LOCUS AF082283 2810 bp mRNA linear HUM 11-MAY-1999
DEFINITION Homo sapiens CARD-containing apoptotic signaling protein (BCL10)
mRNA, complete cds.
ACCESSION AF082283
VERSION AF082283.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2810)
AUTHORS Zhang,Q., Siebert,R., Yan,M., Hinzmann,B., Cui,X., Xue,L.,
Rakestraw,K.M., Naeve,C.W., Beckmann,G., Weisenburger,D.D.,
Sanger,W.G., Nowotny,H., Vesely,M., Callet-Bauchu,E., Salles,G.,
Dixit,V.M., Rosenthal,A., Schlegelberger,B. and Morris,S.W.
TITLE Inactivating mutations and overexpression of BCL10, a caspase
recruitment domain-containing gene, in MALT lymphoma with
t(1;14)(p22;q32)
JOURNAL Nat. Genet. 22 (1), 63-68 (1999)
PUBMED 10319863
REFERENCE 2 (bases 1 to 2810)
AUTHORS Morris,S.W., Cui,X., Zhang,Q., Rakestraw,K. and Naeve,C.
TITLE Direct Submission
JOURNAL Submitted (04-AUG-1998) Experimental Oncology, St. Jude Children's
Research Hospital, 332 N. Lauderdale Ave., Memphis, TN 38105, USA
FEATURES Location/Qualifiers
source 1..2810
/db_xref="H-InvDB:HIT000066514"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p22"
/tissue_type="spleen"
gene 1..2810
/gene="BCL10"
CDS 707..1408
/gene="BCL10"
/note="B-cell CLL/lymphoma 10; similar to equine
herpesvirus-2 ORF E10; overexpressed due to juxtaposition
to the IgH enhancer in the t(1;14)(p22;q32) in MALT
lymphomas; wild-type BCL10 gene promotes apoptotic cell
death and induces NF-kappaB activation; a variety of
mutations that inactivate the pro-apoptotic function of
the gene, but in many cases leave NF-kappaB activation
intact, occur in MALT lymphomas and other tumors of
various types"
/codon_start=1
/product="CARD-containing apoptotic signaling protein"
/protein_id="AAC99767.1"
/translation="MEPTAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAK
KILSREDTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDE
VLKLRNIKLEHLKGLKCSSCEPFPDGATNNLSRSNSDESNFSEKLRASTVMYHPEGES
STTPFFSTNSSLNLPVLEVGRTENTIFSSTTLPRPGDPGAPPLPPDLQLEEEGTCANS
SEMFLPLRSRTVSRQ"
BASE COUNT 768 a 627 c 551 g 864 t
ORIGIN
1 tttttttttt ttttttgctt tcccgtttct taaacattgg cgttcccaag tttctccttg
61 gtcctcctgt catttttatc tactctcgta gcttcaaata ccatctagtt tatagtttat
121 ttagcatgtt gtccaagcca ccgtcttggg cccagggctc tacctgtagc ttttcatcca
181 cacttctcag gttgcttctt acacagcgcc atagtagtta aaatacggtc tggggatagt
241 cgtctcttca tcagtctccc ccgacgacct gcgcaggcgt ggcttgagga aacgcccgct
301 gtgggcggag ccacccgaaa ggctccggtc gggggcggga acaggatcgg cccgcgggct
361 ggcgtcgata ggctgccgca gagacagggc gggctctgct aagggacgcg cctcgccgtg
421 gggcggtgcc tgcgcctgag cctctacgag agggaaggaa cgctgctccg agctccgcgt
481 cgcgtcgcgt agattcgcgt cgccgtcgac ctcagaggcg gggccggaag cgctacggtt
