LOCUS       AF016535                4192 bp    mRNA    linear   HUM 03-SEP-1997
DEFINITION  Homo sapiens P-glycoprotein (mdr1) mRNA, complete cds.
ACCESSION   AF016535
VERSION     AF016535.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4192)
  AUTHORS   Chen,C.J., Chin,J.E., Ueda,K., Clark,D.P., Pastan,I.,
            Gottesman,M.M. and Roninson,I.B.
  TITLE     Internal duplication and homology with bacterial transport proteins
            in the mdr1 (P-glycoprotein) gene from multidrug-resistant human
            cells
  JOURNAL   Cell 47 (3), 381-389 (1986)
   PUBMED   2876781
REFERENCE   2  (bases 1 to 4192)
  AUTHORS   Chen,G., Duran,G.E., Steger,K.A., Lacayo,N.J., Jaffrezou,J.P.,
            Dumontet,C. and Sikic,B.I.
  TITLE     Multidrug-resistant human sarcoma cells with a mutant
            P-glycoprotein, altered phenotype, and resistance to cyclosporins
  JOURNAL   J. Biol. Chem. 272 (9), 5974-5982 (1997)
   PUBMED   9038218
REFERENCE   3  (bases 1 to 4192)
  AUTHORS   Chen,G., Lacayo,N.J., Steger,K.A. and Sikic,B.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-JUL-1997) Medicine, Stanford University School of
            Medicine, Stanford, CA 94306, USA
FEATURES             Location/Qualifiers
     source          1..4192
                     /db_xref="H-InvDB:HIT000062400"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.1"
                     /clone="8.1"
                     /cell_line="MES-SA/DxP"
                     /cell_type="drug-resistant uterine sarcoma"
     gene            1..4192
                     /gene="mdr1"
                     /note="multidrug-resistance gene"
     CDS             120..3959
                     /gene="mdr1"
                     /function="transporter protein"
                     /note="multidrug-resistance"
                     /codon_start=1
                     /product="P-glycoprotein"
                     /protein_id="AAB69423.1"
                     /translation="MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSN
                     WLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTG
                     FFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEI
                     GWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVI
                     LAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELER
                     YNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTV
                     FSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLE
                     FRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMV
                     SVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANA
                     YDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA
                     VVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL
                     VTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLS
                     TKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTR
                     IDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQ
                     DVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQL
                     TLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQK
                     FEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFED
                     VLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTL
                     EGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDP
                     LAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVR
                     AAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSA
                     LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ
                     KGIYFSMVSVQAGTKRQ"
     variation       659
                     /gene="mdr1"
                     /citation=[1]
                     /replace="t"
     variation       673..674
                     /gene="mdr1"
                     /citation=[1]
                     /replace="tt"
     variation       1351
                     /gene="mdr1"
                     /citation=[1]
                     /replace="c"
     variation       1428^1429
                     /gene="mdr1"
                     /citation=[1]
                     /replace="ttc"
     variation       3551
                     /gene="mdr1"
                     /citation=[1]
                     /replace="c"
BASE COUNT         1243 a          797 c         1028 g         1124 t
ORIGIN      
        1 tccaagctca aagaagcaga ggccgctgtt cgtttccttt aggtctttcc actaaagtcg
       61 gagtatcttc ttccaagatt tcacgtcttg gtggccgttc caaggagcgc gaggtcggga
      121 tggatcttga aggggaccgc aatggaggag caaagaagaa gaactttttt aaactgaaca
      181 ataaaagtga aaaagataag aaggaaaaga aaccaactgt cagtgtattt tcaatgtttc
      241 gctattcaaa ttggcttgac aagttgtata tggtggtggg aactttggct gccatcatcc
      301 atggggctgg acttcctctc atgatgctgg tgtttggaga aatgacagat atctttgcaa
