LOCUS AF084521 5860 bp mRNA linear HUM 14-JUN-1999
DEFINITION Homo sapiens brefeldin A-inhibited guanine nucleotide-exchange
protein 2 mRNA, complete cds.
ACCESSION AF084521
VERSION AF084521.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5860)
AUTHORS Togawa,A., Morinaga,N., Ogasawara,M., Moss,J. and Vaughan,M.
TITLE Purification and cloning of a brefeldin A-inhibited guanine
nucleotide-exchange protein for ADP-ribosylation factors
JOURNAL J. Biol. Chem. 274 (18), 12308-12315 (1999)
PUBMED 10212200
REFERENCE 2 (bases 1 to 5860)
AUTHORS Togawa,A., Morinaga,N., Ogasawara,M., Moss,J. and Vaughan,M.
TITLE Direct Submission
JOURNAL Submitted (18-AUG-1998) National Heart, Lung, and Blood Institute,
National Institutes of Health, 9000 Rockville Pike, Bethesda, MD
20892, USA
FEATURES Location/Qualifiers
source 1..5860
/db_xref="H-InvDB:HIT000066632"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="brain"
CDS 1..5358
/codon_start=1
/product="brefeldin A-inhibited guanine
nucleotide-exchange protein 2"
/protein_id="AAD38428.1"
/translation="MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIK
AEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITG
NAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTIL
QTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARRLEKPIQSKPQS
PVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDAPRERGS
SLSGTDDGAQEVVKDILEDVVTSAIKEAAEKHGLTEPERVLGELECQECAIPPGVDEN
SQTNGIADDRQSLSSADNLESDAQGHQVAARFSHVLQKDAFLVFRSLCKLSMKPLGEG
PPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPD
VFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICA
DAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLEC
LVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQEIGDGKGLDMARRCSVTSMESTVSS
GTQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFL
HQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQ
KIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYI
KMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQNVASEKQRRLLY
NLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDD
TEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITKMKQKNIDTIK
TLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTL
AGEEFMGLGLGNLVSGGVNKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIV
DFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVG
CNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAI
RCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPA
AIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAP
GDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIV
FRIFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCV
KQDNEQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGM
EEDSSEKHLDVDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRPYANQKLFASLLIK
CVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSSQH
LFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFR
MYVDENRRDSWEEIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDE
KFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRISVVYKIWIPEEPSQVPAALSPV
W"
BASE COUNT 1642 a 1351 c 1425 g 1442 t
ORIGIN
1 atgcaggaga gccagaccaa gagcatgttc gtgtcccggg ccctggagaa gatcctagcc
61 gacaaggagg tgaagcggcc ccagcactcc cagctgcgca gggcctgcca ggtggcgctc
121 gatgaaatta aagcagaaat agaaaagcag aggcttggca ctgctgcacc accaaaggca
181 aacttcattg aagctgacaa gtattttctt ccattcgagc tagcttgcca gtccaagtcc
