LOCUS AF005058 5161 bp DNA linear HUM 21-SEP-2000 DEFINITION Homo sapiens chemokine receptor (CXCR-4) gene, complete cds. ACCESSION AF005058 VERSION AF005058.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5161) AUTHORS Wegner,S.A., Ehrenberg,P.K., Chang,G., Dayhoff,D.E., Sleeker,A.L. and Michael,N.L. TITLE Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1 JOURNAL J. Biol. Chem. 273 (8), 4754-4760 (1998) PUBMED 9468539 REFERENCE 2 (bases 1 to 5161) AUTHORS Wegner,S.A., Ehrenberg,P.K., Chang,G., Dayhoff,D.E. and Michael,N.L. TITLE Direct Submission JOURNAL Submitted (21-MAY-1997) Division of Retrovirology, Walter Reed Army Institute of Research, 13 Taft Court, Suite 200, Rockville, MD 20850, USA FEATURES Location/Qualifiers source 1..5161 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" gene 2..5161 /gene="CXCR-4" regulatory 919..923 /regulatory_class="TATA_box" /gene="CXCR-4" mRNA join(950..1052,3185..4760) /gene="CXCR-4" /product="chemokine receptor" exon 950..1052 /gene="CXCR-4" /number=1 5'UTR 950..1037 /gene="CXCR-4" CDS join(1038..1052,3185..4228) /gene="CXCR-4" /note="seven-transmembrane G-coupled receptor for the CXC chemokine SDF-1; entry co-receptor for HIV-1 strains with the syncytium-inducing phenotype" /codon_start=1 /product="chemokine receptor" /protein_id="AAB93982.1" /translation="MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTI YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANW YFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGV WIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSC YCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEF ENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKR GGHSSVSTESESSSFHSS" intron 1053..3184 /gene="CXCR-4" /number=1 exon 3185..4760 /gene="CXCR-4" /number=2 3'UTR 4229..4760 /gene="CXCR-4" regulatory 4726..4731 /regulatory_class="polyA_signal_sequence" /gene="CXCR-4" BASE COUNT 1160 a 1338 c 1287 g 1376 t ORIGIN 1 tttcatctct ccgggcttat ttgctggttt ctccgaatgc gggccttgtc tggttcacgc 61 tggatcccca acgcctagaa cagtgcgtgg cacgcagttc gtccttctat aaatatcgga 121 ctaaatgcat ctctgtgatg gtaataccca cacggtgttg tgagaatgaa tgagtgattc 181 tgtgcaagtt cctagtgatc tgttacaaaa agtactggtc gctaaattac tcttataata 241 aagcatactt ttaggataat aaagcactat tcgcgaattg gttaccgcta ttatgaaatt 301 actgagcaat acatatctac atctgatcag tctccagaat tatgccaaat cctaccttct 361 tctgaaagta tctcctaatt atctgcacct gaccctagtg atgctgtgaa tgtgcaagta 421 tagctacatc ctccgaagga aggatcttta ctccttttac ctcctgaatg ggctgcgtct 481 gctgaaagcg cgggggaatg ggcggttgga agcttggccc tacttccagc attgccgcct 541 actggttggg ttactccagc aagtcactcc ccttccctgg gcctcagtgt ctctactgta 601 gcattcccag gtctggaatt ccatccactt