LOCUS AF077188 3643 bp mRNA linear HUM 22-JUL-1999
DEFINITION Homo sapiens cullin 4A (CUL4A) mRNA, complete cds.
ACCESSION AF077188
VERSION AF077188.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3643)
AUTHORS Chen,L.C., Manjeshwar,S., Lu,Y., Moore,D., Ljung,B.M., Kuo,W.L.,
Dairkee,S.H., Wernick,M., Collins,C. and Smith,H.S.
TITLE The human homologue for the Caenorhabditis elegans cul-4 gene is
amplified and overexpressed in primary breast cancers
JOURNAL Cancer Res. 58 (16), 3677-3683 (1998)
PUBMED 9721878
REFERENCE 2 (bases 1 to 3643)
AUTHORS Chen,L.-C. and Smith,H.S.
TITLE Direct Submission
JOURNAL Submitted (07-JUL-1998) Geraldine Brush Cancer Research Institute,
CPMCRI, 2330 Clay Street, San Francisco, CA 94115, USA
FEATURES Location/Qualifiers
source 1..3643
/db_xref="H-InvDB:HIT000066215"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="13"
/map="13q34"
/cell_line="breast cancer cell line, BT474"
gene 1..3643
/gene="CUL4A"
CDS 161..2140
/gene="CUL4A"
/note="cul-4A"
/codon_start=1
/product="cullin 4A"
/protein_id="AAD45191.1"
/translation="MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCR
QMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIER
ERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYL
NHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPD
LAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVI
EVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLD
KIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLE
GMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKL
QEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGF
SFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFR
IKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLK
FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA"
BASE COUNT 1062 a 687 c 876 g 1017 t
ORIGIN
1 gtcttctcag ccgggacgcc agcggttctg attacagacc tcggctgccc gacaactaca
61 cgcaggacac gtggcggaag ctgcacgagg cggtgcgggc cgtgcagagc agcacctcca
121 tcaggctgtg gaaaatctct gttctcacaa agtctcccca atgctctaca agcaactgcg
181 tcaggcctgt gaagaccacg tccaggcaca gatccttccg tttagagaag actcactaga
241 tagtgtttta tttttaaaga agattaacac gtgctggcag gaccactgca gacaaatgat
301 catgatcaga agcatcttcc tgttcttgga ccgcacctat gtgctgcaga actccacgct
361 gccctccatc tgggatatgg gattagaact gtttagaacc catattatta gtgataaaat
421 ggttcagagt aaaaccattg atggaatcct actgctgatc gagcgcgaga ggagcggcga
481 ggccgtggac cggagcctgt tgcggagcct cctgggcatg ctgtctgacc tgcaggtgta
541 taaagattca tttgaactga aatttttgga agagactaat tgcttatatg ctgccgaagg
601 ccaaaggtta atgcaggaaa gagaggttcc agaatatctt aaccatgtaa gtaaacgctt
661 agaggaagag ggagacagag taatcactta cttggaccac agcacacaga aaccactgat
721 tgcttgtgtg gagaaacagc tattaggaga acatttaaca gcaattctgc agaaagggct
781 cgaccactta ctggatgaga acagagtgcc ggacctcgca cagatgtacc agctgttcag
841 ccgggtgagg ggcgggcagc aggcgctgct gcagcactgg agcgagtaca tcaagacttt
901 tggaacagcg atcgtaatca atcctgagaa agacaaagac atggtccaag acctgttgga
961 cttcaaggac aaggtggacc acgtgatcga ggtctgcttc cagaagaatg agcggttcgt
1021 caacctgatg aaggagtcct ttgagacgtt catcaacaag agacccaaca agcctgcaga
