LOCUS AB103618 6974 bp DNA linear HUM 13-SEP-2006 DEFINITION Homo sapiens gene for LTA protein, TNFA protein, complete cds. ACCESSION AB103618 VERSION AB103618.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6974) AUTHORS Shiina,T. TITLE Direct Submission JOURNAL Submitted (19-FEB-2003) to the DDBJ/EMBL/GenBank databases. Contact:Takashi Shiina Tokai University School of Medicine, Molecular Life Sciense 2; Bohseidai, Isehara, Kanagawa 259-1193, Japan REFERENCE 2 AUTHORS Shiina,T., Ota,M., Shimizu,S., Katsuyama,Y., Hashimoto,N., Takasu,M., Anzai,T., Kulski,J.K., Kikkawa,E., Naruse,T., Kimura,N., Yanagiya,K., Watanabe,A., Hosomichi,K., Kohara,S., Iwamoto,C., Umehara,Y., Meyer,A., Wanner,V., Sano,K., Macquin,C., Ikeo,K., Tokunaga,K., Gojobori,T., Inoko,H. and Bahram,S. TITLE Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity JOURNAL Genetics 173, 1555-1570 (2006) COMMENT FEATURES Location/Qualifiers source 1..6974 /cell_line="AKIBA" /cell_type="B cell" /chromosome="6" /db_xref="taxon:9606" /map="6p21.31" /mol_type="genomic DNA" /organism="Homo sapiens" exon 944..1074 /gene="LTA" /number=1 exon 1362..1469 /gene="LTA" /number=2 CDS join(1371..1469,1556..1661,1909..2321) /codon_start=1 /gene="LTA" /note="cytokine; role in lymphoid organ development and germinal centre formation" /product="LTA protein" /protein_id="BAF31278.1" /translation="MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSA AQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVP TSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQ EPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL" exon 1556..1661 /gene="LTA" /number=3 exon 1909..2949 /gene="LTA" /number=4 exon 4289..4555 /gene="TNFA" /number=1 CDS join(4370..4555,5162..5207,5395..5442,5744..6165) /codon_start=1 /gene="TNFA" /note="cytokine; antitumour activity; roles in inflammation of immunomodulation" /product="TNFA protein" /protein_id="BAF31279.1" /translation="MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGA TTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQL QWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIA VSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYL DFAESGQVYFGIIAL" exon 5162..5207 /gene="TNFA" /number=2 exon 5395..5442 /gene="TNFA" /number=3 exon 5744..6963 /gene="TNFA" /number=4 BASE COUNT 1644 a 1967 c 1834 g 1529 t ORIGIN 1 aaataatgta ttggctctgc aaatgcagct tcagaacaag tcccttagct gtccccaccc 61 caccctaagt caccaccctt aagcctcacc catgtggaat tctgaaactt cctttgtaga 121 aaactttgga aggtgtctgc cacattgatc ctggaatgtg tgtttatttg gggttatata 181 aatctgttct gtggaagcca cctgaagtca ggaagagatg gagggcatcc ttcaggagtg 241 agatgagacc tcatcatact