LOCUS       AB006987                6017 bp    DNA     linear   HUM 25-DEC-2002
DEFINITION  Homo sapiens gene for 25-hydroxyvitamin D3 1-alpha-hydroxylase,
            complete cds.
ACCESSION   AB006987
VERSION     AB006987.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6017)
  AUTHORS   Monkawa,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-SEP-1997) to the DDBJ/EMBL/GenBank databases.
            Contact:Toshiaki Monkawa
            School of Medicine, Keio University, Department of Internal
            Medicine; 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan
REFERENCE   2
  AUTHORS   Monkawa,T., Yoshida,T., Wakino,S., Shinki,T., Anazawa,H.,
            DeLuca,H.F., Suda,T., Hayashi,M. and Saruta,T.
  TITLE     Molecular cloning of cDNA and genomic DNA for human
            25-hydroxyvitamin D3 1alpha-hydroxylase
  JOURNAL   Biochem. Biophys. Res. Commun. 239, 527-533 (1997)
COMMENT     
FEATURES             Location/Qualifiers
     source          1..6017
                     /db_xref="taxon:9606"
                     /mol_type="genomic DNA"
                     /organism="Homo sapiens"
     exon            <285..600
                     /number=1
     CDS             join(406..600,1250..1440,1949..2151,2237..2437,2522..2694,
                     2898..3070,3272..3350,3640..3837,4193..4306)
                     /product="25-hydroxyvitamin D3 1-alpha-hydroxylase"
                     /protein_id="BAA23418.1"
                     /translation="MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPS
                     TPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEG
                     PRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNN
                     VVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDT
                     ETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAA
                     MRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELS
                     RHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPD
                     KDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGF
                     GKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR
                     "
     intron          601..1249
                     /number=1
     exon            1250..1440
                     /number=2
     intron          1441..1948
                     /number=2
     exon            1949..2151
                     /number=3
     intron          2152..2236
                     /number=3
     exon            2237..2437
                     /number=4
     intron          2438..2521
                     /number=4
     exon            2522..2694
                     /number=5
     intron          2695..2897
                     /number=5
     exon            2898..3070
                     /number=6
     intron          3071..3271
                     /number=6
     exon            3272..3350
                     /number=7
     intron          3351..3639
                     /number=7
     exon            3640..3837
                     /number=8
     intron          3838..4192
                     /number=8
     exon            4193..5109
                     /number=9
BASE COUNT         1342 a         1696 c         1590 g         1389 t
ORIGIN      
        1 gaattcctga ggatgggcct aaaggggctg ggctcactgg tagaagtggg aatatcagag
       61 actgactagt gtagcttggt cacctagtcc ctactaaaaa gccttatagc ctttcctagg
      121 atgagacttt gaggctccta gacaaaggca ctctcccagg aggaaaatct taggccctcc
      181 ctcccatgag ggtcattgca acatgagacc caagggagtt gtgaagtcag ccccagcccc
      241 gcctactgtt cctgggtgct aatccccagc acagaccact caggaggagg gattggctga
