LOCUS       AF190725                2526 bp    mRNA    linear   HUM 26-OCT-1999
DEFINITION  Homo sapiens beta-site APP cleaving enzyme (BACE) mRNA, complete
            cds.
ACCESSION   AF190725
VERSION     AF190725.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2526)
  AUTHORS   Vassar,R., Bennett,B.D., Babu-Khan,S., Kahn,S., Mendiaz,E.A.,
            Denis,P., Teplow,D.B., Ross,S., Amarante,P., Loeloff,R., Luo,Y.,
            Fisher,S., Fuller,J., Edenson,S., Lile,J., Jarosinski,M.A.,
            Biere,A.L., Curran,E., Burgess,T., Louis,J.C., Collins,F.,
            Treanor,J., Rogers,G. and Citron,M.
  TITLE     Beta-secretase cleavage of Alzheimer's amyloid precursor protein by
            the transmembrane aspartic protease BACE
  JOURNAL   Science 286 (5440), 735-741 (1999)
   PUBMED   10531052
REFERENCE   2  (bases 1 to 2526)
  AUTHORS   Bennett,B.D., Vassar,R. and Citron,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-SEP-1999) Neuroscience, Amgen Inc., One Amgen Center
            Dr., Thousand Oaks, CA 91320-1799, USA
FEATURES             Location/Qualifiers
     source          1..2526
                     /db_xref="H-InvDB:HIT000073238"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     gene            1..2526
                     /gene="BACE"
     CDS             454..1959
                     /gene="BACE"
                     /codon_start=1
                     /product="beta-site APP cleaving enzyme"
                     /protein_id="AAF04142.1"
                     /translation="MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLP
                     RETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVG
                     AAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANI
                     AAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGA
                     GFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKM
                     DCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAG
                     TTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT
                     VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQT
                     DESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK"
BASE COUNT          534 a          781 c          715 g          496 t
ORIGIN      
        1 ccacgcgtcc gcagcccgcc cgggagctgc gagccgcgag ctggattatg gtggcctgag
       61 cagccaacgc agccgcagga gcccggagcc cttgcccctg cccgcgccgc cgcccgccgg
      121 ggggaccagg gaagccgcca ccggcccgcc atgcccgccc ctcccagccc cgccgggagc
      181 ccgcgcccgc tgcccaggct ggccgccgcc gtgccgatgt agcgggctcc ggatcccagc
      241 ctctcccctg ctcccgtgct ctgcggatct cccctgaccg ctctccacag cccggacccg
      301 ggggctggcc cagggccctg caggccctgg cgtcctgatg cccccaagct ccctctcctg
      361 agaagccacc agcaccaccc agacttgggg gcaggcgcca gggacggacg tgggccagtg
      421 cgagcccaga gggcccgaag gccggggccc accatggccc aagccctgcc ctggctcctg
      481 ctgtggatgg gcgcgggagt gctgcctgcc cacggcaccc agcacggcat ccggctgccc
      541 ctgcgcagcg gcctgggggg cgcccccctg gggctgcggc tgccccggga gaccgacgaa
      601 gagcccgagg agcccggccg gaggggcagc tttgtggaga tggtggacaa cctgaggggc
      661 aagtcggggc agggctacta cgtggagatg accgtgggca gccccccgca gacgctcaac
      721 atcctggtgg atacaggcag cagtaacttt gcagtgggtg ctgcccccca ccccttcctg
      781 catcgctact accagaggca gctgtccagc acataccggg acctccggaa gggtgtgtat
      841 gtgccctaca cccagggcaa gtgggaaggg gagctgggca ccgacctggt aagcatcccc
      901 catggcccca acgtcactgt gcgtgccaac attgctgcca tcactgaatc agacaagttc
      961 ttcatcaacg gctccaactg ggaaggcatc ctggggctgg cctatgctga gattgccagg
     1021 cctgacgact ccctggagcc tttctttgac tctctggtaa agcagaccca cgttcccaac
     1081 ctcttctccc tgcagctttg tggtgctggc ttccccctca accagtctga agtgctggcc
     1141 tctgtcggag ggagcatgat cattggaggt atcgaccact cgctgtacac aggcagtctc
     1201 tggtatacac ccatccggcg ggagtggtat tatgaggtga tcattgtgcg ggtggagatc
     1261 aatggacagg atctgaaaat ggactgcaag gagtacaact atgacaagag cattgtggac
     1321 agtggcacca ccaaccttcg tttgcccaag aaagtgtttg aagctgcagt caaatccatc
     1381 aaggcagcct cctccacgga gaagttccct gatggtttct ggctaggaga gcagctggtg
     1441 tgctggcaag caggcaccac cccttggaac attttcccag tcatctcact ctacctaatg
     1501 ggtgaggtta ccaaccagtc cttccgcatc accatccttc cgcagcaata cctgcggcca
     1561 gtggaagatg tggccacgtc ccaagacgac tgttacaagt ttgccatctc acagtcatcc
     1621 acgggcactg ttatgggagc tgttatcatg gagggcttct acgttgtctt tgatcgggcc
     1681 cgaaaacgaa ttggctttgc tgtcagcgct tgccatgtgc acgatgagtt caggacggca
     1741 gcggtggaag gcccttttgt caccttggac atggaagact gtggctacaa cattccacag
     1801 acagatgagt caaccctcat gaccatagcc tatgtcatgg ctgccatctg cgccctcttc
     1861 atgctgccac tctgcctcat ggtgtgtcag tggcgctgcc tccgctgcct gcgccagcag
     1921 catgatgact ttgctgatga catctccctg ctgaagtgag gaggcccatg ggcagaagat
     1981 agagattccc ctggaccaca cctccgtggt tcactttggt cacaagtagg agacacagat
     2041 ggcacctgtg gccagagcac ctcaggaccc tccccaccca ccaaatgcct ctgccttgat
     2101 ggagaaggaa aaggctggca aggtgggttc cagggactgt acctgtagga aacagaaaag
     2161 agaagaaaga agcactctgc tggcgggaat actcttggtc acctcaaatt taagtcggga
     2221 aattctgctg cttgaaactt cagccctgaa cctttgtcca ccattccttt aaattctcca
     2281 acccaaagta ttcttctttt cttagtttca gaagtactgg catcacacgc aggttacctt
     2341 ggcgtgtgtc cctgtggtac cctggcagag aagagaccaa gcttgtttcc ctgctggcca
     2401 aagtcagtag gagaggatgc acagtttgct atttgcttta gagacaggga ctgtataaac
     2461 aagcctaaca ttggtgcaaa gattgcctct tgaattaaaa aaaaaaacta gaaaaaaaaa
     2521 aaaaaa
//