tagcaaggat ggacgcgcca cagagagacg 661 cgttcctagc ccgcgcttcc cacctgtctt caggcgcatc ccgcttccct caaacttagg 721 aaatgcctct gggaggtcct gtccggctcc ggactcacta ccgaccaccc gcaaacagca 781 gggtcccctg ggcttcccaa gccgcgcacc tctccgcccc gcccctgcgc cctccttcct 841 cgcgtctgcc cctctccccc accccgcctt ctccctcccc gccccagcgg cgcatgcgcc 901 gcgctcggag cgtgttttta taaaagtccg gccgcggcca gaaacttcag tttgttggct 961 gcggcagcag gtagcaaagt gacgccgagg gcctgagtgc tccagtagcc accgcatctg 1021 gagaaccagc ggttaccatg gaggggatca gtgtaagtcc agtttcaacc tgctttgtca 1081 taaatgtaca aacgtttgaa cttagagcgc agcccctctc cgagcgggca gaagcggcca 1141 ggacattgga ggtacccgta ctccaaaaaa gggtcaccga aaggagtttt cttgaccatg 1201 cctatatagt gcgggtgggt ggggggggag caggattgga atctttttct ctgtgagtcg 1261 aggagaaacg actggaaaga gcgttccagt ggctgcatgt gtctccccct tgagtcccgc 1321 cgcgcgcggc ggcttgcacg ctgtttgcaa acgtaagaac attctgtgca caagtgcaga 1381 gaaggcgtgc gcgctgcctc gggactcaga ccaccggtct cttccttggg gaagcgggga 1441 tgtcttggag cgagttacat tgtctgaatt tagaggcgga gggcggcgtg cctgggctga 1501 cttcccagga ggagattgcg cccgctttaa cttcggggtt aagcgcctgg tgactgttct 1561 tgacactggg tgcgtgtttg ttaaactctg tgcggccgac ggagctgtgc cagtctccca 1621 gcacagtagg cagagggcgg gagaggcggg tggacccacc gcgccgatcc tctgagggga 1681 tcgagtggtg gcagcagcta ggagttgatc cgcccgcgcg ctttgggttt gagggggaaa 1741 ccttcccgcc gtccgaagcg cgcctcttcc ccacggccgc gagtgggtcc tgcagttcga 1801 gagtttgggg tcgtgcagag gtcagcggag tggtttgacc tcccctttga caccgcgcag 1861 ctgccagccc tgagatttgc gctccgggga taggagcggg tacggggtga ggggcggggg 1921 cggttaagac cgcacctggg ctgccaggtc gccgccgcga agactggcag gtgcaagtgg 1981 ggaaaccgtt tggctctctc cgagtccagt tgtgatgttt aaccgtcggt ggtttccaga 2041 aaccttttga aaccctcttg ctagggagtt tttggtttcc tgcagcggcg cgcaattcaa 2101 agacgctcgc ggcggagccg cccagtcgct ccccagcacc ctgtgggaca gagcctggcg 2161 tgtcgcccag cggagcccct gcagcgctgc ttgcgggcgg ttggcgtggg tgtagtgggc 2221 agccgcggcg gcccggggct ggacgacccg gccccccgcg tgcccaccgc ctggaggctt 2281 ccagctgccc acctccggcc gggttaactg gatcagtggc ggggtaatgg gaagccaccc 2341 gggagagtga ggaaatgaaa cttggggcga ggaccacggg tgcagacccc gttaccttct 2401 ccacccagga aaatgccccg ctccctaacg tcccaaacgc gccaagtgat aaacacgagg 2461 atggcaagag acccacacac cggaggagcg cccgcttggg ggaggaggtg ccgtttgttc 2521 attttctgac actcccgccc aatatacccc aagcaccgaa gggccttcgt tttaagaccg 2581 cattctcttt acccactaca agttgcttga agcccagaat ggtttgtatt taggcaggcg 2641 tgggaaaatt aagtttttgc gctttaggag aatgagtctt tgcaacgccc ccgccctccc 2701 cccgtgatcc tcccttctcc cctcttccct ccctgggcga aaaacttctt acaaaaagtt 2761 aatcactgcc cctcctagca gcacccaccc caccccccac gccgcctggg agtggcctct 2821 ttgtgtgtat tttttttttc ctcctaagga aggttttttt tcttccctct agtgggcggg 2881 gcagaggagt tagccaagat