LOCUS AF016535 4192 bp mRNA linear HUM 03-SEP-1997 DEFINITION Homo sapiens P-glycoprotein (mdr1) mRNA, complete cds. ACCESSION AF016535 VERSION AF016535.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4192) AUTHORS Chen,C.J., Chin,J.E., Ueda,K., Clark,D.P., Pastan,I., Gottesman,M.M. and Roninson,I.B. TITLE Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells JOURNAL Cell 47 (3), 381-389 (1986) PUBMED 2876781 REFERENCE 2 (bases 1 to 4192) AUTHORS Chen,G., Duran,G.E., Steger,K.A., Lacayo,N.J., Jaffrezou,J.P., Dumontet,C. and Sikic,B.I. TITLE Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins JOURNAL J. Biol. Chem. 272 (9), 5974-5982 (1997) PUBMED 9038218 REFERENCE 3 (bases 1 to 4192) AUTHORS Chen,G., Lacayo,N.J., Steger,K.A. and Sikic,B.I. TITLE Direct Submission JOURNAL Submitted (28-JUL-1997) Medicine, Stanford University School of Medicine, Stanford, CA 94306, USA FEATURES Location/Qualifiers source 1..4192 /db_xref="H-InvDB:HIT000062400" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="7" /map="7q21.1" /clone="8.1" /cell_line="MES-SA/DxP" /cell_type="drug-resistant uterine sarcoma" gene 1..4192 /gene="mdr1" /note="multidrug-resistance gene" CDS 120..3959 /gene="mdr1" /function="transporter protein" /note="multidrug-resistance" /codon_start=1 /product="P-glycoprotein" /protein_id="AAB69423.1" /translation="MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSN WLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTG FFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEI GWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVI LAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELER YNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTV FSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLE FRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMV SVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANA YDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA VVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL VTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLS TKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTR IDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQ DVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQL TLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQK FEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFED VLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTL EGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDP LAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVR AAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSA LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ KGIYFSMVSVQAGTKRQ" variation 659 /gene="mdr1" /citation=[1] /replace="t" variation 673..674 /gene="mdr1" /citation=[1] /replace="tt" variation 1351 /gene="mdr1" /citation=[1] /replace="c" variation 1428^1429 /gene="mdr1" /citation=[1] /replace="ttc" variation 3551 /gene="mdr1" /citation=[1] /replace="c" BASE COUNT 1243 a 797 c 1028 g 1124 t ORIGIN 1 tccaagctca aagaagcaga ggccgctgtt cgtttccttt aggtctttcc actaaagtcg 61 gagtatcttc ttccaagatt tcacgtcttg gtggccgttc caaggagcgc gaggtcggga 121 tggatcttga aggggaccgc aatggaggag caaagaagaa gaactttttt aaactgaaca 181 ataaaagtga aaaagataag aaggaaaaga aaccaactgt cagtgtattt tcaatgtttc 241 gctattcaaa ttggcttgac aagttgtata tggtggtggg aactttggct gccatcatcc 301 atggggctgg acttcctctc atgatgctgg tgtttggaga aatgacagat atctttgcaa 361 atgcaggaaa tttagaagat ctgatgtcaa acatcactaa tagaagtgat atcaatgata 421 cagggttctt catgaatctg gaggaagaca tgaccaggta tgcctattat tacagtggaa 481 ttggtgctgg ggtgctggtt gctgcttaca ttcaggtttc attttggtgc ctggcagctg 541 gaagacaaat acacaaaatt agaaaacagt tttttcatgc tataatgcga caggagatag 601 gctggtttga tgtgcacgat gttggggagc ttaacacccg acttacagat gatgtctcca 661 agattaatga aggaattggt gacaaaattg gaatgttctt tcagtcaatg gcaacatttt 721 tcactgggtt tatagtagga tttacacgtg gttggaagct aacccttgtg attttggcca 781 tcagtcctgt tcttggactg tcagctgctg tctgggcaaa gatactatct tcatttactg 841 