LOCUS AF084481 3688 bp mRNA linear HUM 21-OCT-1998 DEFINITION Homo sapiens transmembrane protein (WFS1) mRNA, complete cds. ACCESSION AF084481 VERSION AF084481.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3688) AUTHORS Inoue,H., Tanizawa,Y., Wasson,J., Behn,P., Kalidas,K., Bernal-Mizrachi,E., Mueckler,M., Marshall,H., Donis-Keller,H., Crock,P., Rogers,D., Mikuni,M., Kumashiro,H., Higashi,K., Sobue,G., Oka,Y. and Permutt,M.A. TITLE A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome) JOURNAL Nat. Genet. 20 (2), 143-148 (1998) PUBMED 9771706 REFERENCE 2 (bases 1 to 3688) AUTHORS Inoue,H., Wasson,J. and Permutt,M.A. TITLE Direct Submission JOURNAL Submitted (18-AUG-1998) Third Dept. of Int. Med., Yamaguchi University, 1144 Kogushi, Ube, Yamaguchi 755, Japan FEATURES Location/Qualifiers source 1..3688 /db_xref="H-InvDB:HIT000066627" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="4" /map="4p16.1" gene 1..3688 /gene="WFS1" CDS 171..2843 /gene="WFS1" /codon_start=1 /product="transmembrane protein" /protein_id="AAC64943.1" /translation="MDSNTAPLGPSCPQPPPAPQPQARSRLNATASLEQERSERPRAP GPQAGPGPGVRDAAAPAEPQAQHTRSRERADGTGPTKGDMEIPFEEVLERAKAGDPKA QTEVGKHYLQLAGDTDEELNSCTAVDWLVLAAKQGRREAVKLLRRCLADRRGITSENE REVRQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVAELLENVGQVNEHDGGAQPGP VPKSLQKQRRMLERLVSSESKNYIALDDFVEITKKYAKGVIPSSLFLQDDEDDDELAG KSPEDLPLRLKVVKYPLHAIMEIKEYLIDMASRAGMHWLSTIIPTHHINALIFFFIIS NLTIDFFAFFIPLVIFYLSFISMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQ AEVNFGWNHLEPYAHFLLSVFFVIFSFPIASKDCIPCSELAVITGFFTVTSYLSLSTH AEPYTRRALATEVTAGLLSLLPSMPLNWPYLKVLGQTFITVPVGHLVVLNVSVPCLLY VYLLYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSVVILLESTGLGLLRASIGYFLF LFALPILVAGLALVGVLQFARWFTSLELTKIAVTVAVCSVPLLLHWWTKASFSVVGMV KSLTRSSMVKLILVWLTAIVLFCWFYVYRSEGMKVYNSTLTWQQYGALCGPRAWKETN MARTQILCSHLEGHRVTWTGRFKYVRVTDIDNSAESAINMLPFFIGDWMRCLYGEAYP ACSPGNTSTAEEELCRLKLLAKHPCHIKKFDRYKFEITVGMPFSSGADGSRSREEDDV TKDIVLRASSEFKSVLLSLRQGSLIEFSTILEGRLGSKWPVFELKAISCLNCMAQLSP TRRHVKIEHDWRSTVHGAVKFAFDFFFFPFLSAA" BASE COUNT 725 a 1175 c 1057 g 731 t ORIGIN 1 gtgcagaagg ccgcgctagc cggctcttca gcagcgagtg cagattgctc ccccgcggcc 61 gcagatctcc cgtttgcgcc gcgttcagct gctcccgaac aacttttctg ccggcccaga 121 ggccccaggg cgtcgcagcg ccgcgtgcgg cccactcacg ggccggcagg atggactcca 181 acactgctcc gctgggcccc tcctgcccac agcccccgcc agcaccgcag ccccaggcgc 241 gttcccgact caatgccaca gcctcgttgg agcaggagag gagcgaaagg ccccgagcac 301 ccggacccca ggctggccct ggccctggtg ttagagacgc agcggccccc gctgaacccc 361 aggcccagca taccaggagc cgggaaagag cagacggcac cgggcctaca aagggagaca 421 tggaaatccc ctttgaagaa gtcctggaga gggccaaggc cggggacccc aaggcacaga 481 ctgaggtggg gaagcactac ctgcagttgg ccggcgacac ggatgaagaa ctcaacagct 541 gcaccgctgt ggactggctg gtcctcgccg cgaagcaggg ccgtcgcgag gctgtgaagc 601 tgcttcgccg gtgcttggcg gacagaagag gcatcacgtc cgagaacgaa cgggaggtga 661 ggcagctctc ctccgagacc gacctggaga gggccgtgcg caaggcagcc ctggtcatgt 721 actggaagct caaccccaag aagaagaagc aggtggccgt ggcggagctg ctggagaatg 781 tcggccaggt caacgagcac gatggagggg cgcagccagg ccccgtgccc aagtccctgc 841 agaagcagag gcggatgctg gagcgcctgg tcagcagcga gtccaagaac tacatcgcgc 901 tggatgactt tgtggagatc actaagaagt acgccaaggg cgtcatcccc agcagcctgt 961 tcctgcagga