tgactgtcca gcatcatctc tgagtaaggg gaccaaaaaa 301 tttatcttcc aaactaggac actttcaaga gtggaagggg gatccattaa tattttcacc 361 tggacaagag gcaaacacca gaatgtcccc gatgaagggg atatataatg gaccttcttg 421 atgtgaaacc tgccagatgg gctggaaagt ccgtatactg ggacaagtat gatttgagtt 481 gtttgggaca aggacagggg tacaagagaa ggaaatgggc aaagagagaa gcctgtactc 541 agccaagggt gcagagatgt tatatatgat tgctcttcag ggaaccgggc ctccagctca 601 caccccagct gctcaaccgc ctcctctctg aattgactgt cccttctttg gaactctagg 661 cctgacccca ctccctggcc ctcccagccc acgattcccc tgacccgact ccctttccca 721 gaactcagtc gcctgaaccc ccagcctgtg gttctctcct aggcctcagc ctttcctgcc 781 tttgactgaa acagcagtat cttctaagcc ctgggggctt ccccgggccc cagccccgac 841 ctagaacccg cccgctgcct gccacgctgc cactgccgct tcctctataa agggacctga 901 gcgtccgggc ccaggggctc cgcacagcag gtgaggctct cctgccccat ctccttgggc 961 tgcccgtgct tcgtgctttg gactaccgcc cagcagtgtc ctgccctctg cctgggcctc 1021 ggtccctcct gcacctgctg cctggatccc cggcctgcct gggcctgggc cttggtgggt 1081 ttggttttgg tttccttctc tgtctctgac tctccatctg tcagtctcat tgtctctgtc 1141 acacattctc tgtttctgcc atgattcctc tctgttccct tcctgtctct ctctgtctcc 1201 ctctgctcac cttggggttt ctctgactgc atcttgtccc cttctctgtc gatctctctc 1261 tcgggggtcg gggggtgctc tctcccaggg cgggaggtct gtcttccgcc gcgtgccccg 1321 ccccgctcac tgtctctctc tctctctctc tttctctgca ggttctcccc atgacaccac 1381 ctgaacgtct cttcctccca agggtgtgtg gcaccaccct acacctcctc cttctggggc 1441 tgctgctggt tctgctgcct ggggcccagg tgaggcagca ggagaatggg ggctgctggg 1501 gtggctcagc caaaccttga gccctagagc ccccctcaac tctgttctcc cctaggggct 1561 ccctggtgtt ggcctcacac cttcagctgc ccagactgcc cgtcagcacc ccaagatgca 1621 tcttgcccac agcaccctca aacctgctgc tcacctcatt ggtaaacatc cacctgacct 1681 cccagacatg tccccaccag ctctcctcct acccctgcct caggaaccca agcatccacc 1741 cctctccccc aacttccccc acgctaaaaa aaacagaggg agcccactcc tatgcctccc 1801 cctgccatcc cccaggaact cagttgttca gtgcccactt cctcagggat tgagacctct 1861 gatccagacc cctgatctcc cacccccatc ccctatggct cttcctagga gaccccagca 1921 agcagaactc actgctctgg agagcaaaca cggaccgtgc cttcctccag gatggtttct 1981 ccttgagcaa caattctctc ctggtcccca ccagtggcat ctacttcgtc tactcccagg 2041 tggtcttctc tgggaaagcc tactctccca aggccacctc ctccccactc tacctggccc 2101 atgaggtcca gctcttctcc tcccagtacc ccttccatgt gcctctcctc agctcccaga 2161 agatggtgta tccagggctg caggaaccct ggctgcactc gatgtaccac ggggctgcgt 2221 tccagctcac ccagggagac cagctatcca cccacacaga tggcatcccc cacctagtcc 2281 tcagccctag tactgtcttc tttggagcct tcgctctgta gaacttggaa aaatccagaa 2341 agaaaaaata attgatttca agaccttctc cccattctgc ctccattctg accatttcag 2401 gggtcgtcac cacctctcct ttggccattc caacagctca agtcttccct gatcaagtca 2461 ccggagcttt caaagaagga attctaggca tcccagggga