LOCUS AF322642 3931 bp mRNA linear HUM 09-APR-2001
DEFINITION Homo sapiens caspase recruitment domain protein 14 mRNA, complete
cds.
ACCESSION AF322642
VERSION AF322642.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3931)
AUTHORS Bertin,J., Wang,L., Guo,Y., Jacobson,M.D., Poyet,J.L.,
Srinivasula,S.M., Merriam,S., DiStefano,P.S. and Alnemri,E.S.
TITLE CARD11 and CARD14 are novel caspase recruitment domain
(CARD)/membrane-associated guanylate kinase (MAGUK) family members
that interact with BCL10 and activate NF-kappa B
JOURNAL J. Biol. Chem. 276 (15), 11877-11882 (2001)
PUBMED 11278692
REFERENCE 2 (bases 1 to 3931)
AUTHORS Bertin,J.
TITLE Direct Submission
JOURNAL Submitted (20-NOV-2000) Neurobiology, Millennium Pharmaceuticals
Inc., 640 Memorial Drive, Cambridge, MA 02139, USA
FEATURES Location/Qualifiers
source 1..3931
/db_xref="H-InvDB:HIT000077420"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 207..3221
/function="binds to Bcl10 and activates NF-kB"
/note="CARD14; CARD/MAGUK family member"
/codon_start=1
/product="caspase recruitment domain protein 14"
/protein_id="AAG53403.1"
/translation="MGELCRRDSALTALDEETLWEMMESHRHRIVRCICPSRLTPYLR
QAKVLCQLDEEEVLHSPRLTNSAMRAGHLLDLLKTRGKNGAIAFLESLKFHNPDVYTL
VTGLQPDVDFSNFSGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHL
GLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASR
CRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRS
LTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQ
KSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFEL
TDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMHAICPRDDSDCSLVSS
TESQLLSDLSATSSRELVDSFRSSSPAPPSQQSLYKRVAEDFGEEPWSFSSCLEIPEG
DPGALPGAKAGDPHLDYELLDTADLPQLESSLQPVSPGRLDVSESGVLMRRRPARRIL
SQVTMLAFQGDALLEQISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDYEASE
PLFKAVLEDTTLEEAVGLLRRVDGFCCLSVKVNTDGYKRLLQDLEAKVATSGDSFYIR
VNLAMEGRAKGELQVHCNEVLHVTDTMFQGCGCWHAHRVNSYTMKDTAAHGTIPNYSR
AQQQLIALIQDMTQQCTVTRKPSSGGPQKLVRIVSMDKAKASPLRLSFDRGQLDPSRM
EGSSTCFWAESCLTLVPYTLVWPHRPARPRPVLLVPRAVGKILSEKLCLLQGFKKCLA
EYLSQEEYEAWSQRGDIIQEGEVSGGRCWVTRHAVESLMEKNTHALLDVQLDSVCTLH
RMDIFPIVIHVSVNEKMAKKLKKGLQRLGTSEEQLLEAARQEEGDLDRAPCLYSSLAP
DGWSDLDGLLSCVRQAIADEQKKVVWTEQSPR"
misc_feature 273..533
/note="Region: CARD domain"
misc_feature 588..1433
/note="Region: coiled-coil domain"
misc_feature 1914..2165
/note="Region: PDZ domain"
misc_feature 2232..2438
/note="Region: SH3 domain"
misc_feature 2646..3203
/note="Region: GUK domain"
BASE COUNT 799 a 1187 c 1263 g 682 t
ORIGIN
1 attcggctcg agttcacctg gtgctgcttt gacttcaggc tcttccttct gcccagctcc
61 gtcccaccca gcagcccgca gagaaaggag gcagctggca ccacactggg ctttggagac
121 actgcgggga ctgtggaccc caccctgctg cacggagctc ctgcaaaagc aaacctgaga
181 accttgggtc ctcccagcgc ccagccatgg gggaactgtg ccgcagggac tccgcactca
241 cggcactgga cgaggagaca ctgtgggaga tgatggagag ccaccgccac aggatcgtac
301 gctgcatctg ccccagccgc ctcaccccct acctgcgcca ggccaaggtg ctgtgccagc
361 tggacgagga ggaggtgctg cacagccccc ggctcaccaa cagcgccatg cgggccgggc
421 acttgctgga tttgctgaag actcgaggga agaacggggc catcgccttc ctggagagcc
481 tgaagttcca caaccctgac gtctacaccc tggtcaccgg gctgcagcct gatgttgact
541 tcagtaactt tagcggtctc atggagacat ccaagctgac cgagtgcctg gctggggcca
601 tcggcagcct gcaggaggag ctgaaccagg aaaaggggca gaaggaggtg ctgctgcggc
661 ggtgccagca gctgcaggag cacctgggcc tggccgagac ccgtgccgag ggcctgcacc
721 agctggaggc tgaccacagc cgcatgaagc gtgaggttag cgcacacttc catgaggtgc
781 tgaggctgaa ggacgagatg ctcagcctct cgctgcacta tagcaatgcg ctgcaggaga
841 aggagctggc cgcctcacgc tgccgcagcc tgcaggagga gctgtatcta ctgaagcagg
