LOCUS       AF252539                8406 bp    DNA     linear   INV 06-APR-2001
DEFINITION  Leishmania mexicana amazonensis extrachromosomal element ICAM-like
            surface protein and ribonucleotide reductase small subunit M2
            genes, complete cds.
ACCESSION   AF252539
VERSION     AF252539.1
KEYWORDS    .
SOURCE      Leishmania amazonensis
  ORGANISM  Leishmania amazonensis
            Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
            Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
REFERENCE   1  (bases 1 to 8406)
  AUTHORS   Chiang,S.C., Ali,V., Huang,A.L., Chu,K.Y. and Tone Lee,S.
  TITLE     Molecular, cellular and functional characterizations of a novel
            ICAM-like molecule of the immunoglobulin superfamily from
            Leishmania mexicana amazonensis
  JOURNAL   Mol. Biochem. Parasitol. 112 (2), 263-275 (2001)
   PUBMED   11223133
REFERENCE   2  (bases 1 to 8406)
  AUTHORS   Lee,S.T. and Chiang,S.-C.
  TITLE     Extrachromosomal amplified DNA, clone pBHu8.5
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 8406)
  AUTHORS   Lee,S.T. and Chiang,S.-C.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-APR-2000) Infectious Disease, Institute of Biomedical
            Sciences, Taipei 115, Taiwan
FEATURES             Location/Qualifiers
     source          1..8406
                     /organism="Leishmania amazonensis"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:5659"
                     /clone="pBHu8.5"
                     /note="hydroxyurea-resistant strain derived from LV-78;
                     cloned from extrachromosomal amplified circular DNA"
     mRNA            <699..>1847
                     /product="ICAM-like surface protein"
     CDS             699..1847
                     /codon_start=1
                     /product="ICAM-like surface protein"
                     /protein_id="AAF72617.1"
                     /translation="MAQQRGKRAAPSKAAVANASASAPDPPPFFSMGPATFTDAIVIT
                     KVISVVLPLRHLRDRNILHTTLLKKLLHRPYEASAEDLAQQQLSQQETDDGGKHGRGA
                     HSALDNLAAPTSSSSSTPYVIVHIKSAEIHADTARQVNPRGDVQVNVMVTLVAARLQH
                     GICAGVSEASPFTSCMQVRVPTVAVSAAVAARGSTDDAATLLLRDASEAGTDNVSQEG
                     VKDAKAEPSGGDAALDASVSATTTAAAAKRSCCTGVPEDQQLRVTARCLEDEPIVPGQ
                     AVLLISEPAAMRCMGIRPPRAAPGPFYLTETTQPSAQFSSGEAEGGPEARPKKRARKS
                     RASAGGTGGATPARRIVSIECAIPKREEDGEGGAAAGTRKGPRKRPHT"
     mRNA            <2930..>3967
                     /product="ribonucleotide reductase small subunit M2"
     CDS             2930..3967
                     /codon_start=1
                     /product="ribonucleotide reductase small subunit M2"
                     /protein_id="AAF72618.1"
                     /translation="MKPVAAGAEVLPADKVAQGTNAEEEPLQQENPFRYVLFPIQYHD
                     IWRKYKEQESCIWTVEEIDLGNDMKDWATLNDGERHFIKHVLAFFAGSDGIVIENLAQ
                     RFMSDVKVPEARAFYGFQLMMENIHSETYSVLLDTYITDSEEKLRLLHAIQTIPCIQK
                     KAEWAVRWIGSSASFQERLIGFAAVEGIFFSGSFCALFWLKKRGLMPGLTFSNELISR
                     DEGLHTDFACLLYNSHIKHKLPRERVLEIIVDAVNIEREFICDALPVRLIGMNAELMA
                     QYIEFVADRLLVSLGEEKHYRSTQPFDFMEMISLQGKTNFFEKRVGEYQKAGVMSTEG