ccacacctcc ctgaaccatc 2521 cctgatgtct gtctggctga ggatttcaag cctgcctagg aattcccagc ccaaagctgt 2581 tggtctgtcc caccagctag gtggggccta gatccacaca cagaggaaga gcaggcacat 2641 ggaggagctt gggggatgac tagaggcagg gaggggacta tttatgaagg caaaaaaatt 2701 aaattattta tttatggagg atggagagag gggaataata gaagaacatc caaggagaaa 2761 cagagacagg cccaagagat gaagagtgag agggcatgcg cacaaggctg accaagagag 2821 aaagaagtag gcatgaggga tcacagggcc ccagaaggca gggaaaggct ctgaaagcca 2881 gctgccgacc agagccccac acggaggcat ctgcaccctc gatgaagccc aataaacctc 2941 ttttctctga aatgctgtct gcttgtgtgt gtgtgtctgg gagtgagaac ttcccagtct 3001 atctaaggaa tggagggagg gacagagggc tcaaagggag caagagctgt ggggagaaca 3061 aaaggataag ggctcagaga gcttcaggga tatgtgatgg actcaccagg tgaggccgcc 3121 agactgctgc aggggaagca aaggagaagc tgagaagatg aaggaaaagt cagggtctgg 3181 aggggcgggg gtcagggagc tcctgggaga tatggccaca tgtagcggct ctgaggaatg 3241 ggttacagga gacctctggg gagatgtgac cacagcaatg ggtaggagaa tgtccagggc 3301 tatggaagtc gagtatgggg accccccctt aacgaagaca gggccatgta gagggcccca 3361 gggagtgaaa gagcctccag gacctccagg tatggaatac aggggacgtt taagaagata 3421 tggccacaca ctggggccct gagaagtgag agcttcatga aaaaaatcag ggaccccaga 3481 gttccttgga agccaagact gaaaccagca ttatgagtct ccgggtcaga atgaaagaag 3541 aaggcctgcc ccagtggggt ctgtgaattc ccgggggtga tttcactccc cggggctgtc 3601 ccaggcttgt ccctgctacc cccacccagc ctttcctgag gcctcaagcc tgccaccaag 3661 cccccagctc cttctccccg cagggaccca aacacaggcc tcaggactca acacagcttt 3721 tccctccaac cccgttttct ctccctcaag gactcagctt tctgaagccc ctcccagttc 3781 tagttctatc tttttcctgc atcctgtctg gaagttagaa ggaaacagac cacagacctg 3841 gtccccaaaa gaaatggagg caataggttt tgaggggcat ggggacgggg ttcagcctcc 3901 agggtcctac acacaaatca gtcagtggcc cagaagaccc ccctcggaat cggagcaggg 3961 aggatgggga gtgtgagggg tatccttgat gcttgtgtgt ccccaacttt ccaaatcccc 4021 gcccccgcga tggagaagaa accgagacag aaggtgcagg gcccactacc gcttcctcca 4081 gatgagctca tgggtttctc caccaaggaa gttttccgct ggttgaatga ttctttcccc 4141 gccctcctct cgccccaggg acatataaag gcagttgttg gcacacccag ccagcagacg 4201 ctccctcagc aaggacagca gaggaccagc taagagggag agaagcaact acagaccccc 4261 cctgaaaaca accctcagac gccacatccc ctgacaagct gccaggcagg ttctcttcct 4321 ctcacatact gacccacggc tccaccctct ctcccctgga aaggacacca tgagcactga 4381 aagcatgatc cgggacgtgg agctggccga ggaggcgctc cccaagaaga caggggggcc 4441 ccagggctcc aggcggtgct tgttcctcag cctcttctcc ttcctgatcg tggcaggcgc 4501 caccacgctc ttctgcctgc tgcactttgg agtgatcggc ccccagaggg aagaggtgag 4561 tgcctggcca gccttcatcc actctcccac ccaaggggaa atggagacgc aagagaggga 4621 gagagatggg atgggtgaaa gatgtgcgct gatagggagg gatggagaga aaaaaacgtg 4681 gagaaagacg gggatgcaga aagagatgtg gcaagagatg gggaagagag agagagaaag 4741 