LOCUS       HUMPDX2                  828 bp    DNA     linear   HUM 26-SEP-2002
DEFINITION  Homo sapiens insulin promoter factor 1 (PDX1) gene, exon 2 and
            complete cds.
ACCESSION   AF035260
VERSION     AF035260.1
KEYWORDS    .
SEGMENT     2 of 2
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 828)
  AUTHORS   Hara,M., Lindner,T.H., Paz,V.P., Wang,X., Iwasaki,N. and Bell,G.I.
  TITLE     Mutations in the pancreatic and duodenal homeobox gene (PDX1) are
            not a common cause of MODY/Early-onset Type 2 diabetes in Japanese
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 828)
  AUTHORS   Hara,M., Lindner,T.H., Paz,V.P., Wang,X., Iwasaki,N. and Bell,G.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-NOV-1997) Biochemistry, Molecular Biology, and
            Medicine, The University of Chicago, Howard Hughes Medical
            Institute, 5841 South Maryland Avenue, MC1028, Chicago, IL 60637,
            USA
FEATURES             Location/Qualifiers
     source          1..828
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.1"
                     /clone_lib="PAC library, Genome Systems Inc."
     gene            order(AF035259.1:<283..992,1..828)
                     /gene="PDX1"
                     /note="pancreatic and duodenal homeobox gene"
     mRNA            join(AF035259.1:<283..688,234..828)
                     /gene="PDX1"
                     /product="insulin promoter factor 1"
     CDS             join(AF035259.1:283..688,234..679)
                     /gene="PDX1"
                     /note="IPF1; transcription factor"
                     /codon_start=1
                     /product="insulin promoter factor 1"
                     /protein_id="AAB88463.1"
                     /db_xref="GI:2665701"
                     /translation="MNGEEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPP
                     PPPHPFPGALGALEQGSPPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPFPE
                     GAEPGVLEEPNRVQLPFPWMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQLLE
                     LEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGG
                     GVAEPEQDCAVTSGEELLALPPPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAP
                     RRPQEPR"
     intron          <1..233
                     /gene="PDX1"
                     /note="size=3.8 kb"
                     /number=1
     exon            234..828
                     /gene="PDX1"
                     /number=2
BASE COUNT          149 a          250 c          305 g          124 t
ORIGIN      
        1 tcgagtttgg tctccaataa aaaggctatc tttattagga agggcttgag ttactaggga
       61 agagcttcgc gcgcctacac taggcgctga aatgggatgc tggggcttgg tggctccggc
      121 gggagcagct ggtagggcta gggctccctg gccccccttg aaggggttgg gctgcgtggg
      181 tgggggctgt gcggggctcc gggggccaca ctcacgccct gtgtcgcccg caggcggcgc
      241 ctacgctgcg gagccggagg agaacaagcg gacgcgcacg gcctacacgc gcgcacagct
      301 gctagagctg gagaaggagt tcctattcaa caagtacatc tcacggccgc gccgggtgga
      361 gctggctgtc atgttgaact tgaccgagag acacatcaag atctggttcc aaaaccgccg
      421 catgaagtgg aaaaaggagg aggacaagaa gcgcggcggc gggacagctg tcgggggtgg
      481 cggggtcgcg gagcctgagc aggactgcgc cgtgacctcc ggcgaggagc ttctggcgct
      541 gccgccgccg ccgccccccg gaggtgctgt gccgcccgct gcccccgttg ccgcccgaga
      601 gggccgcctg ccgcctggcc ttagcgcgtc gccacagccc tccagcgtcg cgcctcggcg
      661 gccgcaggaa ccacgatgag aggcaggagc tgctcctggc tgaggggctt caaccactcg
      721 ccgaggagga gcagagggcc taggaggacc ccgggcgtgg accacccgcc ctggcagttg
      781 aatggggcgg caattgcggg gcccacctta gaccgaaggg gaaaaccc
//