                     TSKKFSLSEDF"
BASE COUNT         1642 a         2499 c         2456 g         1762 t
ORIGIN      
        1 gatatcgaag gggcgttgca tgggacgcgc acgtccagca gctctcaccg ccgtcaccgc
       61 tcttgtcttc gtcgtgcgcg ctgacgctcc actttgtcct tttcaatgat gccttcatcg
      121 aacgtttttt tctttcgttg ctactcggac aacgaagagg gcacgctgtc tctgcctaga
      181 tgcgcgtcgg cgccagcgcg cggcggtgtc ctgagtgtcc ttccttctct cttctgcctg
      241 cgtgcattac gtgcttttct tctccttctc tctctctctc tctctcgcac tcgctccagc
      301 acttcgcctg tgcacatcct cttcagctaa gcagtgccag gcacaccttg cgtcccgcgt
      361 tgtgcacaga cgcactcacg tgcacgcata tatgtgtata tgctaacgca cgcaaacctg
      421 tttagcgagc tacaccgaca cacacacaca ccgacacaca cacaccgaca cacgcacacc
      481 gacacacaca caccgacaca cacacacgca caccgacaca cacacaccga cacacacaca
      541 cacacaccga cacacacaca ccgacacaca cacacgcaca ccgacacaca cacaccgaca
      601 cacacacaca ccgacacaca cacaccccga cacacacaca ccgacacaca cacacaccga
      661 cacacacaca caccgacaca cacacgcagg caagtgtaat ggcgcagcag cgggggaaga
      721 gggcagcgcc gtcaaaggca gccgtggcga atgcgtctgc aagtgcgcct gacccgccgc
      781 cgttcttttc catggggccc gccaccttca ccgacgccat cgtcatcacc aaggtcattt
      841 cggtcgtgct gccattgcgc cacttgcgtg accgcaacat cctgcatacg acgcttctga
      901 agaagttgct ccatcgtccc tacgaggcat ctgcagagga cctcgcccaa cagcagctct
      961 cgcaacagga gaccgacgat ggcggcaagc atggccgcgg tgcacacagc gcgctcgaca
     1021 accttgcggc acccacgtcg tcatcttcgt cgacacccta cgtgattgtc cacatcaagt
     1081 ccgctgagat tcacgccgac acggctcgcc aggtaaaccc gcgcggcgat gtgcaggtga
     1141 acgtgatggt gaccctcgtc gcagctcgcc tccagcacgg gatctgcgcc ggtgtctcgg
     1201 aggcgtcgcc gttcacgtcg tgcatgcaag tgcgggtacc gacagtggcc gtgtccgccg
     1261 cggtggcagc caggggcagt acggacgatg cggcaacact gttactcagg gatgcttcgg
     1321 aggcaggcac cgataatgtg tcgcaggaag gggtcaaaga cgcgaaggca gagccgagcg
     1381 gtggcgatgc agcgctcgat gcctccgtgt cagccaccac gacggctgct gccgcgaagc
     1441 gcagctgctg cactggcgtc cctgaggatc aacagctgcg cgtgacagcg cggtgcctag
     1501 aggacgagcc gatcgtgcca ggtcaagcag tcttgctcat ctccgagccg gccgctatgc
     1561 gctgcatggg catccggccg ccgcgtgcag caccaggccc gttttaccta acagaaacga
     1621 cgcaaccgtc ggctcagttc tccagcgggg aggcagaggg cgggcctgag gcgaggccga
     1681 agaagcgcgc acgcaagtca cgcgcgtccg ccggcggcac aggtggtgct acaccagcgc
     1741 gtcgtatcgt gtccatcgag tgcgccatcc cgaaaagaga ggaggatggg gagggcggcg
     1801 cagcggcagg cacccgcaag ggcccgcgta agcgaccaca cacttaatca aagtcattgt
     1861 gggtgacggg gccaaaggga tggagagcag gcgcgcagag ggttgagcga aagggaaagt
     1921 ggggaaggag gtgaggggtg gtggccaacn acatccccat ggcttntctg tgctgctttt
     1981 gcgctcncta ccgcgacgca tttccctccg cgcatgtnta ctctgtctca cgctcggcca
     2041 cctcccgatc tcttnccctc atcgctggcc atgcgtncat ctaacaaaat ctacgcccgc
     2101 acgttggcgg ttgtgcacgt gagggcatgt cttgcncttc gccgacccct cccccgtacc
     2161 cctctttctc cgtcgctact ttacagctcg acttaaaaaa cgtgcgaatg gcgcatgcac
     2221 gaaggtaaac tctgaagcaa gcaccgatac aggcgatgga gacgtggcaa tgtcctctgc
     2281 gtgactgttt gtgngnancg natacggngc actgcatcca cacccatcac agatcgcttt
     2341 tcctcgccct naagcactcg cggggcgtcg atgcccttct ttgatcgtgg tgctgcactt