cgacgaagat gatgacgagc tggcggggaa gagccctgag gacctgccac 1021 tgcgtctgaa ggtggtcaag taccccctgc acgccatcat ggagatcaag gagtacctga 1081 ttgacatggc ctccagggca ggcatgcact ggctgtccac catcatcccc acgcaccaca 1141 tcaacgcgct catcttcttc ttcatcatca gcaacctcac catcgacttc ttcgccttct 1201 tcatcccgct ggtcatcttc tacctgtcct tcatctccat ggtgatctgc accctcaagg 1261 tgttccagga cagcaaggcc tgggagaact tccgcaccct caccgacctg ctgctgcgct 1321 tcgagcccaa cctggatgtg gagcaggccg aggttaactt cggctggaac cacctggagc 1381 cctatgccca tttcctgctc tctgtcttct tcgtcatctt ctccttcccc atcgccagca 1441 aggactgcat cccctgctcg gagctggctg tcatcaccgg cttctttacc gtgaccagct 1501 acctgagcct gagcacccat gcagagccct acacgcgcag ggccctggcc accgaggtca 1561 ccgccggcct gctatcgctg ctgccctcca tgcccttgaa ttggccctac ctgaaggtcc 1621 ttggccagac cttcatcacc gtgcctgtcg gccacctggt cgtcctcaat gtcagcgtcc 1681 cgtgcctgct ctatgtctac ctgctctatc tcttcttccg catggcacag ctgaggaatt 1741 tcaagggcac ctactgctac cttgtgccct acctggtgtg cttcatgtgg tgtgagctct 1801 ccgtggtcat cctgctggag tccaccggcc tggggctgct ccgcgcctcc atcggctact 1861 tcctcttcct ctttgccctc cccatcctgg tggccggcct ggccctggtg ggcgtgctgc 1921 agttcgcccg gtggttcacg tctctggagc tcaccaagat cgcagtcacc gtggcggtct 1981 gtagtgtgcc cctgctgttg cactggtgga ccaaggccag cttctctgtg gtggggatgg 2041 tgaagtccct gacgcggagc tccatggtca agctcatcct ggtgtggctc acggccatcg 2101 tgctgttctg ctggttctat gtgtaccgct cagagggcat gaaggtctac aactccacac 2161 tgacctggca gcagtatggt gcgctgtgcg ggccacgcgc ctggaaggag accaacatgg 2221 cgcgcaccca gatcctctgc agccacctgg agggccacag ggtcacgtgg accggccgct 2281 tcaagtacgt ccgcgtgact gacatcgaca acagcgccga gtctgccatc aacatgctcc 2341 cgttcttcat cggcgactgg atgcgctgcc tctacggcga ggcctaccct gcctgcagcc 2401 ctggcaacac ctccacggcc gaggaggagc tctgtcgcct taagctgctg gccaagcacc 2461 cctgccacat caagaagttc gaccgctaca agtttgagat taccgtgggc atgccattca 2521 gcagcggcgc tgacggctcg cgcagccgcg aggaggacga cgtcaccaag gacatcgtgc 2581 tgcgggccag cagcgagttc aaaagcgtgc tgctcagcct gcgccagggc agcctcatcg 2641 agttcagcac catcctggag ggccgcctgg gcagcaagtg gcctgtcttc gagctcaagg 2701 ccatcagctg cctcaactgc atggcccagc tctcgcccac caggcggcac gtgaagatcg 2761 agcacgactg gcgcagcacc gtgcatggcg ccgtgaagtt cgccttcgac ttctttttct 2821 tcccattcct gtcggcggcc tgaggatggt ccgccacgag gagcttccag tgcatgttgc 2881 catgaggccc ttccccagtg tggccccagc ccgacaggca tgcaccagtg ccgtctgtgc 2941 ccacgtgtgc agactgtggc tgcagagacc ttgcgaccat gtgtagattg catggacccc 3001 gacaaaggga aggctgctgt gtagctctgt ccactctgaa taccaagtgt gttgggaatt 3061 gcatgccatc tccaccctga gcctgacctt tctgagtgac atgggtgtgc caggctagac 3121 taggaggttc cggtgtctgg aaaagcactt tacagatgag attccctctc ctcccccacc 3181 ttcaagcacc ctgttccctc tttctttctt ttgtgttgga tttgtttaaa aaccaaataa 3241 gcatctgtgt aacctccaca gtagcatttc ttatttgttt ggtcactgct acaccttagc 3301 agctcttccc ctttcctggg ggatgtgcac ggcagcttga gcctgtcacg tggtcaaggc 3361 ccggccccat cagaggctgg gggaggcggc acattggcag tgtgtcacac tgagctgggc 3421 accacaggct gcctcatgac cctcctctcc agcaggtagt gggtgaatgt gtgaaggtct 3481 tgcctgaatc catcaggact tgggaaacag agaaccctgt gggggtggct gtgggggagg 3541 tccctgccag tgtttagaag agcctgactg tgttcagtgc cttggagcag aaagccaggg 3601 tcctgagtgg ctgaaataaa agcctctggt ggaacctgca aaaaaaaaaa aaaaaaaaaa 3661 aaaaaaaaga aaaaagaaaa agaaataa //