241 ccaagggtag tcagcacatc ccttgactgc ttgcagaaac tcatcgcata cgggcacatc
301 actggcaacg cccctgacag tggagcccct gggaagcggc tgatcgacag aattgttgaa
361 accatttgca gttgttttca gggccctcag actgatgaag gggttcagtt acaaataatt
421 aaggctcttc tgactgcagt gacttcccca cacattgaaa ttcatgaggg tactatcctg
481 cagacagtga gaacatgtta caatatctat ttggccagca aaaatctcat caatcaaacc
541 actgccaagg ctacccttac tcagatgctg aacgtcattt tcacccgcat ggaaaaccaa
601 gtgttgcagg aggccagaag actggaaaaa ccaatccagt caaaacccca gtcccctgtg
661 atccaagctg cagcagtatc cccaaagttc gttcgtttga agcacagtca ggcacaaagc
721 aaaccaacaa ctcccgaaaa aacagattta accaacggtg aacatgccag gagtgattct
781 ggaaaagtaa gcacagaaaa tggagacgca cccagagaaa gaggctcatc actgtcaggg
841 actgatgacg gagcccagga ggtggtgaag gacatcttgg aagatgtagt cacatctgcc
901 attaaagaag cagcggaaaa gcatggtctg acagaacctg agagagttct aggtgaactg
961 gagtgccagg aatgtgctat tcccccagga gttgatgaaa actcacagac caacgggata
1021 gccgatgaca ggcagtcctt gtcgtcagca gataatctgg aatcggatgc acaaggacat
1081 caagtggctg ccaggttctc ccacgttctg cagaaggatg ccttccttgt gttccgctcc
1141 ctgtgcaagc tgtccatgaa accccttggt gaaggccctc cagacccaaa atcccatgag
1201 ctgcgttcca aggtggtttc cctgcagctg ctcctctctg tgttgcaaaa tgctggcccc
1261 gtattcagga ctcacgagat gttcatcaat gcaatcaagc aatatctctg tgtggccttg
1321 tccaaaaacg gcgtctcttc agtgcctgat gtctttgagc tctctcttgc catttttctt
1381 actcttcttt caaactttaa aatgcacttg aaaatgcaga tagaggtctt tttcaaagag
1441 attttcctga acattttaga aacatcaaca agttcttttg agcacaggtg gatggtcatt
1501 cagactctga cgaggatctg tgcagatgcc cagtgtgttg tggatattta tgtcaactac
1561 gactgtgatt taaatgctgc taacattttt gagcgccttg taaatgattt atccaaaatt
1621 gctcagggaa gaagtggaca tgagctggga atgacacctc tgcaggagct cagcctgagg
1681 aagaaaggcc tggagtgcct cgtgtccatt ctcaagtgca tggtggagtg gagcaaagac
1741 ctgtatgtga atcccaacca ccagaccagc ctcggtcagg agaggctcac ggatcaggaa
1801 ataggggatg ggaaaggcct tgacatggca agacggtgta gtgtgacgtc catggagtcc
1861 acagtgtcct cggggaccca gacaactgtt caggatgacc ctgagcaatt tgaggtcatc
1921 aagcaacaaa aagaaatcat tgaacacggc atcgagctgt tcaacaagaa acccaagagg
1981 gggatccagt ttctccagga gcagggcatg ctgggaacgt cagttgaaga catagcccaa
2041 ttcctgcacc aggaggagcg cctggattcc acccaagtag gcgattttct gggagatagc
2101 gcaaggttca acaaggaggt gatgtatgcc tacgtggacc aacttgactt ctgtgaaaaa
2161 gaatttgtct cagccctgcg gacattccta gaaggtttcc gcctacctgg agaagcccaa
2221 aagattgacc gattaatgga gaagtttgcc gcaagataca tagaatgcaa ccaagggcaa
2281 actctgtttg ctagtgctga cactgcttat gtcctagcgt attcaattat tatgctgact
2341 acagacttgc acagtcctca ggtaaaaaat aaaatgacga aagagcagta tattaaaatg
2401 aatcggggta tcaatgatag taaagatctg ccagaagagt atctctcaag catctatgaa
2461 gagatagaag gcaagaaaat tgcaatgaaa gaaacaaaag agctaacgat tgcaaccaaa
2521 tctactaagc agaatgtagc tagtgaaaag cagcggcggc tgctgtacaa cttagagatg
2581 gagcaaatgg ctaaaacagc caaagctctg atggaggctg tgagccatgc caaagccccg
2641 tttaccagtg ccactcacct ggaccatgtc cggccaatgt tcaaactggt gtggacgcca
2701 ctattggcag cctacagcat cggactccag aactgtgatg acactgaagt ggcctccttg
2761 tgtttggaag gcatccgatg tgcaatccga atcgcctgca tctttggaat gcagctggaa
2821 cgagatgcct atgttcaggc tcttgctcgc ttctccctac tcacagccag ctccagcatc
2881 acaaaaatga agcagaaaaa catcgacacc attaagacgc ttatcacagt ggctcacacc
2941 gatggcaact accttgggaa ttcctggcat gagatcttga aatgcatcag ccagctggag
3001 ctcgctcagc tgataggaac cggtgtgaag acgcgctacc tgtctggatc tgggcgtgaa