901 agctgcagcg agccaacatg gtttcctcct gtgagctgga attgcaagag cagtccctga
961 ggacagccag cgaccaggag tccggggatg aggagctgaa ccgcctgaag gaggagaatg
1021 agaaactgcg ctcgctgact ttcagcctgg cggagaagga cattctggag cagagcctgg
1081 acgaggcgcg ggggagccga caggagctgg tggagcgcat ccactcgctg cgggagcggg
1141 ccgtggctgc cgagaggcag cgagagcagt actgggaaga gaaggaacag accctgctgc
1201 agttccagaa gagtaagatg gcctgccaac tctacaggga gaaggtgaat gcgctgcagg
1261 cccaggtgtg cgagctgcag aaggagcgag accaggcgta ctccgcgagg gacagtgctc
1321 agagggagat ttcccagagc ctggtggaga aggactccct ccgcaggcag gtgttcgagc
1381 tgacggacca ggtctgcgag ctgcgcacac agcttcgcca gctgcaggca gagcctccgg
1441 gtgtgctcaa gcaggaagcc aggaccaggg agccctgtcc acgggagaag cagcggctgg
1501 tgcggatgca tgccatctgc cccagagacg acagcgactg cagcctcgtc agctccacag
1561 agtctcagct cttgtcggac ctgagtgcca cgtccagccg cgagctggtg gacagcttcc
1621 gctccagcag ccccgcgccc cccagccagc agtccctgta caagcgggtg gccgaggact
1681 tcggggaaga accctggtct ttcagcagct gcctggagat cccggaggga gacccgggag
1741 ccctgccggg agctaaggca ggcgacccac acctggatta tgagctccta gacacggcag
1801 accttccgca gctggaaagc agcctgcagc cagtctcccc tggaaggctt gatgtctcgg
1861 agagcggcgt cctcatgcgg cggaggccag cccgcaggat cctgagccag gtcaccatgc
1921 tggcgttcca gggggatgca ttgctggagc agatcagcgt catcggcggg aacctcacgg
1981 gcatcttcat ccaccgggtc accccgggct cggcggcgga ccagatggcc ttgcgcccgg
2041 gcacccagat tgtgatggtt gattacgaag cctcagagcc cttgttcaag gcagtcctgg
2101 aggacacgac cctggaggag gccgtggggc ttctcaggag ggtggacggc ttctgctgcc
2161 tgtctgtgaa ggtcaacacg gacggttata agaggctact ccaggacctg gaggccaaag
2221 tggcgacctc gggggactca ttctacatcc gggtcaacct ggccatggag ggcagggcca
2281 aaggggagct gcaggtgcat tgcaacgagg tcctgcacgt caccgacacc atgttccagg
2341 gctgcggctg ctggcatgcc caccgcgtga actcttacac catgaaggat actgccgcgc
2401 acggcaccat ccccaactac tccagggctc agcagcagct catagccctc atccaggaca
2461 tgactcagca gtgcaccgtg acccgcaagc catcttctgg gggaccacag aagctggtcc
2521 gcatcgtcag tatggacaaa gccaaggcca gccctctgcg tttgtccttt gacaggggcc
2581 agttggaccc cagcaggatg gagggctcca gcacgtgctt ctgggccgag agctgcctca
2641 ccctggtgcc ctataccctg gtgtggcccc atcgacccgc ccggccccgg cctgtgctcc
2701 tcgtgcccag ggcggttggg aagatcctga gcgagaaact gtgcctcctc caagggttta
2761 agaagtgcct ggcagagtac ttgagccagg aggagtatga ggcctggagc cagagagggg
2821 acatcatcca ggagggagag gtgtccgggg gccgctgctg ggtgacccgc catgctgtgg
2881 agtccctcat ggaaaagaac acccatgccc tcctggacgt ccagctggac agtgtctgca
2941 ccctgcacag gatggacatc ttccccatcg tcatccacgt ctctgtcaac gagaagatgg
3001 caaagaagct caagaagggc ctacagcggt tgggcacctc agaggagcag ctcctggagg
3061 ctgcgaggca ggaggaggga gacctggacc gggcgccctg tctatacagc agcctggctc
3121 ctgacggctg gagcgacctg gacggcctgc tcagctgtgt ccgccaggcc atcgccgacg
3181 agcagaagaa ggtggtgtgg acggagcaga gcccccgatg atgcaccgtg ccccttcccg
3241 ggactgtggg ggcttctgtg tgcctgttaa tgcagtcctg ttcctcagcc caggccctct
3301 tggcacagct gtgggctcct tggcacatga ggccggctct ccccactggc tggggtctaa
3361 ccttgaaccc tcaccacgtg caggtcacac acagtgaagc cacttgtaac tgcacacttt
3421 tctgtggaaa catcttcacc ctttaccagg cttggcatgg tctgaactgg aaaccctgag
3481 aatgtttctg cagtaggaca ggagggacat cttcccatgc cttccctaga accggaggcc
3541 ccggacttct ctggaaaacc gcctgtctgc aggcccgatt caaatctatg ggggctgcac
3601 ttccctttta cattttgatg tgtcaaaggc ttttggagtg accaaaagca cagaggcagc
3661 gggtggggcg cctgggtggt ccccaaggtc gctgccaccc ttgcccgggg cagaggcata
3721 agcccacata tgctgtgacg ctggccacct tttctcagct tctgaggctg cgatgcctca
3781 ggaactccag tttacagaga ccagtgtgtt tacttgtaaa taaagcctct gggtggtgga
3841 gacggtactt tcagtgggtc tgtgccccgt ggcccctgtg cctgttcggt gggggtgtcc
3901 cagagaagcc tggcaccagt acccccgtca a
//