LOCUS HSAF000295 1256 bp mRNA linear HUM 05-NOV-1998
DEFINITION Homo sapiens nk-2-related transcription factor (NKX-2.8) mRNA,
complete cds.
ACCESSION AF000295
VERSION AF000295.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1256)
AUTHORS Apergis,G.A., Crawford,N., Ghosh,D., Steppan,C.M., Vorachek,W.R.,
Wen,P. and Locker,J.
TITLE A novel nk-2-related transcription factor associated with human
fetal liver and hepatocellular carcinoma
JOURNAL J. Biol. Chem. 273 (5), 2917-2925 (1998)
PUBMED 9446603
REFERENCE 2 (bases 1 to 1256)
AUTHORS Apergis,G., Crawford,N., Ghosh,D., Steppan,C., Vorachek,W.R.,
Wen,P. and Locker,J.
TITLE Direct Submission
JOURNAL Submitted (11-APR-1997) Pathology, University of Pittsburgh, BST
S405, Pittsburgh, PA 15261, USA
FEATURES Location/Qualifiers
source 1..1256
/db_xref="H-InvDB:HIT000061568"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HepG2"
/tissue_type="liver"
/dev_stage="fetal"
gene 1..1256
/gene="NKX-2.8"
/note="homeobox gene"
CDS 200..919
/gene="NKX-2.8"
/codon_start=1
/product="nk-2-related transcription factor"
/protein_id="AAC71081.1"
/translation="MATSGRLSFTVRSLLGLPEQDAQHLPRREPEPRAPQPDPCAAWL
DSERGHYPSSDESSLETSPPDSSQRPSARPASPGSDAEKRKKRRVLFSKAQTLELERR
FRQQRYLSAPEREQLASLLRLTPTQVKIWFQNHRYKLKRARAPGAAESPDLAASAELH
AAPGLLRRVVVPVLVRDGQPCGGGGGGEVGTAAAQEKCGAPPAAACPLPGYPAFGPGS
ALGLFPAYQHLASPALVSWNW"
variation 246
/gene="NKX-2.8"
/note="polymorphism, G to C, changes Gly to Ala"
/replace="c"
misc_feature 356..357
/gene="NKX-2.8"
/note="position of intron"
BASE COUNT 207 a 451 c 377 g 221 t
ORIGIN
1 ctggagaccc ggacctcggc tttcaaagcg gctgggtggg aagagctgtt tatataaaca
61 gagattccgc tgtaaatgcg ctaatatccc ggctgccagc gcatggcgag cgcctcccac
121 gcccatccgt aggagcggcg tcccggccgc ccctccgttc ccagcctgcc ctgcccccgc
181 ctccttcccc tcctcggcca tggccacctc tggacgcctg agcttcaccg tgcgcagcct
241 tctaggttta cccgagcagg acgcgcaaca cctgccgagg cgggagccag aaccacgcgc
301 cccccagccc gacccctgcg ccgcctggct ggattcggag cgcggccact acccttcctc
361 ggacgagagc agcctggaga ccagcccgcc agactcgtcg cagcggccgt ccgctaggcc
421 cgcgtctccg ggctcggacg ccgagaaaag gaagaagcgg cgggtgctat tctccaaggc
481 gcagacgctg gagttggagc ggcgcttccg gcagcagcgg tacctgtctg cgcccgagcg
541 cgagcagctg gcgagcctgc ttcgcctcac gcccacgcag gtcaagatct ggttccagaa
601 tcatcgctac aagctgaagc gtgctcgcgc tccaggggcg gcggagtcgc ctgacctggc
661 agcatccgcc gagctgcacg ccgcgcccgg cctgctgcgt cgcgtggtgg tgccggtgct
721 tgttcgcgac gggcagccgt gcggcggcgg cggcggtggc gaggtgggaa ccgccgcggc
781 ccaggagaag tgcggcgccc ctccagccgc cgcctgccct ctgccgggct accctgcctt
841 cggtcccggc tcggcgcttg gcctcttccc cgcctaccag cacttagcat cccccgccct
901 ggtctcctgg aactggtgag gccgcagggc ggcacctggg gctaccctcg actttggagc
961 gcgctctgcg attggagcag ggccggagcc gaacgcctgg aacgctctcc gtccgcctcc
1021 ctgcagcccc atctccttgg gcgccagggt ccctggcgcg ccctcatcag ccgtcgcgca
1081 agcacacacg agggacgtgt gccagagccc cctccctcac cttccctcca ccgccagccc
1141 cagagttaga ttttatgctt gggccttatt tgtatatttt taaatagcga tttgtatagg
1201 aagcaagtta tttttttaaa aaatagagta tttttcctcg taaaaaaaaa aaaaaa
//