LOCUS       AF217525                6649 bp    mRNA    linear   HUM 27-OCT-2000
DEFINITION  Homo sapiens clone cDSC1 Down syndrome cell adhesion molecule
            (DSCAM) mRNA, complete cds.
ACCESSION   AF217525
VERSION     AF217525.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6649)
  AUTHORS   Agarwala,K.L., Nakamura,S., Tsutsumi,Y. and Yamakawa,K.
  TITLE     Down syndrome cell adhesion molecule DSCAM mediates homophilic
            intercellular adhesion
  JOURNAL   Brain Res. Mol. Brain Res. 79 (1-2), 118-126 (2000)
   PUBMED   10925149
REFERENCE   2  (bases 1 to 6649)
  AUTHORS   Agarwala,K.L., Suzuki,T. and Yamakawa,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-DEC-1999) Neurogenetics, RIKEN Brain Science
            Institute, 2-1, Hirosawa, Wako-shi, Saitama 351-0198, Japan
FEATURES             Location/Qualifiers
     source          1..6649
                     /db_xref="H-InvDB:HIT000074177"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.2-22.3"
                     /clone="cDSC1"
                     /note="full-length cDNA clone"
     gene            1..6649
                     /gene="DSCAM"
     CDS             479..6517
                     /gene="DSCAM"
                     /codon_start=1
                     /product="Down syndrome cell adhesion molecule"
                     /protein_id="AAF27525.1"
                     /translation="MWILALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLV
                     PCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYC
                     TAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSW
                     EKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVS
                     DPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVT
                     GLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLS
                     CSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKL
                     SAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKG
                     GSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIR
                     PMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQK
                     EVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDL
                     PITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQS
                     QLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALN
                     GRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTL
                     ATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTV
                     REDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSP
                     ITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS
                     NELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTG
                     GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVP
                     SYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTT
                     QPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASM
                     VFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVV
                     AVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM
                     KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQV
                     PPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSY
                     RLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRL
                     NLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCN
                     SAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLLLF
                     VLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLL
                     IEERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARP
                     GTNPTTRRNAKAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESD
                     SYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDT
                     SSEQLTAGTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIH
                     LPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQKSRTLKRPTVLEPIPMEAASSASSTR
                     EGQSWQPGAVATLPQREGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV"