541 tgacccccga gtccctctgt tcccgaaggg gcggccgtct ttctgccgac ccgctccgcc
601 tcctctcctt cttccccatt acccggaggc cgaagccccc agccagggcg gggcggcgca
661 gcccgagctc ccggacccgg aagaagcgcc atctcccgcc tccaccatgg agcccaccgc
721 accgtccctc accgaggagg acctcactga agtgaagaag gacgccttag aaaatttacg
781 tgtatacctg tgtgagaaaa tcatagctga gagacatttt gatcatctac gtgcaaaaaa
841 aatactcagt agagaagaca ctgaagaaat ttcttgtcga acatcaagta gaaaaagggc
901 tggaaaattg ttagactact tacaggaaaa cccaaaaggt ctggacaccc ttgttgaatc
961 tattcggcga gaaaaaacac agaacttcct gatacagaag attacagatg aagtgctgaa
1021 acttagaaat ataaaactag aacatctgaa aggactaaaa tgtagcagtt gtgaaccttt
1081 tccagatgga gccacgaaca acctctccag atcaaattca gatgagagta atttctctga
1141 aaaactgagg gcatccactg tcatgtacca tccagaagga gaatccagca cgacgccctt
1201 tttttctact aattcttctc tgaatttgcc tgttctagaa gtaggcagaa ctgaaaatac
1261 catcttctct tcaactacac ttcccagacc tggggaccca ggggctcctc ctttgccacc
1321 agatctacag ttagaagaag aaggaacttg tgcaaactct agtgagatgt ttcttccctt
1381 aagatcacgt actgtttcac gacaatgaca ctttattgcc ttttaatttt taatgatgac
1441 aaaaaatgtt ttaaagaata tgacttttta taaaatggct gtaatcattt gtttacattt
1501 gatgcatgtc ttttaaaatg caatgtaagc atactttgta aataggattt ttagaattaa
1561 aaaagcatac ttctaggata gctaactgta aatcatgttg atcatgtact ttttagtaat
1621 ttcttttttt cctttttaag gtctttcagt acttttttaa atattttcta ttttaagact
1681 gattttaata gggaatatat ctctatttga gaatagaccc ttactaggaa gaacgttttt
1741 tcctcagtgc atttgtgcta gaaattttca agagtctaat agtctttgcc agtcattcag
1801 cagcaaattt tcagcattaa gctgttcctg ttcagtaata aaaccggtca ctgatgggaa
1861 aactgccaat atagaaaaat aaaaatctct tttccactcc attgtcgtat aggcatgtaa
1921 acagcctctt tttgatactg gaggaacact tgatggagtg tgagccacct aagatctcgg
1981 tttgccaaaa ttcatttcta attaacctta ctaattatac tactttgtta ggattttcac
2041 attcttggct taatcatttt cattcctaaa gaaaaatatc ttggcctaaa cctcagttat
2101 tacatgtaat ttgatgaggt attttttcct tttttctttt tttttttttt gagacagtct
2161 tgctctatcg cccaggctgg agtgcagtgg cgcattctag gctcactgca acttctgcct
2221 cccatgctta cgtgatcctc tcacctcagc ctctcaagta atatagctga gactacaagt
2281 gtgtgccacc atgcctcact aatttttgta ttatttttgt agagacggtg ttttgccatg
2341 ttggccaggc tggtcttgaa ctcctggact caagcaacct acccagcgtg gcctcccaaa
2401 gtgctgggat tacagacacg agccacctca cctagcctga tgagattttt aaaaaatatt
2461 ttctctgtac ttttcattct cttttaatga ggaccaatgt acagttgaaa taactggaac
2521 aaattatttt tggtgtgtgt gacaattctg tttttaatgc tatttgaaca agtgggccat
2581 tagccagatt tgtctttttg ttgtaaaaca aaatttgact aattttacat gtttataaat
2641 cttatgctct cactgtttgt ttttatttaa attacaattt tatctgtttc ctgacattgt
2701 ctcctatata tttctattat taattgcaaa aacatagaaa tggaaatttt gctatcaaca
2761 ataaaatttt tttaaaataa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//