      301 ggagcttgga gagggggcgt catcacctca cccaaaggtt aaataggggt tgagatatga
      361 tgctcaggag aagcgctttc tttcgcgagc accctgaacc agaccatgac ccagaccctc
      421 aagtacgcct ccagagtgtt ccatcgcgtc cgctgggcgc ccgagttggg cgcctcccta
      481 ggctaccgag agtaccactc agcacgccgg agcttggcag acatcccagg cccctctacg
      541 cccagctttc tggccgaact tttctgcaag ggggggctgt cgaggctaca cgagctgcag
      601 gtaggaaggg acgcctttcc cgagacagag tgctggggaa actggttttg acagcgtcag
      661 aaaggactga ctagtgcaga ccaaatgtgg gacagccaga gagaacggat gcccatgaaa
      721 taaggaaaag gcgagttgag gctgggggcg gtgtggctac actcgggcag agcccgtccc
      781 gactcttatc agagggcgct gcgaaagcgc cttctcgctg tcctgaggtg tggagatcct
      841 gcagataaag tacaactgcg cgggaggggg aggccggagt gggcagtacc ctccgcctgc
      901 ttgcggctta aagctacatg ggttcctttt cattcactga ggactcgtcc tgagatggac
      961 agtccagaca tggaactttt agagatttct cctcgaccga gatgatcaga gaggtcctga
     1021 atgtctgcct tgcacaaagt tccggttttg cccatcacac tcaaactttc tagggatggg
     1081 aaatgagaga ggaggagttt gcagtatcaa aggcatacac tagttgggca cccgagaaag
     1141 agcagaagct ccctattccc aagcccagtc aacgcccttg gcgtgggcac aggtcaagct
     1201 gaaagtcccc gcccaggtat ccaagtgtcc gctgtgtccg ctcccccagg tgcagggcgc
     1261 cgcgcacttc gggccggtgt ggctagccag ctttgggaca gtgcgcaccg tgtacgtggc
     1321 tgcccctgca ctcgtcgagg agctgctgcg acaggaggga ccccggcccg agcgctgcag
     1381 cttctcgccc tggacggagc accgccgctg ccgccagcgg gcttgcggac tgctcactgc
     1441 gttgagtctt ctctgccccc agaagcccag acgccctgca ccggccctct cctgctgcgg
     1501 gtcccgaaac tatcaatctg ggggcatggt gggaggtcgg ctgtcccact ctaccattgg
     1561 gcatcttggg gttcccatcc cagtctgctt cacccacact caggttgagc cccaacctca
     1621 ctccccgcct acctccttat cctttgaggc ccgaatcctg ggaactgggg gaaccggagg
     1681 aattgggcta gggtacaagg atctggatgg aatgaatgta aggttctgtg actcaagtta
     1741 cccgggaacc ccggcccctg agggcaggaa atgagtaaag aggaaggggg ctggaagaca
     1801 ggcgcaggcc ggtgcaggtt tccgtacccc aagggggcag acgcaatccc tctcctggcc
     1861 accgcagccg aacgcgctcc ttcactgcag ccagtcccgt cgagccgtcc ccaccttccc
     1921 gatgcgcact ctctcctcaa ccctgcaggg aaggcgaaga atggcaaagg ctccgcagtc
     1981 tcctggcccc gctcctcctc cggcctcaag cggccgcccg ctacgccgga accctgaaca
     2041 acgtagtctg cgaccttgtg cggcgtctga ggcgccagcg gggacgtggc acggggccgc
     2101 ccgccctggt tcgggacgtg gcgggggaat tttacaagtt cggactggaa ggtgagtccc
     2161 aggacagagc tgggcaggcg tcgggggcgc cctaccagag cctcccggaa ccctgacggc
     2221 gccccctccc gacgaggcat cgccgcggtt ctgctcggct cgcgcttggg ctgcctggag
     2281 gctcaagtgc cacccgacac ggagaccttc atccgcgctg tgggctcggt gtttgtgtcc
     2341 acgctgttga ccatggcgat gccccactgg ctgcgccacc ttgtgcctgg gccctggggc
     2401 cgcctctgcc gagactggga ccagatgttt gcatttggta aggcacaggt cgaggtggaa
     2461 atgggggaat gtaaagctgt ccaggggtag cgaggtattc acgtgccttc tacccacgca
     2521 gctcagaggc acgtggagcg gcgagaggca gaggcagcca tgaggaacgg aggacagccc
     2581 gagaaggacc tggagtctgg ggcgcacctg acccacttcc tgttccggga agagttgcct
     2641 gcccagtcca tcctgggaaa tgtgacagag ttgctattgg cgggagtgga cacggtgagg
     2701 ttctccctcc gtgctgtgag ccggttccag ggcttagcct ccgcagactc cggctccatt
     2761 tttctgttgc aggggatcca ttatggccac gtagaccagc ttggcttagc accctgtagc
     2821 cccagactct tccataatct gcaccctctg ctgggttctc acacccaaca cctctcttgc
     2881 tttcacatgt ttttcaggtg tccaacacgc tctcttgggc tctgtatgag ctctcccggc
     2941 accccgaagt ccagacagca ctccactcag agatcacagc tgccctgagc cctggctcca
     3001 gtgcctaccc ctcagccact gttctgtccc agctgcccct gctgaaggcg gtggtcaagg
     3061 aagtgctaag gtgaggggga aggagaggag gaacaagagg aaatgccaag gaagggctgg
