LOCUS AF233517 3593 bp mRNA linear ROD 04-OCT-2000
DEFINITION Mus musculus PD-1-ligand precursor, mRNA, complete cds.
ACCESSION AF233517
VERSION AF233517.1
KEYWORDS .
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 3593)
AUTHORS Freeman,G.J., Long,A.J., Iwai,Y., Bourque,K., Chernova,T.,
Nishimura,H., Fitz,L.J., Malenkovich,N., Okazaki,T., Byrne,M.C.,
Horton,H.F., Fouser,L., Carter,L., Ling,V., Bowman,M.R.,
Carreno,B.M., Collins,M., Wood,C.R. and Honjo,T.
TITLE Engagement of the PD-1 immunoinhibitory receptor by a novel B7
family member leads to negative regulation of lymphocyte activation
JOURNAL J. Exp. Med. 192 (7), 1027-1034 (2000)
PUBMED 11015443
REFERENCE 2 (bases 1 to 3593)
AUTHORS Freeman,G.J., Long,A.J., Iwai,Y., Bourque,K., Chernova,T.,
Nishimura,H., Fitz,L., Malenkovich,N., Okazaki,T., Byrne,M.,
Horton,H., Fouser,L., Carter,L., Carreno,B., Collins,M., Wood,C.R.
and Honjo,T.
TITLE Direct Submission
JOURNAL Submitted (11-FEB-2000) Adult Oncology, Dana-Farber Cancer
Institute, 44 Binney St., Boston, MA 02115, USA
FEATURES Location/Qualifiers
source 1..3593
/organism="Mus musculus"
/mol_type="mRNA"
/db_xref="taxon:10090"
/tissue_type="spleen"
CDS 17..889
/codon_start=1
/product="PD-1-ligand precursor"
/protein_id="AAG18509.1"
/translation="MRIFAGIIFTACCHLLRAFTITAPKDLYVVEYGSNVTMECRFPV
ERELDLLALVVYWEKEDEQVIQFVAGEEDLKPQHSNFRGRASLPKDQLLKGNAALQIT
DVKLQDAGVYCCIISYGGADYKRITLKVNAPYRKINQRISVDPATSEHELICQAEGYP
EAEVIWTNSDHQPVSGKRSVTTSRTEGMLLNVTSSLRVNATANDVFYCTFWRSQPGQN
HTAELIIPELPATHPPQNRTHWVLLGSILLFLIVVSTVLLFLRKQVRMLDVEKCGVED
TSSKNRNDTQFEET"
sig_peptide 17..70
mat_peptide 71..886
/product="PD-1-ligand"
BASE COUNT 947 a 834 c 759 g 1053 t
ORIGIN
1 agatagttcc caaaacatga ggatatttgc tggcattata ttcacagcct gctgtcactt
61 gctacgggcg tttactatca cggctccaaa ggacttgtac gtggtggagt atggcagcaa
121 cgtcacgatg gagtgcagat tccctgtaga acgggagctg gacctgcttg cgttagtggt
181 gtactgggaa aaggaagatg agcaagtgat tcagtttgtg gcaggagagg aggaccttaa
241 gcctcagcac agcaacttca gggggagagc ctcgctgcca aaggaccagc ttttgaaggg
301 aaatgctgcc cttcagatca cagacgtcaa gctgcaggac gcaggcgttt actgctgcat
361 aatcagctac ggtggtgcgg actacaagcg aatcacgctg aaagtcaatg ccccataccg
421 caaaatcaac cagagaattt ccgtggatcc agccacttct gagcatgaac taatatgtca
481 ggccgagggt tatccagaag ctgaggtaat ctggacaaac agtgaccacc aacccgtgag
541 tgggaagaga agtgtcacca cttcccggac agaggggatg cttctcaatg tgaccagcag
601 tctgagggtc aacgccacag cgaatgatgt tttctactgt acgttttgga gatcacagcc
661 agggcaaaac cacacagcgg agctgatcat cccagaactg cctgcaacac atcctccaca
721 gaacaggact cactgggtgc ttctgggatc catcctgttg ttcctcattg tagtgtccac
781 ggtcctcctc ttcttgagaa aacaagtgag aatgctagat gtggagaaat gtggcgttga
841 agatacaagc tcaaaaaacc gaaatgatac acaattcgag gagacgtaag cagtgttgaa
901 ccctctgatc gtcgattggc agcttgtggt ctgtgaaaga aagggcccat gggacatgag
961 tccaaagact caagatggaa cctgagggag agaaccaaga aagtgttggg agaggagcct
1021 ggaacaacgg acattttttc cagggagaca ctgctaagca agttgcccat cagtcgtctt