      361 atgcaggaaa tttagaagat ctgatgtcaa acatcactaa tagaagtgat atcaatgata
      421 cagggttctt catgaatctg gaggaagaca tgaccaggta tgcctattat tacagtggaa
      481 ttggtgctgg ggtgctggtt gctgcttaca ttcaggtttc attttggtgc ctggcagctg
      541 gaagacaaat acacaaaatt agaaaacagt tttttcatgc tataatgcga caggagatag
      601 gctggtttga tgtgcacgat gttggggagc ttaacacccg acttacagat gatgtctcca
      661 agattaatga aggaattggt gacaaaattg gaatgttctt tcagtcaatg gcaacatttt
      721 tcactgggtt tatagtagga tttacacgtg gttggaagct aacccttgtg attttggcca
      781 tcagtcctgt tcttggactg tcagctgctg tctgggcaaa gatactatct tcatttactg
      841 ataaagaact cttagcgtat gcaaaagctg gagcagtagc tgaagaggtc ttggcagcaa
      901 ttagaactgt gattgcattt ggaggacaaa agaaagaact tgaaaggtac aacaaaaatt
      961 tagaagaagc taaaagaatt gggataaaga aagctattac agccaatatt tctataggtg
     1021 ctgctttcct gctgatctat gcatcttatg ctctggcctt ctggtatggg accaccttgg
     1081 tcctctcagg ggaatattct attggacaag tactcactgt attttctgta ttaattgggg
     1141 cttttagtgt tggacaggca tctccaagca ttgaagcatt tgcaaatgca agaggagcag
     1201 cttatgaaat cttcaagata attgataata agccaagtat tgacagctat tcgaagagtg
     1261 ggcacaaacc agataatatt aagggaaatt tggaattcag aaatgttcac ttcagttacc
     1321 catctcgaaa agaagttaag atcttgaagg gtctgaacct gaaggtgcag agtgggcaga
     1381 cggtggccct ggttggaaac agtggctgtg ggaagagcac aacagtccag ctgatgcaga
     1441 ggctctatga ccccacagag gggatggtca gtgttgatgg acaggatatt aggaccataa
     1501 atgtaaggtt tctacgggaa atcattggtg tggtgagtca ggaacctgta ttgtttgcca
     1561 ccacgatagc tgaaaacatt cgctatggcc gtgaaaatgt caccatggat gagattgaga
     1621 aagctgtcaa ggaagccaat gcctatgact ttatcatgaa actgcctcat aaatttgaca
     1681 ccctggttgg agagagaggg gcccagttga gtggtgggca gaagcagagg atcgccattg
     1741 cacgtgccct ggttcgcaac cccaagatcc tcctgctgga tgaggccacg tcagccttgg
     1801 acacagaaag cgaagcagtg gttcaggtgg ctctggataa ggccagaaaa ggtcggacca
     1861 ccattgtgat agctcatcgt ttgtctacag ttcgtaatgc tgacgtcatc gctggtttcg
     1921 atgatggagt cattgtggag aaaggaaatc atgatgaact catgaaagag aaaggcattt
     1981 acttcaaact tgtcacaatg cagacagcag gaaatgaagt tgaattagaa aatgcagctg
     2041 atgaatccaa aagtgaaatt gatgccttgg aaatgtcttc aaatgattca agatccagtc
     2101 taataagaaa aagatcaact cgtaggagtg tccgtggatc acaagcccaa gacagaaagc
     2161 ttagtaccaa agaggctctg gatgaaagta tacctccagt ttccttttgg aggattatga
     2221 agctaaattt aactgaatgg ccttattttg ttgttggtgt attttgtgcc attataaatg
     2281 gaggcctgca accagcattt gcaataatat tttcaaagat tataggggtt tttacaagaa
     2341 ttgatgatcc tgaaacaaaa cgacagaata gtaacttgtt ttcactattg tttctagccc
     2401 ttggaattat ttcttttatt acatttttcc ttcagggttt cacatttggc aaagctggag
     2461 agatcctcac caagcggctc cgatacatgg ttttccgatc catgctcaga caggatgtga
     2521 gttggtttga tgaccctaaa aacaccactg gagcattgac taccaggctc gccaatgatg
     2581 ctgctcaagt taaaggggct ataggttcca ggcttgctgt aattacccag aatatagcaa
     2641 atcttgggac aggaataatt atatccttca tctatggttg gcaactaaca ctgttactct
     2701 tagcaattgt acccatcatt gcaatagcag gagttgttga aatgaaaatg ttgtctggac
     2761 aagcactgaa agataagaaa gaactagaag gtgctgggaa gatcgctact gaagcaatag
     2821 aaaacttccg aaccgttgtt tctttgactc aggagcagaa gtttgaacat atgtatgctc
     2881 agagtttgca ggtaccatac agaaactctt tgaggaaagc acacatcttt ggaattacat
     2941 tttccttcac ccaggcaatg atgtattttt cctatgctgg atgtttccgg tttggagcct
     3001 acttggtggc acataaactc atgagctttg aggatgttct gttagtattt tcagctgttg
     3061 tctttggtgc catggccgtg gggcaagtca gttcatttgc tcctgactat gccaaagcca
     3121 aaatatcagc agcccacatc atcatgatca ttgaaaaaac ccctttgatt gacagctaca
     3181 gcacggaagg cctaatgccg aacacattgg aaggaaatgt cacatttggt gaagttgtat
     3241 tcaactatcc cacccgaccg gacatcccag tgcttcaggg actgagcctg gaggtgaaga
     3301 agggccagac gctggctctg gtgggcagca gtggctgtgg gaagagcaca gtggtccagc
     3361 tcctggagcg gttctacgac cccttggcag ggaaagtgct gcttgatggc aaagaaataa
     3421 agcgactgaa tgttcagtgg ctccgagcac acctgggcat cgtgtcccag gagcccatcc
     3481 tgtttgactg cagcattgct gagaacattg cctatggaga caacagccgg gtggtgtcac
     3541 aggaagagat tgtgagggca gcaaaggagg ccaacataca tgccttcatc gagtcactgc
     3601 ctaataaata tagcactaaa gtaggagaca aaggaactca gctctctggt ggccagaaac
     3661 aacgcattgc catagctcgt gcccttgtta gacagcctca tattttgctt ttggatgaag
     3721 ccacgtcagc tctggataca gaaagtgaaa aggttgtcca agaagccctg gacaaagcca
     3781 gagaaggccg cacctgcatt gtgattgctc accgcctgtc caccatccag aatgcagact
     3841 taatagtggt gtttcagaat ggcagagtca aggagcatgg cacgcatcag cagctgctgg
     3901 cacagaaagg catctatttt tcaatggtca gtgtccaggc tggaacaaag cgccagtgaa
     3961 ctctgactgt atgagatgtt aaatactttt taatatttgt ttagatatga catttattca
     4021 aagttaaaag caaacactta cagaattatg aagaggtatc tgtttaacat ttcctcagtc
     4081 aagttcagag tcttcagaga cttcgtaatt aaaggaacag agtgagagac atcatcaagt
     4141 ggagagaaat catagtttaa actgcattat aaattttata acagaattaa ag
//