     3121 ggaagcaact agtggatgga agcagggaga tagcagagaa aaatggccct ctactcctgg
     3181 ccaaaaaggg tttggaagtt ggaaacaatg agaagggggc tgcagcccct agcctcatct
     3241 tgttgtctcc attttgtgct ttgcaaccta gactgtaccc tgtggtacct ggaaattctc
     3301 gtgtcccaga caaagacatt catgtgggtg actatattat ccccaaaaat gtgagtaaag
     3361 cctatgcacc ctttctactg agccattcct cactatcttg ggccccaacc ctgttctcaa
     3421 acactctcct aaaagccctt caaacactcc ccttgacccc tctctaggat atgcctttct
     3481 aggatgtaat ggaacagtgg ggagatcctt ccaaaagtag ccccagaaaa cttccccatc
     3541 acccaccagg acctgccttt gtccctgtct gaatatcctc ttcttcatgc ctgccctatt
     3601 ctgagcccaa actgacaagt ttgttttcct ttgcaccaga cgctggtcac tctgtgtcac
     3661 tatgccactt caagggaccc tgcccagttc ccagagccaa attcttttcg tccagctcgc
     3721 tggctggggg agggtcccac cccccaccca tttgcatctc ttccctttgg ctttggcaag
     3781 cgcagctgta tggggagacg cctggcagag cttgaattgc aaatggcttt ggcccaggtg
     3841 agtgctctag attttatacc ttccccagac tggagagacc ctaaccctct aaagttgtga
     3901 gctctttccc ctgacaagca taggaaatca tataagacct ggtagaatga atcttctgaa
     3961 atatgataag cccattatag gcctggagtg taagtgaggg tattcaaact attttttccc
     4021 taccataatc cctcaccctt attaaccaag aagtccccta ctggccacag gtgccaccca
     4081 atcattgacc attctaacac taataatgca tgccctttac caattggatt accaatgaat
     4141 ccccccatta tagatatctt tcatagtaat gctcaccttc ttccctttcc agatcctaac
     4201 acattttgag gtgcagcctg agccaggtgc ggccccagtt agacccaaga cccggactgt
     4261 cctggtacct gaaaggagca tcaacctaca gtttttggac agatagtccc atggaaagag
     4321 actgtcatca tcaccctttc attcatcata gggataagat tttttgtagg cacaagacca
     4381 aggtatacat cttcccctaa tgcctatctg accaaactgg atagaaccac catagtgaag
     4441 tgtgaggcgg ccctgaccaa tgtgtgaagt atgcacttgg cctgactcag gaagccaggt
     4501 gagaaaacca tggtctctct gcttgcttgg cccttctgat catgtatgca tcccccaagg
     4561 atgaaatcag attttaacta ataatgctgg atggcctgag gaaagattca actgcctctc
     4621 tttttgggct ttcatagtgt tcattgatgc tgctggctaa gcatttatca aagcataagc
     4681 tcagtaactg tgcatctggt ctgtacctgg ttggtccttc gtctttgcat gtaagctctt
     4741 tgagaggaag ggtgaagcct tatttgtttt ttatgtcccc tgccagggcc tgtctctgac
     4801 taggtgtcac catacacatt cttagattga atctgaacca tgtggcagaa gggataagca
     4861 gcttacttag taggctctgt ctaccccctt ccttctttgt cttgccccta ggaaggtgaa
     4921 tctgccctag cctggtttac ggtttcttat aactctcctt tgctctctgg ccactattaa
     4981 gtgggtttgc cccatcactt agttctcagg cagagacatc tttgggcctg tccctgccca
     5041 ggcctctggc tttttatatt gaaaattttt aaatattcac aaattttaga ataaatcaaa
     5101 tattccattc ttgattttga cttatttctc tcatattccc acttcctaca agacctggag
     5161 gcaagactct aaccctccca tctcccacct tggtttctca ggtcctgggg gtgaccccca
     5221 taacaatggg agtctggacg cctggaagag tagtttgtaa cacaaaccca gacatgtttc
     5281 tgtctgtagt gggaacatcc aagtctagtc tggcttcctg taagagatta agggggtggg
     5341 gggtgaaaag taacggcagg ggctaagctg taaaatgggc ccggagctag ggatttgcag
     5401 acatgggcag aggttgctga ctctggtaag gaaagtgctt ttggactgcc aggattgaag
     5461 gaagtcctag attggtcact ttgccctctc tggaaaagtt gttccaagat aatttccttc
     5521 agaggaaggg atacaagcag agaagtggaa tcagacagac agaatgaaag ctgagtgtgg
     5581 gggtggccag aagccctggg gcactgaggc aggataaggg cggtgggcag agggagactg
     5641 tttccctaag tcagcattct ctggcccccc agaggctggg cacagctctc ctcttgtgat
     5701 gtatacagat taactcatct tccatccaaa taaatctctc agcacactgc acagttcctt
     5761 ctgcatccca gattaccctt cccatgtcag gacttgcccc ccttccccta ccgctcaccc
     5821 tattccaatt agctgggtgt agatggagat ttcacttcac acttcttcct cctccacacc
     5881 ttggcctcct ggcctagaca tggctccctg accgcagaaa ctccagtagc caccaggcct
     5941 tttgcagggg catctaatta tgcaagatct acagaggggc agggcagacc caaagcctcg
     6001 tacaaagatc cgaattc
//