ataaagaact cttagcgtat gcaaaagctg gagcagtagc tgaagaggtc ttggcagcaa 901 ttagaactgt gattgcattt ggaggacaaa agaaagaact tgaaaggtac aacaaaaatt 961 tagaagaagc taaaagaatt gggataaaga aagctattac agccaatatt tctataggtg 1021 ctgctttcct gctgatctat gcatcttatg ctctggcctt ctggtatggg accaccttgg 1081 tcctctcagg ggaatattct attggacaag tactcactgt attttctgta ttaattgggg 1141 cttttagtgt tggacaggca tctccaagca ttgaagcatt tgcaaatgca agaggagcag 1201 cttatgaaat cttcaagata attgataata agccaagtat tgacagctat tcgaagagtg 1261 ggcacaaacc agataatatt aagggaaatt tggaattcag aaatgttcac ttcagttacc 1321 catctcgaaa agaagttaag atcttgaagg gtctgaacct gaaggtgcag agtgggcaga 1381 cggtggccct ggttggaaac agtggctgtg ggaagagcac aacagtccag ctgatgcaga 1441 ggctctatga ccccacagag gggatggtca gtgttgatgg acaggatatt aggaccataa 1501 atgtaaggtt tctacgggaa atcattggtg tggtgagtca ggaacctgta ttgtttgcca 1561 ccacgatagc tgaaaacatt cgctatggcc gtgaaaatgt caccatggat gagattgaga 1621 aagctgtcaa ggaagccaat gcctatgact ttatcatgaa actgcctcat aaatttgaca 1681 ccctggttgg agagagaggg gcccagttga gtggtgggca gaagcagagg atcgccattg 1741 cacgtgccct ggttcgcaac cccaagatcc tcctgctgga tgaggccacg tcagccttgg 1801 acacagaaag cgaagcagtg gttcaggtgg ctctggataa ggccagaaaa ggtcggacca 1861 ccattgtgat agctcatcgt ttgtctacag ttcgtaatgc tgacgtcatc gctggtttcg 1921 atgatggagt cattgtggag aaaggaaatc atgatgaact catgaaagag aaaggcattt 1981 acttcaaact tgtcacaatg cagacagcag gaaatgaagt tgaattagaa aatgcagctg 2041 atgaatccaa aagtgaaatt gatgccttgg aaatgtcttc aaatgattca agatccagtc 2101 taataagaaa aagatcaact cgtaggagtg tccgtggatc acaagcccaa gacagaaagc 2161 ttagtaccaa agaggctctg gatgaaagta tacctccagt ttccttttgg aggattatga 2221 agctaaattt aactgaatgg ccttattttg ttgttggtgt attttgtgcc attataaatg 2281 gaggcctgca accagcattt gcaataatat tttcaaagat tataggggtt tttacaagaa 2341 ttgatgatcc tgaaacaaaa cgacagaata gtaacttgtt ttcactattg tttctagccc 2401 ttggaattat ttcttttatt acatttttcc ttcagggttt cacatttggc aaagctggag 2461 agatcctcac caagcggctc cgatacatgg ttttccgatc catgctcaga caggatgtga 2521 gttggtttga tgaccctaaa aacaccactg gagcattgac taccaggctc gccaatgatg 2581 ctgctcaagt taaaggggct ataggttcca ggcttgctgt aattacccag aatatagcaa 2641 atcttgggac aggaataatt atatccttca tctatggttg gcaactaaca ctgttactct 2701 tagcaattgt acccatcatt gcaatagcag gagttgttga aatgaaaatg ttgtctggac 2761 aagcactgaa agataagaaa gaactagaag gtgctgggaa gatcgctact gaagcaatag 2821 aaaacttccg aaccgttgtt tctttgactc aggagcagaa gtttgaacat atgtatgctc 2881 agagtttgca ggtaccatac agaaactctt tgaggaaagc acacatcttt ggaattacat 2941 tttccttcac ccaggcaatg atgtattttt cctatgctgg atgtttccgg tttggagcct 3001 acttggtggc acataaactc atgagctttg aggatgttct gttagtattt tcagctgttg 3061 tctttggtgc catggccgtg gggcaagtca gttcatttgc tcctgactat gccaaagcca 3121 aaatatcagc agcccacatc atcatgatca ttgaaaaaac ccctttgatt gacagctaca 3181 gcacggaagg cctaatgccg aacacattgg aaggaaatgt cacatttggt gaagttgtat 3241 tcaactatcc cacccgaccg gacatcccag tgcttcaggg actgagcctg gaggtgaaga 3301 agggccagac gctggctctg gtgggcagca gtggctgtgg gaagagcaca gtggtccagc 3361 tcctggagcg gttctacgac cccttggcag ggaaagtgct gcttgatggc aaagaaataa 3421 agcgactgaa tgttcagtgg ctccgagcac acctgggcat cgtgtcccag gagcccatcc 3481 tgtttgactg cagcattgct gagaacattg cctatggaga caacagccgg gtggtgtcac 3541 aggaagagat tgtgagggca gcaaaggagg ccaacataca tgccttcatc gagtcactgc 3601 ctaataaata tagcactaaa gtaggagaca aaggaactca gctctctggt ggccagaaac 3661 aacgcattgc catagctcgt gcccttgtta gacagcctca tattttgctt ttggatgaag 3721 ccacgtcagc tctggataca gaaagtgaaa aggttgtcca agaagccctg gacaaagcca 3781 gagaaggccg cacctgcatt gtgattgctc accgcctgtc caccatccag aatgcagact 3841 taatagtggt gtttcagaat ggcagagtca aggagcatgg cacgcatcag cagctgctgg 3901 cacagaaagg catctatttt tcaatggtca gtgtccaggc tggaacaaag cgccagtgaa 3961 ctctgactgt atgagatgtt aaatactttt taatatttgt ttagatatga catttattca 4021 aagttaaaag caaacactta cagaattatg aagaggtatc tgtttaacat ttcctcagtc 4081 aagttcagag tcttcagaga cttcgtaatt aaaggaacag agtgagagac atcatcaagt 4141 ggagagaaat catagtttaa actgcattat aaattttata acagaattaa ag //