3061 agagaaggga gcctgaaggg ccacacattg gcaggagaag agttcatggg ccttggcctc
3121 ggtaatttgg tgagtggcgg agtgaataaa agacagatgg ccagcttcca agaatcggtt
3181 ggtgagacca gctcgcagag tgtggttgta gctgtggaca ggatttttac tgggtctacc
3241 agactggatg gaaatgcaat agttgacttt gtccgctggc tgtgtgctgt gtccatggat
3301 gaactggctt ccccccacca tcctcgcatg ttcagcttgc agaagattgt ggagatatca
3361 tactacaaca tgaatcggat ccgactacag tggtctcgaa tatggcatgt gattggagat
3421 cacttcaata aggttggctg caaccctaat gaagatgtgg ctatctttgc tgttgactca
3481 ttaaggcaac tctccatgaa gtttcttgag aagggtgaat tagccaactt ccgtttccag
3541 aaagattttc tgaggccctt tgagcatatt atgaagaaaa acaggtctcc caccatccgg
3601 gacatggcga tccgctgcat tgcccagatg gtgaactccc aggcggccaa catccgctca
3661 ggctggaaga acatctttgc cgtgttccac caggcagcct ctgatcatga tgggaacatt
3721 gtggagctgg ccttccagac cacttgccac attgtcacaa ctattttcca gcaccatttt
3781 cctgcagcca tcgattcctt tcaggatgct gtgaagtgct tatcagagtt cgcctgcaac
3841 gccgctttcc ctgacacgag catggaagcg attcggctca tccgcttctg tggcaaatac
3901 gtctctgaga ggcctcgggt gctacaagaa tacacaagtg atgacatgaa tgtagctcct
3961 ggtgacagag tctgggtccg aggctggttc cccatcttat tcgaactctc ctgcatcatt
4021 aatagatgca agttagatgt acgaacaagg ggactcacag tcatgtttga gatcatgaag
4081 agctatggcc acacctttga aaagcactgg tggcaggacc tgttcagaat cgtgtttcgg
4141 atttttgaca atatgaaact ccctgagcaa ctgtcagaga aatctgagtg gatgacaaca
4201 acctgcaatc acgcacttta tgctatttgt gatgttttta cccagtttta tgaagctttg
4261 aatgaagttc ttctttctga tgtatttgca caattgcagt ggtgtgtcaa acaagataat
4321 gaacagttgg cgcgatcagg tacaaattgc ttagaaaact tagtaatatc caatggagag
4381 aaattcagtc ctgaagtctg ggatgaaacc tgcaactgta tgttggatat tttcaaaaca
4441 accatcccac atgttttgct gacatggaga cctgtaggaa tggaggaaga ttcatcagaa
4501 aagcatttgg atgtggatct ggaccgccag tctttaagca gcatagataa aaatccctct
4561 gagaggggac agagccagct ctctaaccca acagatgaca gctggaaggg tagaccatac
4621 gcaaatcaga aactgtttgc cagcctcctc atcaagtgtg tggtccagtt ggaattgata
4681 cagaccattg acaacattgt gttctaccct gcgacgagca aaaaggagga tgcagagcac
4741 atggttgccg cccagcaaga cacgctggat gcagatatcc acatagagac ggaggatcag
4801 ggcatgtata agtacatgtc ttcccagcac ctcttcaagc tgttggactg tttgcaggaa
4861 tcccattcat tctcaaaggc cttcaactcc aattacgagc agcggactgt cctgtggcga
4921 gcaggtttta agggcaagtc taaacccaat cttctaaaac aagaaaccag cagcctggcc
4981 tgttgtttga ggatcctgtt tcgaatgtat gttgatgaga accgcaggga ttcctgggaa
5041 gaaatacagc agagactttt aactgtttgc agtgaagctc ttgcctattt catcactgtg
5101 aattctgaga gccatcggga ggcctggaca agtctcttgt tgttacttct aactaaaacc
5161 ctcaaaataa atgatgaaaa gttcaaagca catgcttcaa tgtactaccc ctacttgtgt
5221 gaaattatgc agtttgacct gatccctgag ctccgagcag ttctgcggaa gttcttccta
5281 cggataagtg ttgtgtataa gatatggata ccagaagagc catcacaggt accagcagca
5341 ctgtcaccag tgtggtagcc ctggctgccc aggccagtgc tgcagctctg cagaatgttc
5401 agcatgccat ttctgactgg cacatctcgt gaagtttcat agaaacaagg agttggcatc
5461 ttggatctca gaatggcctg gaaacggatg gcctctacgc tgttccatca cagtctccaa
5521 ctaaggctta tggtatttca ttaaactgtt gcatacccag ttagcacagt aggtggggag
5581 tctgcttcat ttctatcatt ccatttttct gattaaactg tcaaatctgt cattgcatat
5641 gccatcgttt tctagcaaaa tcccatgatt ggctataaac gttttgtaag aagtcactct
5701 ccttgaaaat actgaacata gctgtatagg tttgtgatta ttagagaata tgttaataaa
5761 acttcttgta acggctaact gccacctaaa atatgctggg ttttctgttg tttgagtgtg
5821 ttagagaaat ttgaatgttt ttgtcagtta cgagtcagcc
//