LOCUS HQ110882 5184 bp DNA linear MAM 06-JUL-2011
DEFINITION Canis lupus familiaris cyclooxygenase 2 (COX-2) gene, complete cds.
ACCESSION HQ110882
VERSION HQ110882.1
KEYWORDS .
SOURCE Canis lupus familiaris (dog)
ORGANISM Canis lupus familiaris
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
REFERENCE 1 (bases 1 to 5184)
AUTHORS Whiteley,M.H., Bell,J.S. and Rothman,D.A.
TITLE Novel allelic variants in the canine cyclooxgenase-2 (Cox-2)
promoter are associated with renal dysplasia in dogs
JOURNAL PLoS ONE 6 (2), E16684 (2011)
PUBMED 21346820
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 5184)
AUTHORS Whiteley,M.H., Bell,J.S. and Rothman,D.A.
TITLE Direct Submission
JOURNAL Submitted (07-AUG-2010) R & D, DOGenes Inc, 161 Sherin Ave,
Peterborough, ON K9J 7V5, Canada
FEATURES Location/Qualifiers
source 1..5184
/organism="Canis lupus familiaris"
/mol_type="genomic DNA"
/sub_species="familiaris"
/db_xref="taxon:9615"
gene <176..>5177
/gene="COX-2"
mRNA join(<176..227,925..1041,1156..1299,1847..1990,2408..2589,
3112..3195,3296..3542,3829..4115,4486..4633,4768..>5177)
/gene="COX-2"
/product="cyclooxygenase 2"
CDS join(176..227,925..1041,1156..1299,1847..1990,2408..2589,
3112..3195,3296..3542,3829..4115,4486..4633,4768..5177)
/gene="COX-2"
/note="Cox-2"
/codon_start=1
/product="cyclooxygenase 2"
/protein_id="ADO27661.1"
/translation="MLARALVLCAALAVVRAANPCCSHPCQNQGICMSTGFDQYKCDC
TRTGFYGENCSTPEFLTRIKLYLKPTPNTVHYILTHFKGVWNIVNNIPFLRNTIMKYV
LTSRSHLIESPPTYNVNYGYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGKKELPDS
KEIVEKFLLRRKFIPDPQGTNMMFAFFAQHFTHQFFKTDHKRGPAFTKGLGHGVDLNH
VYGETLDRQHKLRLFKDGKMKYQVIDGEVYPPTVKDTQVEMIYPPHVPEHLQFAVGQE
VFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWDDERLFQTSRLILIGETIKIVIEDY
VQHLSGYHFKLKFDPELLFNQQFQYQNRIAAEFNTLYHWHPLLPDTLQIDDQEYNFQQ
FIYNNSILLEHGLTQFVESFSRQIAGRVAGGRNVPAAVQQVAKASIDQSRQMKYQSLN
EYRKRFRLKPYTSFEELTGEKEMAAGLEALYGDIDAMELYPALLVEKPRPDAIFGETM
VEMGAPFSLKGLMGNPICSPDYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTAF
SVQDGQLTKTVTINASSSHSGLDDINPTVLLKERSTEL"
gap 269..838
/estimated_length=570
gap 1370..1754
/estimated_length=385
gap 2126..2310
/estimated_length=185
gap 2619..3038
/estimated_length=420
gap 3564..3801
/estimated_length=238
gap 4179..4422
/estimated_length=244
BASE COUNT 902 a 710 c 646 g 884 t
ORIGIN
1 ttgtcaaaca acttgcagcg agcgtctgga gcacgctcgg gaactccgca cagcgcctgc
61 ctcctccagc gccgcagccc cgagcccagg acgggaacgc ctccgccgcc gcctccgcct
121 ccgccgccgc ctctgccacc gcccgcgctc cgcccgcgcc ccgcccgccg ccgcgatgct
181 ggcccgcgcc ctggtgctct gcgccgccct ggcggtcgtc cgcgcaggtg ggtacctggc
241 tccccgccgc ggggactcct cggctgggnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntt
841 atttatgtaa agttgatcca tacaattcaa tgttaaatga agattaaaga atgaatcatt
901 tactgtcctt actttttttt gtagcaaatc cttgctgttc ccacccatgt caaaaccaag
961 gtatttgtat gagcacagga tttgaccagt ataagtgtga ctgtacccga acaggattct
1021 acggcgaaaa ctgctcaaca cgtaagtgtg cccttggggg tgccctcatt tggactgggg
1081 atatgtccag ttaccaattt catactagtg tctcataatg ggtcctatta atctttccct
1141 cttctgtttt tgcagcggaa tttctgacaa gaataaaatt atacctgaaa cccactccaa
1201 atacagtaca ctacatactt acccacttca agggagtctg gaacattgtc aataacatcc
1261 ccttcctgcg aaatacaatt atgaaatatg tgttgacatg taagtacaag tctctttcta
1321 aggttttcaa tttcctcaaa gaaaaatgtt ctttataaga ctttagattn nnnnnnnnnn
1381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1741 nnnnnnnnnn nnnngtgcca ctttgcacgt tgtacaataa aagtgaacat tgatatgtct
