LOCUS       AF056490                3396 bp    mRNA    linear   HUM 04-JUN-1998
DEFINITION  Homo sapiens cAMP-specific phosphodiesterase 8A (PDE8A) mRNA,
            partial cds.
ACCESSION   AF056490
VERSION     AF056490.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3396)
  AUTHORS   Fisher,D.A., Smith,J.F., Pillar,J.S., St Denis,S.H. and Cheng,J.B.
  TITLE     Isolation and characterization of PDE8A, a novel human
            cAMP-specific phosphodiesterase
  JOURNAL   Biochem. Biophys. Res. Commun. 246 (3), 570-577 (1998)
   PUBMED   9618252
REFERENCE   2  (bases 1 to 3396)
  AUTHORS   Fisher,D.A., Smith,J.F., Pillar,J.S., St Denis,S.H. and Cheng,J.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-1998) Molecular Sciences, Pfizer Central
            Research, Groton, CT 06340, USA
FEATURES             Location/Qualifiers
     source          1..3396
                     /db_xref="H-InvDB:HIT000064731"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     gene            <1..3396
                     /gene="PDE8A"
     CDS             <1..2142
                     /gene="PDE8A"
                     /note="PDE8A1"
                     /codon_start=1
                     /product="cAMP-specific phosphodiesterase 8A"
                     /protein_id="AAC39763.1"
                     /db_xref="GI:3184389"
                     /translation="LACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVG
                     VVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVF
                     TALENSEDAIEITSEDRFIQYANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTI
                     NSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEK
                     ISECVQSDTRTDNQTGKHKDRRKGSLDVKAVASRATEVSSQRRHSSMARIHSMTIEAP
                     ITKVINVINAAQESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMS
                     DGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAA
                     THNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLH
                     ATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAV
                     LESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVN
                     SINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEW
                     AARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVD
                     LPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE"
BASE COUNT         1079 a          717 c          681 g          919 t
ORIGIN      
        1 cttgcctgtt tcctggacaa acatcatgac attatcatca tagaccacag aaatcctcga
       61 cagctggatg cagaggcact gtgcaggtct atcagatcat caaaactctc agaaaacaca
      121 gttattgttg gtgtagtacg cagggtggat agagaagagt tgtccgtaat gcctttcatt
      181 tctgctggat ttacaaggag gtatgtagaa aaccccaaca tcatggcctg ctacaatgaa
      241 ctgctccagc tggagtttgg agaggtgcga tcacaactga aactcagggc ttgtaactca
      301 gtattcactg cattagaaaa cagtgaagat gcaattgaaa ttacaagcga agaccgtttt
      361 atacagtatg caaatcctgc atttgaaaca acaatgggct atcagtcagg tgaattaata
      421 gggaaggagt taggagaagt gcctataaat gaaaaaaagg ctgacttgct cgatactata
      481 aattcatgca tcaggatagg caaggagtgg caaggaattt actatgccaa aaagaaaaac
      541 ggagataata tacaacaaaa tgtgaagata atacctgtca ttggacaggg aggaaaaatt
      601 agacactatg tgtccattat cagagtgtgc aatggcaaca ataaggctga gaaaatatcc
      661 gaatgtgttc agtctgacac tcgtacagat aatcagacag gcaaacataa agacaggaga
