LOCUS       AF208161                2930 bp    mRNA    linear   HUM 22-FEB-2000
DEFINITION  Homo sapiens syncytin precursor, mRNA, complete cds.
ACCESSION   AF208161
VERSION     AF208161.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2930)
  AUTHORS   Mi,S., Lee,X., Li,X., Veldman,G.M., Finnerty,H., Racie,L.,
            LaVallie,E., Tang,X.Y., Edouard,P., Howes,S., Keith,J.C. Jr. and
            McCoy,J.M.
  TITLE     Syncytin is a captive retroviral envelope protein involved in human
            placental morphogenesis
  JOURNAL   Nature 403 (6771), 785-789 (2000)
   PUBMED   10693809
REFERENCE   2  (bases 1 to 2930)
  AUTHORS   Sha,M., Lee,X., Li,X., Veldman,G.M., Finnerty,H., Racie,L.,
            LaVallie,E., Tang,X., Edouard,P., Howes,S., Keith,J.C. Jr. and
            McCoy,J.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-NOV-1999) Genetics Institute, 87 Cambridge Park
            Drive, Cambridge, MA 02140, USA
FEATURES             Location/Qualifiers
     source          1..2930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="AJ172-2s"
                     /tissue_type="testis"
     repeat_region   1..2930
                     /rpt_family="Human endogeneous retrovirus HERV-W"
     5'UTR           1..929
     CDS             930..2546
                     /note="envelope protein"
                     /codon_start=1
                     /product="syncytin precursor"
                     /protein_id="AAF28334.1"
                     /translation="MALPYHIFLFTVLLPSFTLTAPPPCRCMTSSSPYQEFLWRMQRP
                     GNIDAPSYRSLSKGTPTFTAHTHMPRNCYHSATLCMHANTHYWTGKMINPSCPGGLGV
                     TVCWTYFTQTGMSDGGGVQDQAREKHVKEVISQLTRVHGTSSPYKGLDLSKLHETLRT
                     HTRLVSLFNTTLTGLHEVSAQNPTNCWICLPLNFRPYVSIPVPEQWNNFSTEINTTSV
                     LVGPLVSNLEITHTSNLTCVKFSNTTYTTNSQCIRWVTPPTQIVCLPSGIFFVCGTSA
                     YRCLNGSSESMCFLSFLVPPMTIYTEQDLYNYVISKPRNKRVPILPFVIGAGVLGALG
                     TGIGGITTSTQFYYKLSQELNGDMERVADSLVTLQDQLNSLAAVVLQNRRALDLLTAE
                     RGGTCLFLGEECCYYVNQSGIVTEKVKEIRDRIQRRAEELRNTGPWGLLSQWMPWILP
                     FLGPLAAIILLLLFGPCIFNLLVNFVSSRIEAVKLQMEPKMQSKTKIYRRPLDRPASP
                     RSDVNDIKGTPPEEISAAQPLLRPNSAGSS"
     sig_peptide     930..989
     mat_peptide     990..2543
                     /product="syncytin"
     misc_feature    1869..1880
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="furin; cleavage site"
     misc_feature    2043..2120
                     /note="Region: immunosuppresive region"
     misc_feature    2235..2357
                     /note="transmembrane region"
     3'UTR           2547..2930
BASE COUNT          842 a          800 c          571 g          717 t
ORIGIN      
        1 aatcgggctg ccttatcgcc aagctccttc aggagaacaa agaacaggcc attaccctgg
       61 agaagactgg caactgattt tacccacaag cccaaacctc agggatttca gtatctacta
      121 gtctgggtag atactttcac gggttgggca gaggccttcc cctgtaggac agaaaaggcc
      181 caagaggtaa taaaggcact agttcatgaa ataattccca gattcggact tccccgaggc
      241 ttacagagtg acaatagccc tgctttccag gccacagtaa cccagggagt atcccaggcg
      301 ttaggtatac gatatcactt acactgcgcc tgaaggccac agtcctcagg gaaggtcgag
