LOCUS       AF084481                3688 bp    mRNA    linear   HUM 21-OCT-1998
DEFINITION  Homo sapiens transmembrane protein (WFS1) mRNA, complete cds.
ACCESSION   AF084481
VERSION     AF084481.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3688)
  AUTHORS   Inoue,H., Tanizawa,Y., Wasson,J., Behn,P., Kalidas,K.,
            Bernal-Mizrachi,E., Mueckler,M., Marshall,H., Donis-Keller,H.,
            Crock,P., Rogers,D., Mikuni,M., Kumashiro,H., Higashi,K., Sobue,G.,
            Oka,Y. and Permutt,M.A.
  TITLE     A gene encoding a transmembrane protein is mutated in patients with
            diabetes mellitus and optic atrophy (Wolfram syndrome)
  JOURNAL   Nat. Genet. 20 (2), 143-148 (1998)
   PUBMED   9771706
REFERENCE   2  (bases 1 to 3688)
  AUTHORS   Inoue,H., Wasson,J. and Permutt,M.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-AUG-1998) Third Dept. of Int. Med., Yamaguchi
            University, 1144 Kogushi, Ube, Yamaguchi 755, Japan
FEATURES             Location/Qualifiers
     source          1..3688
                     /db_xref="H-InvDB:HIT000066627"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..3688
                     /gene="WFS1"
     CDS             171..2843
                     /gene="WFS1"
                     /codon_start=1
                     /product="transmembrane protein"
                     /protein_id="AAC64943.1"
                     /db_xref="GI:3777583"
                     /translation="MDSNTAPLGPSCPQPPPAPQPQARSRLNATASLEQERSERPRAP
                     GPQAGPGPGVRDAAAPAEPQAQHTRSRERADGTGPTKGDMEIPFEEVLERAKAGDPKA
                     QTEVGKHYLQLAGDTDEELNSCTAVDWLVLAAKQGRREAVKLLRRCLADRRGITSENE
                     REVRQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVAELLENVGQVNEHDGGAQPGP
                     VPKSLQKQRRMLERLVSSESKNYIALDDFVEITKKYAKGVIPSSLFLQDDEDDDELAG
                     KSPEDLPLRLKVVKYPLHAIMEIKEYLIDMASRAGMHWLSTIIPTHHINALIFFFIIS
                     NLTIDFFAFFIPLVIFYLSFISMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQ
                     AEVNFGWNHLEPYAHFLLSVFFVIFSFPIASKDCIPCSELAVITGFFTVTSYLSLSTH
                     AEPYTRRALATEVTAGLLSLLPSMPLNWPYLKVLGQTFITVPVGHLVVLNVSVPCLLY
                     VYLLYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSVVILLESTGLGLLRASIGYFLF
                     LFALPILVAGLALVGVLQFARWFTSLELTKIAVTVAVCSVPLLLHWWTKASFSVVGMV
                     KSLTRSSMVKLILVWLTAIVLFCWFYVYRSEGMKVYNSTLTWQQYGALCGPRAWKETN
                     MARTQILCSHLEGHRVTWTGRFKYVRVTDIDNSAESAINMLPFFIGDWMRCLYGEAYP
                     ACSPGNTSTAEEELCRLKLLAKHPCHIKKFDRYKFEITVGMPFSSGADGSRSREEDDV
                     TKDIVLRASSEFKSVLLSLRQGSLIEFSTILEGRLGSKWPVFELKAISCLNCMAQLSP
                     TRRHVKIEHDWRSTVHGAVKFAFDFFFFPFLSAA"
BASE COUNT          725 a         1175 c         1057 g          731 t
ORIGIN      
        1 gtgcagaagg ccgcgctagc cggctcttca gcagcgagtg cagattgctc ccccgcggcc
       61 gcagatctcc cgtttgcgcc gcgttcagct gctcccgaac aacttttctg ccggcccaga
      121 ggccccaggg cgtcgcagcg ccgcgtgcgg cccactcacg ggccggcagg atggactcca
      181 acactgctcc gctgggcccc tcctgcccac agcccccgcc agcaccgcag ccccaggcgc
      241 gttcccgact caatgccaca gcctcgttgg agcaggagag gagcgaaagg ccccgagcac
      301 ccggacccca ggctggccct ggccctggtg ttagagacgc agcggccccc gctgaacccc
      361 aggcccagca taccaggagc cgggaaagag cagacggcac cgggcctaca aagggagaca
      421 tggaaatccc ctttgaagaa gtcctggaga gggccaaggc cggggacccc aaggcacaga
      481 ctgaggtggg gaagcactac ctgcagttgg ccggcgacac ggatgaagaa ctcaacagct
      541 gcaccgctgt ggactggctg gtcctcgccg cgaagcaggg ccgtcgcgag gctgtgaagc
      601 tgcttcgccg gtgcttggcg gacagaagag gcatcacgtc cgagaacgaa cgggaggtga
      661 ggcagctctc ctccgagacc gacctggaga gggccgtgcg caaggcagcc ctggtcatgt
