LOCUS       AF117907                5874 bp    mRNA    linear   HUM 18-MAY-1999
DEFINITION  Homo sapiens tetrodotoxin-resistant voltage-gated sodium channel
            (SCN10A) mRNA, complete cds.
ACCESSION   AF117907
VERSION     AF117907.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5874)
  AUTHORS   Rabert,D.K., Koch,B.D., Ilnicka,M., Obernolte,R.A., Naylor,S.L.,
            Herman,R.C., Eglen,R.M., Hunter,J.C. and Sangameswaran,L.
  TITLE     A tetrodotoxin-resistant voltage-gated sodium channel from human
            dorsal root ganglia, hPN3/SCN10A
  JOURNAL   Pain 78 (2), 107-114 (1998)
   PUBMED   9839820
REFERENCE   2  (bases 1 to 5874)
  AUTHORS   Rabert,D.K., Koch,B.D., Ilnicka,M., Obernolte,R.A., Naylor,S.L.,
            Herman,R.C., Eglen,R.M., Hunter,J.C. and Sangameswaran,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JAN-1999) Target Identification, Roche Bioscience,
            3401 Hillview, Palo Alto, CA 94304, USA
FEATURES             Location/Qualifiers
     source          1..5874
                     /db_xref="H-InvDB:HIT000070126"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.2-p22"
                     /tissue_type="dorsal root ganglia"
     gene            1..5874
                     /gene="SCN10A"
     CDS             1..5871
                     /gene="SCN10A"
                     /note="SCN10A/PN3"
                     /codon_start=1
                     /product="tetrodotoxin-resistant voltage-gated sodium
                     channel"
                     /protein_id="AAD30863.1"
                     /db_xref="GI:4838145"
                     /translation="MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQ
                     KDQEEKPRPQLDLKACNQLPKFYGELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTIS
                     RFSATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYVF
                     TVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFR
                     VLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKC
                     VKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDF
                     NYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLI
                     LAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPL
                     TSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFR
                     SPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSPLPQPSNPDSRHGE
                     DEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVLEEL
                     EESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFM
                     AMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVS
                     LLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIV
                     FVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWA
                     CMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVAL
                     ARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAENHIAANTARGSSG
                     GLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQ
                     EQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQAPAEGVDDTSSSEGST
                     VDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCY
                     RIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLK
                     WVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALS
                     RFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSL
                     VPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVD
                     SREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMT
                     EEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMM
                     VETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIA
                     SLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNI
                     GLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLS
                     PILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIVVNMYIAVILENFN
                     VATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNI
                     LIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPI
                     ATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVAFTAN
                     ENCVLPDKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEATSMELIAPGP"
BASE COUNT         1434 a         1552 c         1428 g         1460 t
ORIGIN      
        1 atggaattcc ccattggatc cctcgaaact aacaacttcc gtcgctttac tccggagtca
       61 ctggtggaga tagagaagca aattgctgcc aagcagggaa caaagaaagc cagagagaag
      121 catagggagc agaaggacca agaagagaag cctcggcccc agctggactt gaaagcctgc
      181 aaccagctgc ccaagttcta tggtgagctc ccagcagaac tgatcgggga gcccctggag
      241 gatctagatc cgttctacag cacacaccgg acatttatgg tgctgaacaa agggaggacc
      301 atttcccggt ttagtgccac tcgggccctg tggctattca gtcctttcaa cctgatcaga
      361 agaacggcca tcaaagtgtc tgtccactcg tggttcagtt tatttattac ggtcactatt
      421 ttggttaatt gtgtgtgcat gacccgaact gaccttccag agaaaattga atatgtcttc
      481 actgtcattt acacctttga agccttgata aagatactgg caagaggatt ttgtctaaat
      541 gagttcacgt acctgagaga tccttggaac tggctggatt ttagcgtcat taccctggca
      601 tatgttggca cagcaataga tctccgtggg atctcaggcc tgcggacatt cagagttctt
      661 agagcattaa aaacagtttc tgtgatccca ggcctgaagg tcattgtggg ggccctgatt
      721 cactcagtga agaaactggc tgatgtgacc atcctcacca tcttctgcct aagtgttttt
      781 gccttggtgg ggctgcaact cttcaagggc aacctcaaaa ataaatgtgt caagaatgac
      841 atggctgtca atgagacaac caactactca tctcacagaa aaccagatat ctacataaat
      901 aagcgaggca cttctgaccc cttactgtgt ggcaatggat ctgactcagg ccactgccct
      961 gatggttata tctgccttaa aacttctgac aacccggatt ttaactacac cagctttgat
     1021 tcctttgctt gggctttcct ctcactgttc cgcctcatga cacaggattc ctgggaacgc
     1081 ctctaccagc agaccctgag gacttctggg aaaatctata tgatcttttt tgtgctcgta
     1141 atcttcctgg gatctttcta cctggtcaac ttgatcttgg ctgtagtcac catggcgtat
     1201 gaggagcaga accaggcaac cactgatgaa attgaagcaa aggagaagaa gttccaggag
     1261 gccctcgaga tgctccggaa ggagcaggag gtgctagcag cactagggat tgacacaacc
     1321 tctctccact cccacaatgg atcaccttta acctccaaaa atgccagtga gagaaggcat
     1381 agaataaagc caagagtgtc agagggctcc acagaagaca acaaatcacc ccgctctgat
     1441 ccttacaacc agcgcaggat gtcttttcta ggcctcgcct ctggaaaacg ccgggctagt
     1501 catggcagtg tgttccattt ccggtcccct ggccgagata tctcactccc tgagggagtc
     1561 acagatgatg gagtctttcc tggagaccac gaaagccatc ggggctctct gctgctgggt
     1621 gggggtgctg gccagcaagg ccccctccct agaagccctc ttcctcaacc cagcaaccct
     1681 gactccaggc atggagaaga tgaacaccaa ccgccgccca ctagtgagct tgcccctgga
     1741 gctgtcgatg tctcggcatt cgatgcagga caaaagaaga ctttcttgtc agcagaatac
     1801 ttagatgaac ctttccgggc ccaaagggca atgagtgttg tcagtatcat aacctccgtc
     1861 cttgaggaac tcgaggagtc tgaacagaag tgcccaccct gcttgaccag cttgtctcag
     1921 aagtatctga tctgggattg ctgccccatg tgggtgaagc tcaagacaat tctctttggg
     1981 cttgtgacgg atccctttgc agagctcacc atcaccttgt gcatcgtggt gaacaccatc
     2041 ttcatggcca tggagcacca tggcatgagc cctaccttcg aagccatgct ccagataggc
     2101 aacatcgtct ttaccatatt ttttactgct gaaatggtct tcaaaatcat tgccttcgac
     2161 ccatactatt atttccagaa gaagtggaat atctttgact gcatcatcgt cactgtgagt
     2221 ctgctagagc tgggcgtggc caagaaggga agcctgtctg tgctgcggag cttccgcttg
     2281 ctgcgcgtat tcaagctggc caaatcctgg cccaccttaa acacactcat caagatcatc
     2341 ggaaactcag tgggggcact ggggaacctc accatcatcc tggccatcat tgtctttgtc
     2401 tttgctctgg ttggcaagca gctcctaggg gaaaactacc gtaacaaccg aaaaaatatc
     2461 tccgcgcccc atgaagactg gccccgctgg cacatgcacg acttcttcca ctctttcctc
     2521 attgtcttcc gtatcctctg tggagagtgg attgagaaca tgtgggcctg catggaagtt
     2581 ggccaaaaat ccatatgcct catccttttc ttgacggtga tggtgctagg gaacctggtg
     2641 gtgcttaacc tgttcatcgc cctgctattg aactctttca gtgctgacaa cctcacagcc
     2701 ccggaggacg atggggaggt gaacaacctg caggtggccc tggcacggat ccaggtcttt