      721 aaaggctcac tagacgtcaa agctgttgcc tcccgtgcaa ctgaagtttc cagccagaga
      781 cgacactctt ccatggcccg gatacattcc atgacaattg aggcgcccat caccaaggta
      841 atcaatgtta tcaatgctgc ccaggaaagt agtcccatgc ctgtgacaga agccctagac
      901 cgtgtgctgg aaattctaag aaccactgag ttatattcac cacagtttgg tgctaaagat
      961 gatgatcccc atgccaatga ccttgttggg ggcttaatgt ctgatggttt gcgaagacta
     1021 tcagggaatg aatatgttct ttcaacaaaa aacactcaaa tggtttcaag caatataatc
     1081 actcccatct cccttgatga tgtcccacca cggatagctc gggccatgga aaatgaggaa
     1141 tactgggact ttgatatttt tgaactggag gctgccaccc acaataggcc tttgatttat
     1201 cttggtctca aaatgtttgc tcgctttgga atctgtgaat tcttacactg ctccgagtca
     1261 acgctaagat catggttaca aattatcgaa gccaattatc attcctccaa tccctaccac
     1321 aattctacac attctgctga tgtgcttcat gccactgcct attttctctc caaggagagg
     1381 ataaaggaaa ctttagatcc aattgatgag gtcgctgcac tcatcgcagc caccattcat
     1441 gatgtggatc accctgggag aaccaactcc ttcctgtgta atgctggaag tgagctggcc
     1501 attttgtaca atgacactgc tgtgctggag agccaccatg cggccttggc cttccagctg
     1561 accactggag atgataaatg caatatattt aaaaacatgg agaggaatga ttatcggaca
     1621 ctgcgccagg ggattatcga catggtctta gccacagaaa tgacaaagca ctttgagcat
     1681 gtcaacaaat ttgtcaacag catcaacaaa cccttggcaa cactagaaga aaatggggaa
     1741 actgataaaa accaggaagt gataaacact atgcttagga ctccagagaa ccggacccta
     1801 atcaaacgaa tgctgattaa atgtgctgat gtgtccaatc cctgccgacc cctgcagtac
     1861 tgcatcgagt gggctgcacg catttcggaa gaatattttt ctcagactga tgaagagaag
     1921 cagcagggct tacctgtggt gatgccagtg tttgacagaa atacctgcag catccccaaa
     1981 tcccaaatct ctttcattga ttacttcatc acagacatgt ttgatgcttg ggatgccttt
     2041 gtagacctgc ctgatttaat gcagcatctt gacaacaact ttaaatactg gaaaggactg
     2101 gacgaaatga agctgcggaa cctccgacca cctcctgaat agtgggagac accacccaga
     2161 gccctgaagc tttgttcctt cggtcatttg gaattcctga gggcagccag agctccttgg
     2221 tcctttcagt actaggcaga acagcccccg atctgcatag cctgtgaaag cccacgggga
     2281 catcagtaac cttctgcagc caccatccaa tgccattact gtcaagtgag acttggccac
     2341 tgtagcctgg gcctgctgca ggagctcttc agaaaggcac atgaggacca cggtttgcct
     2401 cagtttctgg taaaacacaa ggtctggagt gcccctgcaa agggtattga tggacttcct
     2461 gccagtgaca gagcatgtct attgcaaaca attctctcag ttacgttcag cacttaagaa
     2521 cggctaatgg caataggatc tttagcaact ttttcacatc atagaaggtg caatcgctca
     2581 cttgggaaca ctactgagag tgacttctct tttaaaattg agtagcagat gaaaaattaa
     2641 aatttgaact tgattattaa tatcaattaa aatgttttat ttattttatt aaaagctcaa
     2701 tattttctat gaattcaaaa atacttcaga gccaaagcca acttcaaata ccgtgaccaa
     2761 atttacatga ttcatattca ttatgcatta cttggtatac agacttattt tcataatgca
     2821 aattaataaa atgacacttt tactgcacta tagaaatatt catgtatgtt aaacttttct
     2881 gattgaggct aactggaaaa agctggggtc gtattctaag tgctaaagaa ggctgcttct
     2941 actgtataga acccagggct ctgaaacagc tctagccgcc taatgcactt cacaggtaac
     3001 tccccaaggt aaaactagac tctcttgttg gttcgcaaag aaaagttagg acttaacact
     3061 tttttctaaa attttataat tcaatttcca aaagtctact ctattttata ctgtttctac
     3121 aaaatattcc ttataaaaac aaagaacaaa aattgaatat ttaatgaatt gacattttat
     3181 aaccaacctg tttttatcta cggtgggaat ctttgatgcc agaaatttat aaagaggttc
     3241 tgtatcttca caccttgaat aagcataata ccataaaaaa tgacacttga catgtcaatg
     3301 tatttgtcat ttcattttaa actcgtattt gtggtttttt tcccagataa aaatgaaatt
     3361 aaaccatttc tttttaagaa aaaaaaaaaa aaaaaa
//