      721 actggaagct caaccccaag aagaagaagc aggtggccgt ggcggagctg ctggagaatg
      781 tcggccaggt caacgagcac gatggagggg cgcagccagg ccccgtgccc aagtccctgc
      841 agaagcagag gcggatgctg gagcgcctgg tcagcagcga gtccaagaac tacatcgcgc
      901 tggatgactt tgtggagatc actaagaagt acgccaaggg cgtcatcccc agcagcctgt
      961 tcctgcagga cgacgaagat gatgacgagc tggcggggaa gagccctgag gacctgccac
     1021 tgcgtctgaa ggtggtcaag taccccctgc acgccatcat ggagatcaag gagtacctga
     1081 ttgacatggc ctccagggca ggcatgcact ggctgtccac catcatcccc acgcaccaca
     1141 tcaacgcgct catcttcttc ttcatcatca gcaacctcac catcgacttc ttcgccttct
     1201 tcatcccgct ggtcatcttc tacctgtcct tcatctccat ggtgatctgc accctcaagg
     1261 tgttccagga cagcaaggcc tgggagaact tccgcaccct caccgacctg ctgctgcgct
     1321 tcgagcccaa cctggatgtg gagcaggccg aggttaactt cggctggaac cacctggagc
     1381 cctatgccca tttcctgctc tctgtcttct tcgtcatctt ctccttcccc atcgccagca
     1441 aggactgcat cccctgctcg gagctggctg tcatcaccgg cttctttacc gtgaccagct
     1501 acctgagcct gagcacccat gcagagccct acacgcgcag ggccctggcc accgaggtca
     1561 ccgccggcct gctatcgctg ctgccctcca tgcccttgaa ttggccctac ctgaaggtcc
     1621 ttggccagac cttcatcacc gtgcctgtcg gccacctggt cgtcctcaat gtcagcgtcc
     1681 cgtgcctgct ctatgtctac ctgctctatc tcttcttccg catggcacag ctgaggaatt
     1741 tcaagggcac ctactgctac cttgtgccct acctggtgtg cttcatgtgg tgtgagctct
     1801 ccgtggtcat cctgctggag tccaccggcc tggggctgct ccgcgcctcc atcggctact
     1861 tcctcttcct ctttgccctc cccatcctgg tggccggcct ggccctggtg ggcgtgctgc
     1921 agttcgcccg gtggttcacg tctctggagc tcaccaagat cgcagtcacc gtggcggtct
     1981 gtagtgtgcc cctgctgttg cactggtgga ccaaggccag cttctctgtg gtggggatgg
     2041 tgaagtccct gacgcggagc tccatggtca agctcatcct ggtgtggctc acggccatcg
     2101 tgctgttctg ctggttctat gtgtaccgct cagagggcat gaaggtctac aactccacac
     2161 tgacctggca gcagtatggt gcgctgtgcg ggccacgcgc ctggaaggag accaacatgg
     2221 cgcgcaccca gatcctctgc agccacctgg agggccacag ggtcacgtgg accggccgct
     2281 tcaagtacgt ccgcgtgact gacatcgaca acagcgccga gtctgccatc aacatgctcc
     2341 cgttcttcat cggcgactgg atgcgctgcc tctacggcga ggcctaccct gcctgcagcc
     2401 ctggcaacac ctccacggcc gaggaggagc tctgtcgcct taagctgctg gccaagcacc
     2461 cctgccacat caagaagttc gaccgctaca agtttgagat taccgtgggc atgccattca
     2521 gcagcggcgc tgacggctcg cgcagccgcg aggaggacga cgtcaccaag gacatcgtgc
     2581 tgcgggccag cagcgagttc aaaagcgtgc tgctcagcct gcgccagggc agcctcatcg
     2641 agttcagcac catcctggag ggccgcctgg gcagcaagtg gcctgtcttc gagctcaagg
     2701 ccatcagctg cctcaactgc atggcccagc tctcgcccac caggcggcac gtgaagatcg
     2761 agcacgactg gcgcagcacc gtgcatggcg ccgtgaagtt cgccttcgac ttctttttct
     2821 tcccattcct gtcggcggcc tgaggatggt ccgccacgag gagcttccag tgcatgttgc
     2881 catgaggccc ttccccagtg tggccccagc ccgacaggca tgcaccagtg ccgtctgtgc
     2941 ccacgtgtgc agactgtggc tgcagagacc ttgcgaccat gtgtagattg catggacccc
     3001 gacaaaggga aggctgctgt gtagctctgt ccactctgaa taccaagtgt gttgggaatt
     3061 gcatgccatc tccaccctga gcctgacctt tctgagtgac atgggtgtgc caggctagac
     3121 taggaggttc cggtgtctgg aaaagcactt tacagatgag attccctctc ctcccccacc
     3181 ttcaagcacc ctgttccctc tttctttctt ttgtgttgga tttgtttaaa aaccaaataa
     3241 gcatctgtgt aacctccaca gtagcatttc ttatttgttt ggtcactgct acaccttagc
     3301 agctcttccc ctttcctggg ggatgtgcac ggcagcttga gcctgtcacg tggtcaaggc
     3361 ccggccccat cagaggctgg gggaggcggc acattggcag tgtgtcacac tgagctgggc
     3421 accacaggct gcctcatgac cctcctctcc agcaggtagt gggtgaatgt gtgaaggtct
     3481 tgcctgaatc catcaggact tgggaaacag agaaccctgt gggggtggct gtgggggagg
     3541 tccctgccag tgtttagaag agcctgactg tgttcagtgc cttggagcag aaagccaggg
     3601 tcctgagtgg ctgaaataaa agcctctggt ggaacctgca aaaaaaaaaa aaaaaaaaaa
     3661 aaaaaaaaga aaaaagaaaa agaaataa
//