      361 aaaatgaatg aaacactcaa aggacatcta aaaaagcaaa cccaggaaac ccacctcaca
      421 tggcctgctc tgttgcctat agccttaaaa agaatctgca actttcccca aaaagcagga
      481 cttagcccat acgaaatgct gtatggaagg cccttcataa ccaatgacct tgtgcttgac
      541 ccaagacagc caacttagtt gcagacatca cctccttagc caaatatcaa caagttctta
      601 aaacattaca aggaacctat ccctgagaag agggaaaaga actattccac ccttgtgaca
      661 tggtattagt caagtccctt ccctctaatt ccccatccct agatacatcc tgggaaggac
      721 cctacccagt cattttatct accccaactg cggttaaagt ggctggagtg gagtcttgga
      781 tacatcacac ttgagtcaaa tcctggatac tgccaaagga acctgaaaat ccaggagaca
      841 acgctagcta ttcctgtgaa cctctagagg atttgcgcct gctcttcaaa caacaaccag
      901 gaggaaagta actaaaatca taaatcccca tggccctccc ttatcatatt tttctcttta
      961 ctgttctttt accctctttc actctcactg caccccctcc atgccgctgt atgaccagta
     1021 gctcccctta ccaagagttt ctatggagaa tgcagcgtcc cggaaatatt gatgccccat
     1081 cgtataggag tctttctaag ggaaccccca ccttcactgc ccacacccat atgccccgca
     1141 actgctatca ctctgccact ctttgcatgc atgcaaatac tcattattgg acaggaaaaa
     1201 tgattaatcc tagttgtcct ggaggacttg gagtcactgt ctgttggact tacttcaccc
     1261 aaactggtat gtctgatggg ggtggagttc aagatcaggc aagagaaaaa catgtaaaag
     1321 aagtaatctc ccaactcacc cgggtacatg gcacctctag cccctacaaa ggactagatc
     1381 tctcaaaact acatgaaacc ctccgtaccc atactcgcct ggtaagccta tttaatacca
     1441 ccctcactgg gctccatgag gtctcggccc aaaaccctac taactgttgg atatgcctcc
     1501 ccctgaactt caggccatat gtttcaatcc ctgtacctga acaatggaac aacttcagca
     1561 cagaaataaa caccacttcc gttttagtag gacctcttgt ttccaatctg gaaataaccc
     1621 atacctcaaa cctcacctgt gtaaaattta gcaatactac atacacaacc aactcccaat
     1681 gcatcaggtg ggtaactcct cccacacaaa tagtctgcct accctcagga atattttttg
     1741 tctgtggtac ctcagcctat cgttgtttga atggctcttc agaatctatg tgcttcctct
     1801 cattcttagt gccccctatg accatctaca ctgaacaaga tttatacaat tatgtcatat
     1861 ctaagccccg caacaaaaga gtacccattc ttccttttgt tataggagca ggagtgctag
     1921 gtgcactagg tactggcatt ggcggtatca caacctctac tcagttctac tacaaactat
     1981 ctcaagaact aaatggggac atggaacggg tcgccgactc cctggtcacc ttgcaagatc
     2041 aacttaactc cctagcagca gtagtccttc aaaatcgaag agctttagac ttgctaaccg
     2101 ctgaaagagg gggaacctgt ttatttttag gggaagaatg ctgttattat gttaatcaat
     2161 ccggaatcgt cactgagaaa gttaaagaaa ttcgagatcg aatacaacgt agagcagagg
     2221 agcttcgaaa cactggaccc tggggcctcc tcagccaatg gatgccctgg attctcccct
     2281 tcttaggacc tctagcagct ataatattgc tactcctctt tggaccctgt atctttaacc
     2341 tccttgttaa ctttgtctct tccagaatcg aagctgtaaa actacaaatg gagcccaaga
     2401 tgcagtccaa gactaagatc taccgcagac ccctggaccg gcctgctagc ccacgatctg
     2461 atgttaatga catcaaaggc acccctcctg aggaaatctc agctgcacaa cctctactac
     2521 gccccaattc agcaggaagc agttagagcg gtcgtcggcc aacctcccca acagcactta
     2581 ggttttcctg ttgagatggg ggactgagag acaggactag ctggatttcc taggctgact
     2641 aagaatccct aagcctagct gggaaggtga ccacatccac ctttaaacac ggggcttgca
     2701 acttagctca cacctgacca atcagagagc tcactaaaat gctaattagg caaaaacagg
     2761 aggtaaagaa atagccaatc atctattgcc tgagagcaca gcaggaggga caatgatcgg
     2821 gatataaacc caagtcttcg agccggcaac ggcaaccccc tttgggtccc ctccctttgt
     2881 atgggagctc tgttttcatg ctatttcact ctattaaatc ttgcaactgc
//