1801 tgcgtatagg aacaaataaa acaatatttt ttttcttaaa tttcagcccg gtcacatttg
1861 attgagagtc caccaactta taatgtgaac tacggctata aaagctggga agccttttct
1921 aacctctcct attataccag agctcttccc cctgtacctg atgactgtcc aacacccatg
1981 ggtgtgaaag gtgagtacgg ggaggcagtt agacatgtat tcattgcaat agggattggg
2041 ttgctaccta gaaaattcag ccctgaacta tcatttattt gttaataaaa gcatattttt
2101 tgcttgagga tatctgtgaa tctcannnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn tttctcctgt aagtgaagaa agccccagac
2341 taaattgaca ttcactgctt gcttgaactt gtaaatgaat tcttatctta gctttctcat
2401 tcttcaggca agaaagagct tcctgattca aaagagattg tggaaaagtt tcttctgcga
2461 agaaagttca ttcctgatcc ccaaggcacc aatatgatgt ttgcattctt tgcccagcac
2521 tttacccatc aatttttcaa gacagatcat aagcgaggac cagctttcac caaaggattg
2581 ggccatgggg taagaaattc aaattatagc aaaagtcann nnnnnnnnnn nnnnnnnnnn
2641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2821 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2941 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3001 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnat gatgaattac attatagaaa
3061 ctttatagaa cttcaacagc aacaaattaa aatttttcca taatcttcca ggtggactta
3121 aatcatgttt atggggaaac tttggataga caacataaac tgcgcctttt caaggatgga
3181 aaaatgaaat atcaggtttg ttccattgga atattaagaa ttgactcaca actaacccat
3241 atttaaaaac ttcccctgat taaaatttaa tgtttgtact actgttgttt cttaggtaat
3301 tgatggagag gtgtatcctc ctaccgtcaa agatactcag gtcgagatga tctacccacc
3361 tcatgttcct gaacacctgc agtttgctgt gggccaggag gtctttggtc tggtgcctgg
3421 tctgatgatg tatgccacca tttggctgcg ggagcataac agagtgtgtg atgtgcttaa
3481 acaggagcac ccagaatggg atgatgagcg gttattccag acgagcaggc taatactgat
3541 aggtaagcaa gaagagaaaa taannnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3781 nnnnnnnnnn nnnnnnnnnn natttttttg ttgttgttgt gtaaatagga gaaaccatta
3841 agattgtgat tgaagactat gtacaacact tgagtggcta tcacttcaag ctgaagtttg
3901 acccagagct gcttttcaac caacaattcc agtaccaaaa ccgcattgct gctgagttta
3961 acacactcta ccactggcat cccctcctgc ctgacacctt gcaaatagat gaccaggagt
4021 acaatttcca acagtttatc tacaacaact ctatattatt ggaacatggc cttacccagt
4081 ttgtggaatc attcagcagg caaattgctg gcagggtaag ccttgttatt gaaaaaacaa
4141 aggactaatc agaatttctg ccaccaaagt gatctttcnn nnnnnnnnnn nnnnnnnnnn
4201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
4261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
4321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
4381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnaaagtaga gatcatcata
4441 aagatgccta agaccttatt ctacaattta attcatttcc cataggttgc cggtggcagg
4501 aatgttccag ctgcagtaca acaagtagca aaagcttcga ttgaccagag cagacagatg
4561 aaataccagt ctcttaatga gtatcgcaaa cgctttaggc tgaagcccta tacatcattc
4621 gaagaactta caggtgagag aaacttctta agaatcaagg gtcaaatgga aacaagttga
4681 aagggaattg agcaaagggt taaaactttt ttttttggta aagtttttta tacattagtt
4741 gaatatctgt ttttgtcacc ttcacaggag agaaggaaat ggctgcgggg ttggaggccc
4801 tttatggtga tattgatgcc atggagctgt atcctgccct cttggtagaa aagcctcgtc
4861 cagatgccat ctttggtgag accatggtag aaatgggagc accattctcc ttgaaaggac
4921 ttatgggtaa tcccatctgt tcacctgact actggaagcc tagcaccttt ggtggagaag
4981 taggctttaa aatcatcaac actgcctcaa tccagtctct catctgcaat aacgtgaagg
5041 gctgtccatt cactgcattc tctgttcaag acggacaact caccaaaaca gtcaccatta
5101 atgcaagctc ttcgcactcc ggtctagatg acatcaatcc cacagtccta ctgaaagaac
5161 ggtcaactga actatagaag cctg
//