
      901 aaggaggcaa aaaaatttgt gagtgaaaat gaaggggctc ttgggaaagg aaaaggaaaa
      961 cggtggtttg catttaagat gatgatggcc aagaaatggg caaaattcct ccgtgatttt
     1021 gagaacttca aagctgcgtg tgtcccatgg gaaaataaaa tcaaggctat tgaaagtcag
     1081 tttggctcct cagtggcctc atacttcctc ttcttgagat ggatgtatgg agtcaatatg
     1141 gttctcttta tcctgacatt tagcctcatc atgttgccag agtacctctg gggtttgcca
     1201 tatggcagtt tacctaggaa aaccgttccc agagccgaag aggcatcggc agcaaacttt
     1261 ggtgtgttgt acgacttcaa tggtttggca caatattccg ttctctttta tggctattat
     1321 gacaataaac gaacaattgg atggatgaat ttcaggttgc cgctctccta ttttctagtg
     1381 gggattatgt gcattggata cagctttctg gttgtcctca aagcaatgac caaaaacatt
     1441 ggtgatgatg gaggtggaga tgacaacact ttcaatttca gctggaaggt ctttaccagc
     1501 tgggactacc tgatcggcaa tcctgaaaca gcagacaaca aatttaattc tatcacaatg
     1561 aactttaagg aagctatcac agaagaaaaa gcagcccaag tagaagaaaa cgtccacttg
     1621 atcagattcc tgaggtttct ggctaacttc ttcgtgtttc taacacttgg agggagtgga
     1681 tacctcatct tttgggctgt gaagcgatcc caggaatttg cacagcaaga tcctgacacc
     1741 cttgggtggt gggaaaaaaa tgaaatgaac atggttatgt ccctcctagg gatgttctgt
     1801 ccaacattgt ttgacttatt tgctgaatta gaagactacc atcctctcat cgctttgaaa
     1861 tggctactgg gacgcatttt tgctcttctt ttaggcaatt tatacgtatt tattcttgca
     1921 ttaatggatg agattaacaa caagattgaa gaggagaagc tagtaaaggc caatattacc
     1981 ctttgggaag ccaatatgat caaggcctac aatgcatcat tctctgaaaa tagcactgga
     2041 ccaccctttt ttgttcaccc tgcagatgta cctcgaggac cttgctggga aacaatggtg
     2101 ggacaggagt ttgtgaggct gacagtctct gatgttctga ccacctacgt cacaatcctc
     2161 attggggact ttctaagggc atgttttgtg aggttttgca attattgctg gtgctgggac
     2221 ttggagtatg gatatccttc atacaccgaa ttcgacatca gtggcaacgt cctcgctctg
     2281 atcttcaacc aaggcatgat ctggatgggc tccttctttg ctcccagcct cccaggcatc
     2341 aatatccttc gactccatac atccatgtac ttccagtgct gggccgttat gtgctgcaat
     2401 gttcctgagg ccagggtctt caaagcttcc agatcaaata acttctacct gggcatgcta
     2461 ctgctcatcc tcttcctgtc cacaatgcct gtcttgtaca tgatcgtgtc cctcccacca
     2521 tcttttgatt gtggtccatt cagtggcaaa aatagaatgt ttgaagtcat tggagagacc
     2581 ctggagcacg atttcccaag ctggatggcg aagatcttga gacagctttc aaaccctggg
     2641 ctggtcattg ctgtcatttt ggtgatggtt ttggccatct attatctcaa tgctactgcc
     2701 aagggccaga aggcagcgaa tctggatctc aaaaagaaga tgaaaatgca agctttggag
     2761 aacaaaatgc gaaacaagaa aatggcagct gcacgagcag ctgcagctgc tggtcgccag
     2821 taataagtat cctgagagcc cagaaaaggt acactttgcc ttgctgttta aaagtaatgc
     2881 aatatgtgaa cgcccagaga acaagcactg tggaactgct attttcctgt tctacccttg
     2941 atggattttc aaggtcatgc tggccaatta aggcatcatc agtcctacct gagcaacaag
     3001 aatctaaact ttattccaag tcagaaactg tttctgcaga gccactctct cccctgctcc
     3061 atttcgtgac tttttttttt tttttaacaa attgagttta gaagtgagtg taatccagca
     3121 atacagttta ctggtttagt tggtgggtta attaaaaaaa atttgctcat atgaactttc
     3181 attttatatg tttcttttgc c
//