gtgactttga aaccctcagc gtctcagtgc ccttttgttc 2941 taaacaaaga attttgtaat tggttctacc aaagaaggat ataatgaagt cactatggga 3001 aaagatgggg aggagagttg taggattcta cattaattct cttgtgccct tagcccacta 3061 cttcagaatt tcctgaagaa agcaagcctg aattggtttt ttaaattgct ttaaaaattt 3121 tttttaactg ggttaatgct tgctgaattg gaagtgaatg tccattcctt tgcctctttt 3181 gcagatatac acttcagata actacaccga ggaaatgggc tcaggggact atgactccat 3241 gaaggaaccc tgtttccgtg aagaaaatgc taatttcaat aaaatcttcc tgcccaccat 3301 ctactccatc atcttcttaa ctggcattgt gggcaatgga ttggtcatcc tggtcatggg 3361 ttaccagaag aaactgagaa gcatgacgga caagtacagg ctgcacctgt cagtggccga 3421 cctcctcttt gtcatcacgc ttcccttctg ggcagttgat gccgtggcaa actggtactt 3481 tgggaacttc ctatgcaagg cagtccatgt catctacaca gtcaacctct acagcagtgt 3541 cctcatcctg gccttcatca gtctggaccg ctacctggcc atcgtccacg ccaccaacag 3601 tcagaggcca aggaagctgt tggctgaaaa ggtggtctat gttggcgtct ggatccctgc 3661 cctcctgctg actattcccg acttcatctt tgccaacgtc agtgaggcag atgacagata 3721 tatctgtgac cgcttctacc ccaatgactt gtgggtggtt gtgttccagt ttcagcacat 3781 catggttggc cttatcctgc ctggtattgt catcctgtcc tgctattgca ttatcatctc 3841 caagctgtca cactccaagg gccaccagaa gcgcaaggcc ctcaagacca cagtcatcct 3901 catcctggct ttcttcgcct gttggctgcc ttactacatt gggatcagca tcgactcctt 3961 catcctcctg gaaatcatca agcaagggtg tgagtttgag aacactgtgc acaagtggat 4021 ttccatcacc gaggccctag ctttcttcca ctgttgtctg aaccccatcc tctatgcttt 4081 ccttggagcc aaatttaaaa cctctgccca gcacgcactc acctctgtga gcagagggtc 4141 cagcctcaag atcctctcca aaggaaagcg aggtggacat tcatctgttt ccactgagtc 4201 tgagtcttca agttttcact ccagctaaca cagatgtaaa agactttttt ttatacgata 4261 aataactttt ttttaagtta cacatttttc agatataaaa gactgaccaa tattgtacag 4321 tttttattgc ttgttggatt tttgtcttgt gtttctttag tttttgtgaa gtttaattga 4381 cttatttata taaatttttt ttgtttcata ttgatgtgtg tctaggcagg acctgtggcc 4441 aagttcttag ttgctgtatg tctcgtggta ggactgtaga aaagggaact gaacattcca 4501 gagcgtgtag tgaatcacgt aaagctagaa atgatcccca gctgtttatg catagataat 4561 ctctccattc ccgtggaacg tttttcctgt tcttaagacg tgattttgct gtagaagatg 4621 gcacttataa ccaaagccca aagtggtata gaaatgctgg tttttcagtt ttcaggagtg 4681 ggttgatttc agcacctaca gtgtacagtc ttgtattaag ttgttaataa aagtacatgt 4741 taaacttact tagtgttatg ttctgatttc tgttgacatt cttttggcta gtagaagaca 4801 aaagtaatac atttatggta tgcaaagcac tatcctaggt atttcattgt aatattttac 4861 ttacccctta tcacaactct gatagattct gcttctgtta ctaattacat tttatagaag 4921 aggaaacgga ggcacagaaa gcctaagtaa cttggttaaa ggcatgtagt aagtatcaaa 4981 tcctgtattt taaaccaggt aacatgactt aacgaatctg aagccttcac cactttaaat 5041 tcaaatggaa gtttagaaat ggccagccag cacctatttg tatgaaaggt catctttcag 5101 aggataagca tgtataaaga agaaaaggta tgcagtcgtg tttggatttt actccaccat 5161 c //