BASE COUNT         1698 a         1830 c         1781 g         1340 t
ORIGIN      
        1 agggaaggtt ggcagaggga tccatgtgac tgaggccgga gcacggcaaa gatgagcctg
       61 cccgcccgcc tgctgcctgg atgcggaggg tgagggctgg cgcacgggag gccgctggct
      121 gcgcattctg ggcgccgagt gcccgggatg agctcacgcc cgcgtctgcg gctctctcca
      181 cctgccgacc tgccgggggc ccactgagct gacggcgcac ctgggctccg gccgcagcgt
      241 ggggcgcggc gcccgggagc aggtgtgcag gagcgcagcg cgcggcgagc gcagccctcg
      301 ctccggagcc cggccgcgcc gcgtgcccgg gcggctaggc agcggcggcg gcggcggcgg
      361 gcggcgggcg ggcggcggcc cccgggcagg tgccgagcgg cgagcggagc cgggccgggc
      421 ggagcgcggg gggcgaggcc ggcgcgtcgc tcgcgggagg ccggggagcg gcaggggcat
      481 gtggatactg gctctctcct tgttccagag cttcgcgaat gttttcagtg aagacctaca
      541 ctccagcctc tactttgtca atgcatctct gcaagaggta gtgtttgcca gcaccacggg
      601 gactctggtg ccctgccccg cagcaggcat ccctcctgtg actctcagat ggtacctagc
      661 cacgggcgag gagatctacg atgtccccgg gatccgccac gtccacccca acggcactct
      721 ccaaattttc cccttccctc cttcaagctt cagtacctta atccatgata atacttatta
      781 ttgcacagct gaaaatcctt cagggaaaat tagaagtcag gatgtccaca tcaaggctgt
      841 tttacgggag ccctatacag tccgtgtgga ggaccagaaa accatgagag gcaatgttgc
      901 ggtcttcaag tgcattatcc cctcctcggt ggaggcgtac atcactgtcg tctcatggga
      961 gaaagacact gtttcacttg tctcaggatc tagatttctc atcacatcca cgggagcctt
     1021 gtatattaaa gatgtacaga atgaagatgg attgtataac taccgctgca tcacgcggca
     1081 tcgatacacc ggagagacga ggcagagcaa cagcgccaga ctttttgtat cagacccagc
     1141 gaactcagcc ccatccatac tggatgggtt tgaccatcgc aaagccatgg ctgggcagcg
     1201 tgtggagctg ccttgcaaag cgctcgggca ccctgagcca gattaccgct ggctgaagga
     1261 caacatgccc ctggaacttt cagggaggtt ccagaagacc gtgacggggc tgctcattga
     1321 gaacattcgc ccctcggact caggcagcta tgtttgtgaa gtgtccaaca gatacggaac
     1381 tgctaaggtg ataggccgcc tgtacgtgaa acagccactg aaagccacca tcagtcccag
     1441 gaaggttaaa agcagcgtgg gtagccaagt ttccttgtcc tgcagcgtga caggaactga
     1501 ggaccaggaa ctctcctggt accgcaatgg tgaaatcctc aaccctggaa aaaatgtgag
     1561 gatcacaggg atcaaccacg aaaaccttat aatggatcac atggtcaaaa gtgacggggg
     1621 cgcataccag tgctttgtgc gcaaggacaa gctgtccgct caagactatg tgcaggtggt
     1681 ccttgaagat ggaactccca aaattatttc tgcctttagt gaaaaggtgg tgagtccagc
     1741 agagccggtt tcccttatgt gcaacgtgaa gggaacacct ttgcccacga tcacgtggac
     1801 cctggacgat gacccgattc tcaagggtgg cagtcaccgc atcagccaga tgatcacgtc
     1861 ggaggggaac gtggtcagct acctgaacat ctccagctcc caggtccggg acgggggagt
     1921 ctaccgctgc actgccaaca actcggcggg agtcgtcctg taccaggctc gaataaacgt
     1981 aagagggcct gcaagcattc gaccaatgaa aaacatcaca gcaatagcag gacgggacac
     2041 atacattcac tgtcgtgtga ttggctatcc gtattactcc attaaatggt acaagaactc
     2101 taacctgctt cctttcaacc accgccaagt ggcatttgag aacaatggaa ctcttaaact
     2161 ttcagatgtg caaaaggaag tggacgaggg ggagtacacg tgcaacgtgt tggttcaacc
     2221 acaactctcc accagccaga gcgtccacgt gaccgtgaaa gttccgcctt tcatacaacc
     2281 ctttgagttt ccaagattct ccattgggca gcgggtcttc atcccctgtg ttgtggtctc
     2341 aggggactta cccatcacga tcacctggca gaaggatggc cggccaatcc ctgggagcct
     2401 tggggtgacc attgacaata ttgacttcac gagctccttg aggatttcca atctctcgct
     2461 catgcacaat gggaattaca cctgcatagc ccggaatgag gccgccgctg tggagcacca
     2521 aagccagttg attgtcagag ttcctcccaa gtttgtggtt cagccacggg accaggacgg
     2581 gatttatggc aaagcagtca tcctcaattg ttctgctgag ggttaccctg tacctaccat
     2641 cgtgtggaaa ttctctaaag gtgctggggt tccccagttc cagccaattg ccctaaatgg
     2701 ccgaatccaa gttctcagca atgggtcgtt gctgatcaag catgtcgtgg aggaagacag
     2761 tggctactac ctctgcaagg tcagcaacga tgtgggcgca gacgtcagca agtccatgta
     2821 cctcacggtt aaaattcctg cgatgataac atcctatcca aatactaccc tggccacgca
     2881 ggggcagaaa aaggagatga gctgcacggc gcatggtgag aagcccatta tagtccgctg
     2941 ggagaaggag gaccgaatca ttaaccctga gatggcccgt tatcttgtgt ccaccaagga
     3001 ggtgggagaa gaggtgattt ctactctgca gattttgcca actgtgagag aagattctgg
     3061 tttcttttcc tgccatgcta ttaattctta tggggaggac cgtggaataa ttcagctcac
     3121 agtgcaagag cccccagacc ctcccgaaat tgagatcaaa gatgtcaaag cacgcacaat
     3181 tacgctcagg tggaccatgg ggtttgatgg aaacagtccc atcacaggct acgatattga
     3241 atgcaaaaat aaatcagact cctgggattc tgctcagaga accaaagatg tttcccctca