1081 actgatcgca aagcatgtgg attcaaagtt aagagcaggc aacaaagaag ccacagacga
1141 ggagctggag cggacgttgg acaagatcat gatcctgttc aggtttatcc acggtaaaga
1201 tgtctttgaa gcattttata aaaaagattt ggcaaaaaga ctccttgttg ggaaaagtgc
1261 ctcagtcgat gctgaaaagt ctatgttgtc aaagctcaag catgagtgcg gtgcagcctt
1321 caccagcaag ctggaaggca tgttcaagga catggagctt tcgaaggaca tcatggttca
1381 tttcaagcag catatgcaga atcagagtga ctcaggccct atagacctca cagtgaacat
1441 actcacaatg ggctactggc caacatacac gcccatggaa gtgcacttaa ccccagaaat
1501 gattaaactt caggaagtat ttaaggcatt ttatcttgga aagcacagtg gtcgaaaact
1561 tcagtggcaa actactttgg gacatgctgt tttaaaagcg gagtttaaag aagggaagaa
1621 ggaattccag gtgtccctct tccagacact ggtgctcctc atgttcaacg agggagatgg
1681 cttcagcttt gaggagataa aaatggccac ggggatagag gatagtgaat tgcgcagaac
1741 gctgcagtcc ctggcctgtg gcaaagcacg tgtgctgatt aaaagtccca aaggaaagga
1801 agtggaagat ggagacaagt tcatttttaa tggagagttc aagcacaagt tgtttagaat
1861 aaagatcaat caaattcaga tgaaggaaac tgttgaggaa caggttagca ccactgagag
1921 agtgtttcag gatagacaat atcagattga tgctgctatc gtcagaataa tgaagatgag
1981 aaagactctt ggtcataatc ttctagtttc tgaattatat aatcagctga aatttccagt
2041 aaagcctgga gatttgaaaa agagaattga atctctgata gacagagact atatggagag
2101 agacaaagac aatccgaatc agtaccacta cgtggcctga cgcatctgca gacggttccc
2161 cttcatgaaa cactagaatg taccctcaga gcaggaagca cacctgtgcc atttctggga
2221 ctctgattga tccagctgtg gacattggaa ggcgaaggaa gggaggtggc tcctgggtca
2281 tctttcacaa ggctcaagac ttcaacctgc agatgtatct ttttccctcc agtttttcct
2341 ctagttcttt taggcattta aattgtttct gttactctgt gcaaaataac tttgagattg
2401 gacaagaaga tgttactaaa gagaagttcc tttaaaaggt cttgttcttg tgtcaaaaag
2461 ctgcaagttt ggtttgttct cgtgtgtgat catgagtgca caatgaagaa gaccctagat
2521 gctgcatttt ttagctctga agattcctta ggtatccctg aagacagctc gctcagatga
2581 tcagcattta gagtgaaaac aagggccctt catgggtgaa cattagaaag agccagggtt
2641 caaagctggc gaatggatga cgcaccctag ccactggccc ctccctgttt catgtatttc
2701 caaaagttgt aaactttggt ggctgatttt tcgtaagtca ggtttctaag tgagctccct
2761 gaggtgccaa ggccatggtg tccgccctgc tgcgtctgtt cgtcagctga gttccttgtg
2821 aatctctgtt ttaggggttg gggctagtgt gtttgtgttt ccattctaag attgagtctg
2881 gcagtccctg tttttttgca ttggggtaac tgctctttga ttttttttaa ttgcagtatt
2941 tgtgtgattg caataataaa gtttggtttg gtttttacag tcatgcgcag ggacgatcct
3001 tgttctctgc tgtaaactgt aaaaagttta tggagaccta aagtcttgat gttgtgaagc
3061 agaggttatt ttgtggaaag attaaaagga ttttgttggt acctggtttt gtgttgtgta
3121 tatatacatg aggttgaaca gtgaaaggaa agttcagtag tgatgttaga agggtaacta
3181 tgacaaagat acttttgaga taacatttaa aagtacttta tattttacat aatagcatgt
3241 ttcattttga ttaaaagcta ccaaaggaat tttgatcatg gcataagtgt ttaaagcaat
3301 attttctgga atataccaag tttatataat ttgattttgt gctaaattat taagagtctc
3361 tttttgaaac atgcgggttt gaaatatgac accttgtggg tttccatatt aaaatcctca
3421 ctctttaatt gtcattttta tctttgaaaa ttttcattta tgagttccat gatatgtggt
3481 ctaagaaaga ccaaacagat ttctattttt ttttcttata agttcgttgt gtctanagat
3541 tgttaatatt gtaatttaat gtagacttac tttgaataaa attagtttaa ttggccttaa
3601 aattacatta ataaaacttt gtgatatgca aatgacacat tca
//