1081 gggaaatgga ttgagggttc ctggcttagc agctggtcct tgcacagtga ccttttcctc
1141 tgctcagtgc cgggatgaga gatggagtca tgagtgttga agaataagtg ccttctattt
1201 attttgagtc tgtgtgttct cactttgggc atgtaattat gactggtgaa ttctgacgac
1261 atgatagatc ttaagatgta gtcaccaaac tcaactgctg cttagcatcc tccgtaacta
1321 ctgatacaag cagggaacac agaggtcacc tgcttggttt gacaggctct tgctgtctga
1381 ctcaaataat ctttattttt cagtcctcaa ggctcttcga tagcagttgt tctgtatcag
1441 ccttataggt gtcaggtata gcactcaaca tctcatctca ttacaatagc aaccctcatc
1501 accatagcaa cagctaacct ctgttatcct cacttcatag ccaggaagct gagcgactaa
1561 gtcacttgcc cacagagtat cagctctcag atttctgttc ttcagccact gtcctttcag
1621 gatagaattt gtcgttaaga aattaattta aaaactgatt attgagtagc attgtatatc
1681 aatcacaaca tgccttgtgc actgtgctgg cctctgagca taaagatgta cgccggagta
1741 ccggtcggac atgtttatgt gtgttaaata ctcagagaaa tgttcattaa caaggagctt
1801 gcattttaga gacactggaa agtaactcca gttcattgtc tagcattaca tttacctcat
1861 ttgctatcct tgccatacag tctcttgttc tccatgaagt gtcatgaatc ttgttgaata
1921 gttcttttat tttttaaatg tttctattta aatgatattg acatctgagg cgatagctca
1981 gttggtaaaa ccctttcctc acaagtgtga aaccctgagt cttatcccta gaacccacat
2041 aaaaaacagt tgcgtatgtt tgtgcatgct tttgatccca gcactaggga ggcagaggca
2101 ggcagatcct gagctctcat tgaccaccca gcctagccta catggttagc tccaggccta
2161 caggagctgg cagagcctga aaaacgatgc ctagacacac acacacacac acacacacac
2221 acacacacac acacacacca tgtactcata gacctaagtg caccctccta cacatgcaca
2281 cacatacaat tcaaacacaa atcaacaggg aattgtctca gaatggtccc caagacaaag
2341 aagaagaaaa acaccaaacc agctctattc cctcagccta tcctctctac tccttcctag
2401 aagcaactac tattgttttt gtatataaat ttacccaacg acagttaata tgtagaatat
2461 atattaaagt gtctgtcaat atatattatc tctttctttc tttcttcctt tctttctttc
2521 tttctttctt tctttctttc tttctttctt tctttctttc ttccttcctt ccttccttcc
2581 ttccttcctt ccttcctttc tttctttctt tctttttttc tgtctatctg tacctaaatg
2641 gttgctcact atgcattttc tgtgctcttc gcccttttta tttaatgtat ggatatttat
2701 gctgcttcca gaatggatct aaagctcttt gtttctaggt tttctccccc atccttctag
2761 gcatctctca cactgtctag gccagacacc atgtctgctg cctgaatctg tagacaccat
2821 ttataaagca cgtactcacc gagtttgtat ttggcttgtt ctgtgtctga ttaaagggag
2881 accatgagtc cccagggtac actgagttac cccagtacca agggggagcc ttgtttgtgt
2941 ctccatggca gaagcaggcc tggagccatt ttggtttctt ccttgacttc tctcaaacac
3001 agacgcctca cttgctcatt acaggttctc ctttgggaat gtcagcattg ctccttgact
3061 gctggctgcc ctggaaggag cccattagct ctgtgtgagc ccttgacagc tactgcctct
3121 ccttaccaca ggggcctcta agatactgtt acctagaggt cttgaggatc tgtgttctct
3181 ggggggagga aaggaggagg aacccagaac tttcttacag ttttccttgt tctgtcacat
3241 gtcaagactg aaggaacagg ctgggctacg tagtgagatc ctgtctcaaa ggaaagacga
3301 gcatagccga acccccggtg gaaccccctc tgttacctgt tcacacaagc ttattgatga
3361 gtctcatgtt aatgtcttgt ttgtatgaag tttaagaaaa tatcgggttg ggcaacacat
3421 tctatttatt cattttattt gaaatcttaa tgccatctca tggtgttgga ttggtgtggc
3481 actttattct tttgtgttgt gtataaccat aaattttatt ttgcatcaga ttgtcaatgt
3541 attgcattaa tttaataaat atttttattt attaaaaaaa aaaaaaaaaa aaa
//