atggagagac aggatgtctg gcacatggaa ggtgctcact aagtgtgtat ggagtgaatg 4801 aatgaatgaa tgaatgaaca agcagatata taaataagat atggagacag atgtggggtg 4861 tgagaagaga gatgggggaa gaaacaagtg atatgaataa agatggtgag acagaaagag 4921 cgggaaatat gacagctaag gagagagatg ggggagataa ggagagaaga agatagggtg 4981 tctggcacac agaagacact cagggaaaga gctgttgaat gcctggaagg tgaatacaca 5041 gatgaatgga gagagaaaac cagacacctc agggctaaga gcgcaggcca gacaggcagc 5101 cagctgttcc tcctttaagg gtgactccct cgatgttaac cattctcctt ctccccaaca 5161 gttccccagg gacctctctc taatcagccc tctggcccag gcagtcagta agtgtctcca 5221 aacctctttc ctaattctgg gtttgggttt gggggtaggg ttagtaccgg tatggaagca 5281 gtgggggaaa tttaaagttt tggtcttggg ggaggatgga tggaggtgaa agtagggggg 5341 tattttctag gaagtttaag ggtctcagct ttttcttttc tctctcctct tcaggatcat 5401 cttctcgaac cccgagtgac aagcctgtag cccatgttgt aggtaagagc tctgaggatg 5461 tgtcttggaa cttggagggc taggatttgg ggattgaagc ccggctgatg gtaggcagaa 5521 cttggagaca atgtgagaag gactcgctga gctcaaggga agggtggagg aacagcacag 5581 gccttagtgg gatactcaga acgtcatggc caggtgggat gtgggatgac agacagagag 5641 gacaggaacc ggatgtgggg tgggcagagc tcgagggcca ggatgtggag agtgaaccga 5701 catggccaca ctgactctcc tctccctctc tccctccctc cagcaaaccc tcaagctgag 5761 gggcagctcc agtggctgaa ccgccgggcc aatgccctcc tggccaatgg cgtggagctg 5821 agagataacc agctggtggt gccatcagag ggcctgtacc tcatctactc ccaggtcctc 5881 ttcaagggcc aaggctgccc ctccacccat gtgctcctca cccacaccat cagccgcatc 5941 gccgtctcct accagaccaa ggtcaacctc ctctctgcca tcaagagccc ctgccagagg 6001 gagaccccag agggggctga ggccaagccc tggtatgagc ccatctatct gggaggggtc 6061 ttccagctgg agaagggtga ccgactcagc gctgagatca atcggcccga ctatctcgac 6121 tttgccgagt ctgggcaggt ctactttggg atcattgccc tgtgaggagg acgaacatcc 6181 aaccttccca aacgcctccc ctgccccaat ccctttatta ccccctcctt cagacaccct 6241 caacctcttc tggctcaaaa agagaattgg gggcttaggg tcggaaccca agcttagaac 6301 tttaagcaac aagaccacca cttcgaaacc tgggattcag gaatgtgtgg cctgcacagt 6361 gaagtgctgg caaccactaa gaattcaaac tggggcctcc agaactcact ggggcctaca 6421 gctttgatcc ctgacatctg gaatctggag accagggagc ctttggttct ggccagaatg 6481 ctgcaggact tgagaagacc tcacctagaa attgacacaa gtggacctta ggccttcctc 6541 tctccagatg tttccagact tccttgagac acggagccca gccctcccca tggagccagc 6601 tccctctatt tatgtttgca cttgtgatta tttattattt atttattatt tatttattta 6661 cagatgaatg tatttatttg ggagaccggg gtatcctggg ggacccaatg taggagctgc 6721 cttggctcag acatgttttc cgtgaaaacg gagctgaaca ataggctgtt cccatgtagc 6781 cccctggcct ctgtgccttc ttttgattat gttttttaaa atatttatct gattaagttg 6841 tctaaacaat gctgatttgg tgaccaactg tcactcattg ctgagcctct gctccccagg 6901 ggagttgtgt ctgtaatcgc cctactattc agtggcgaga aataaagttt gcttagaaaa 6961 gaaacatggt ctcc //