     3301 gctgaactcg gccaccatca ttgatatcca cccttcctcc acctacagca tccgcatgta
     3361 cgccaagaac cggattggca agagcgagcc cagcaacgag ctcaccatca cggcggacga
     3421 ggcagctcct gatggtccac ctcaggaagt tcacctggag cctatatcat ctcagagcat
     3481 cagggtcaca tggaaggctc ccaagaaaca tttgcaaaat gggattatcc gtggctacca
     3541 aataggttac cgagagtaca gcactggggg taacttccaa ttcaacatta tcagtgtcga
     3601 caccagcggg gacagtgagg tttacaccct ggacaacctg aataagttca ctcagtacgg
     3661 cctggtggtg caggcctgta accgggccgg cacggggcct tcttctcagg aaatcatcac
     3721 caccactctc gaggatgtgc ccagttaccc ccccgaaaat gtccaagcca tagcaacatc
     3781 accagaaagc atatcaatat cctggtccac actttccaag gaagccttga atggaattct
     3841 ccaggggttc agagtcattt actgggccaa cctcatggac ggagagctgg gtgagattaa
     3901 aaacatcacc accacacagc cttcactgga gctggacggg ctggaaaagt acaccaacta
     3961 cagcatccag gtgctggcct tcacccgcgc aggagacggg gtcaggagtg agcagatctt
     4021 cacccggacc aaagaggatg ttccaggtcc tcccgcgggt gtgaaggcag cggcggcctc
     4081 agcctccatg gtctttgtgt cctggcttcc ccctctcaag ctgaacggca tcatccgaaa
     4141 gtacactgta ttctgctccc acccctatcc cacagtgatc agcgagtttg aggcctctcc
     4201 cgactcgttt tcctacagaa ttcccaacct gagtaggaat cgtcagtaca gcgtctgggt
     4261 ggtggctgtt acttcagccg gaagaggcaa cagcagtgaa atcatcacag tcgagccact
     4321 agcaaaagct cctgcacgaa tcctgacctt cagtgggaca gtgactactc catggatgaa
     4381 agacattgtc ttgccttgta aggctgttgg ggacccttct cctgcagtca aatggatgaa
     4441 agacagtaac gggacaccca gtctagtaac gattgatggg cggaggagca tctttagcaa
     4501 cggaagcttc attattcgca cggtgaaagc agaagactcc ggctattaca gctgcattgc
     4561 caataacaac tggggatctg atgaaattat tttaaactta caagtacaag ttccaccaga
     4621 tcagcctcgg cttacagtct ccaagaccac gtcttcctcc atcacccttt cttggctccc
     4681 tggagacaac gggggcagct ctatcagagg atacatactg cagtactccg aggacaatag
     4741 tgagcagtgg gggagttttc caatcagccc cagcgaacgt tcctatcgct tggaaaatct
     4801 caaatgtggg acttggtata agttcacact gacagcccaa aatggagtgg gcccagggcg
     4861 cataagtgaa atcatagaag caaagacctt aggaaaagag ccccagttct caaaggagca
     4921 ggagctgttt gccagcatca acaccacacg cgtgaggctg aacctcattg gctggaatga
     4981 tggcggctgc cccatcacct ccttcacact agagtacagg ccctttggga ccacagtttg
     5041 gaccacagct cagaggacct ctctctccaa gtcctacatc ctgtatgacc tgcaggaagc
     5101 cacctggtat gagctgcaga tgcgggtgtg caacagtgcg ggctgcgcgg agaagcaggc
     5161 caacttcgct acgctgaact acgatggcag tacaattcct ccactcatta agtcagttgt
     5221 ccaaaacgaa gaagggctga cgaccaacga ggggctcaag atgctggtga ccatctcctg
     5281 tatcctggtg ggggtcttgc tgctgtttgt gctcctgctg gttgtgcgga ggaggcggcg
     5341 ggagcagagg ctaaagaggc tgcgagatgc aaagagttta gctgaaatgc tcatgagtaa
     5401 gaatacccgg acttcagata cgttaagcaa gcaacagcag accctgcgaa tgcacatcga
     5461 catacccagg gctcagcttt tgattgaaga gagagacacg atggagacca ttgatgatcg
     5521 ctccacggtt ctgttgacgg atgctgactt tggagaggca gctaagcaga agtccctgac
     5581 ggtcactcac acggtccatt accaatcggt gtctcaggcc actgggccct tagtggatgt
     5641 ttcagacgct cggccgggaa cgaatcccac caccaggagg aatgccaagg ctgggcccac
     5701 agcgagaaac cgctatgcca gccagtggac cctcaaccga ccccacccca ccatctcagc
     5761 acacaccctc accacagact ggaggctgcc aacacccagg gctgcaggat cagtagacaa
     5821 agagagcgac agttacagcg tcagcccctc gcaagacaca gatcgagcaa gaagcagcat
     5881 ggtctccaca gaaagtgcct cctccactta cgaagaactg gccagggcct acgaacacgc
     5941 caagatggaa gagcaactga ggcacgccaa gttcaccatc acggagtgct tcatatcaga
     6001 cacgtcatcg gagcagttga cggcagggac aaatgagtac acggacagtc tgacctccag
     6061 caccccttcc gaatcgggaa tctgcaggtt cactgcatct ccccccaaac ctcaggatgg
     6121 aggaagagta atgaatatgg cagttccaaa ggcacatcgg ccaggtgacc tcatacattt
     6181 gcctccatac cttagaatgg actttttgtt aaaccgaggt ggtccaggca ccagcaggga
     6241 cctgagctta ggacaagcat gcttggaacc tcagaaaagc cggaccctga agcgccccac
     6301 ggtcctggag cccatcccga tggaagccgc ctcctccgcc tcctccacga gagaaggaca
     6361 gtcgtggcag ccgggggccg tggccacatt acctcagcgg gagggagcag agctgggaca
     6421 ggcagctaaa atgagcagct cccaagaatc actgctcgac tcccggggcc atttgaaagg
     6481 aaacaatcct tacgcaaaat cttacaccct ggtataacag acagcatgac tggacagcgg
     6541 ttgtaaatac aattcaaaca attcaatcaa agctaccttt tttttacgga attccaatat
     6601 ttataattaa agaaaattgc caaaatatat taaaaaaaaa aaaaaaaaa
//