     2761 ggccatcgta ccaaacaggc tctttgcagc ttcttcagca ggtcctgccc attcccccag
     2821 cccaaggcag agcctgagct ggtggtgaaa ctcccactct ccagctccaa ggctgagaac
     2881 cacattgctg ccaacactgc cagggggagc tctggagggc tccaagctcc cagaggcccc
     2941 agggatgagc acagtgactt catcgctaat ccgactgtgt gggtctctgt gcccattgct
     3001 gagggtgaat ctgatcttga tgacttggag gatgatggtg gggaagatgc tcagagcttc
     3061 cagcaggaag tgatccccaa aggacagcag gagcagctgc agcaagtcga gaggtgtggg
     3121 gaccacctga cacccaggag cccaggcact ggaacatctt ctgaggacct ggctccatcc
     3181 ctgggtgaga cgtggaaaga tgagtctgtt cctcaggccc ctgctgaggg agtggacgac
     3241 acaagctcct ctgagggcag cacggtggac tgcctagatc ctgaggaaat cctgaggaag
     3301 atccctgagc tggcagatga cctggaagaa ccagatgact gcttcacaga aggatgcatt
     3361 cgccactgtc cctgctgcaa actggatacc accaagagtc catgggatgt gggctggcag
     3421 gtgcgcaaga cttgctaccg tatcgtggag cacagctggt ttgagagctt catcatcttc
     3481 atgatcctgc tcagcagtgg atctctggcc tttgaagact attacctgga ccagaagccc
     3541 acggtgaaag ctttgctgga gtacactgac agggtcttca cctttatctt tgtgttcgag
     3601 atgctgctta agtgggtggc ctatggcttc aaaaagtact tcaccaatgc ctggtgctgg
     3661 ctggacttcc tcattgtgaa tatctcactg ataagtctca cagcgaagat tctggaatat
     3721 tctgaagtgg ctcccatcaa agcccttcga acccttcgcg ctctgcggcc actgcgggct
     3781 ctttctcgat ttgaaggcat gcgggtggtg gtggatgccc tggtgggcgc catcccatcc
     3841 atcatgaatg tcctcctcgt ctgcctcatc ttctggctca tcttcagcat catgggtgtg
     3901 aacctcttcg cagggaagtt ttggaggtgc atcaactata ccgatggaga gttttccctt
     3961 gtacctttgt cgattgtgaa taacaagtct gactgcaaga ttcaaaactc cactggcagc
     4021 ttcttctggg tcaatgtgaa agtcaacttt gataatgttg caatgggtta ccttgcactt
     4081 ctgcaggtgg caacctttaa aggctggatg gacattatgt atgcagctgt tgattcccgg
     4141 gaggtcaaca tgcaacccaa gtgggaggac aacgtgtaca tgtatttgta ctttgtcatc
     4201 ttcatcattt ttggaggctt cttcacactg aatctctttg ttggggtcat aattgacaac
     4261 ttcaatcaac agaaaaaaaa gttagggggc caggacatct tcatgacaga ggagcagaag
     4321 aaatactaca atgccatgaa gaagttgggc tccaagaagc cccagaagcc catcccacgg
     4381 cccctgaaca agttccaggg ttttgtcttt gacatcgtga ccagacaagc ttttgacatc
     4441 accatcatgg tcctcatctg cctcaacatg atcaccatga tggtggagac tgatgaccaa
     4501 agtgaagaaa agacgaaaat tctgggcaaa atcaaccagt tctttgtggc cgtcttcaca
     4561 ggcgaatgtg tcatgaagat gttcgctttg aggcagtact acttcacaaa tggctggaat
     4621 gtgtttgact tcattgtggt ggttctctcc attgcgagcc tgattttttc tgcaattctt
     4681 aagtcacttc aaagttactt ctccccaacg ctcttcagag tcatccgcct ggcccgaatt
     4741 ggccgcatcc tcagactgat ccgagcggcc aaggggatcc gcacactgct ctttgccctc
     4801 atgatgtccc tgcctgccct cttcaacatc gggctgttgc tattccttgt catgttcatc
     4861 tactccatct tcggtatgtc cagctttccc catgtgaggt gggaggctgg catcgacgac
     4921 atgttcaact tccagacctt cgccaacagc atgctgtgcc tcttccagat taccacgtcg
     4981 gccggctggg atggcctcct cagccccatc ctcaacacag ggccccccta ctgtgacccc
     5041 aatctgccca acagcaatgg caccagaggg gactgtggga gcccagccgt aggcatcatc
     5101 ttcttcacca cctacatcat catctccttc ctcatcgtgg tcaacatgta cattgcagtg
     5161 attctggaga acttcaatgt ggccacggag gagagcactg agcctctgag tgaggacgac
     5221 tttgacatgt tctatgagac ctgggagaag tttgacccag aggccactca gtttattacc
     5281 ttttctgctc tctcggactt tgcagacact ctctctggtc ccctgagaat cccaaaaccc
     5341 aatcgaaata tactgatcca gatggacctg cctttggtcc ctggagataa gatccactgc
     5401 ttggacatcc tttttgcttt caccaagaat gtcctaggag aatccgggga gttggattct
     5461 ctgaaggcaa atatggagga gaagtttatg gcaactaatc tttcaaaatc atcctatgaa
     5521 ccaatagcaa ccactctccg atggaagcaa gaagacattt cagccactgt cattcaaaag
     5581 gcctatcgga gctatgtgct gcaccgctcc atggcactct ctaacacccc atgtgtgccc
     5641 agagctgagg aggaggctgc atcactccca gatgaaggtt ttgttgcatt cacagcaaat
     5701 gaaaattgtg tactcccaga caaatctgaa actgcttctg ccacatcatt cccaccgtcc
     5761 tatgagagtg tcactagagg ccttagtgat agagtcaaca tgaggacatc tagctcaata
     5821 caaaatgaag atgaagccac cagtatggag ctgattgccc ctgggcccta gtga
//