     2401 ctcactcaca tgtgggtcga catccatcat gctatnttgt gtgatggcat ctgcntntca
     2461 cgtgcacntn cncntgcacg cccatcatcg cgcttcccat tgtcttttct cctcgcttct
     2521 cgtctctctc acatacncat cctcattcac agtcgcatgc gaaaccctct ccccccccat
     2581 acacacatac actcacccaa gcagccatct ctcgctctcg ctctccctca ttgcaacccc
     2641 cgttgtatct cgatagacgc gcacacacag gctcccctga ccactcctcc tcatctccac
     2701 ttcccataga aacgcataca cccatttttc tgcacacgcg cttagatctt ctccagactc
     2761 ctctctcccc tagagcctgt gcgatctccg actcatcatc atgtcgtcta ccgaagccaa
     2821 cctgcagcct gccgcgaagc gtccgcgtga ggaggacgtg gaggtggaag ttgcttgcac
     2881 gtcgaccgat ggcgcggcca ccgatgctgc caagacggag gatcacgtca tgaaaccggt
     2941 tgcggctggc gccgaggtgc tgccggcgga caaggttgcc caggggacga acgccgagga
     3001 ggagccgctg cagcaggaga acccgttccg ctacgtcctc ttcccaatcc agtaccatga
     3061 catctggcgc aagtacaagg agcaggagag ctgcatctgg acggtggagg agatcgacct
     3121 gggcaacgac atgaaggact gggcaacgct gaacgacggt gagcggcact tcatcaagca
     3181 tgtgcttgcc ttcttcgccg gcagcgacgg catagtcatc gagaatcttg cgcagcgctt
     3241 catgagcgac gtgaaggtgc cagaggcgcg cgcgttctac gggttccagc tgatgatgga
     3301 gaacatccac tcggagacgt actctgtgct gctggacacg tacatcacgg acagcgagga
     3361 gaagctgcgg ctgctgcacg cgatacagac gatcccgtgc atccagaaga aggcggagtg
     3421 ggccgtgcgg tggatcggga gcagcgcgag ctttcaggag cggctgatcg gctttgccgc
     3481 ggtggagggc attttctttt ccgggtcgtt ctgcgcgctg ttctggctga agaagcgcgg
     3541 tctgatgcca gggctgacgt tcagcaacga gctcatctcg cgcgacgagg gtctacacac
     3601 ggacttcgca tgcctgctgt acaactcgca catcaagcac aagctgccgc gcgagcgcgt
     3661 gctggagatc atcgtggatg cggtgaacat cgagcgtgag ttcatctgcg acgcgctgcc
     3721 ggtgcggctg attggcatga acgcggagct gatggcgcag tacatcgagt tcgtcgcgga
     3781 ccggctgctg gtgtcgctcg gcgaggagaa gcactaccgc tcgacgcagc cgttcgactt
     3841 catggagatg atctcgctgc agggcaaaac gaacttcttc gagaagaggg tgggggagta
     3901 ccagaaggcc ggcgtgatga gcacggaggg cacgtcgaag aagttctccc tctcggagga
     3961 cttctaaaca ggagcgctgc ctgacctctg gccgccggat tatccgatac tgcgcgtttt
     4021 gcgcacgcgt tgtcggtgtg tttgggggag gggaaggagg gaagatgagg agaagcagca
     4081 gcacctcgta gccgcgcaca ttcatccgtg aatccgtgag gcgctgcaga tggggacacg
     4141 aacaccatca ctagcattgc agcggcacca ccactgtgtg atgccatttc gtangcgcgt
     4201 atgtgttggt gcgcccaggg ctggcccgac gctgatctaa cccttcagct ctacacctcg
     4261 actcgattcg tgggaggtgt ctctcgcacc cccagaagcc ctctatatag gccataggaa
     4321 tgcggtgagc acacaacagg gtgatgcctg tctcggaaga caagaggaga gcacgcaaca
     4381 gcaaaataac gcgaatacga aaacagcgac aagggaggcg ctggctgctt cgagagatgg
     4441 cgaggtttgt tgtacgtgcg tgcgtgtgtg tgtgcctgcg taagacgtgg ttcattgctt
     4501 ctgcttgctg tatggcagcc gtgttgcgtt cccgtctctc catcccggtg caggtgagtg
     4561 ctgggcgtct tcagctgatg ctgctctacc tcgttgggtc tctcttgctc ttcatctcat
     4621 gtgtctcttc catctcttgg gctcgcgtac tctcatctct gaaagctgcg taggctcacg
     4681 agccttcccg gtggcgcgaa gatgccgcat gggagccctc acgatgggtt tgatggtcgc
     4741 aagcgcgagg cgtgcttgct gctgcgacga ggagacaaga gagagcgggg aagagggcta
     4801 atgaattgac ccgcagtatg cgtactctac cggcatgcnn gcatacagtg acgcncncnt
     4861 cgtgatggcg gatacatgca cacacacaca cacacacaca cacacacaca cacacatact
     4921 gcacacaacg acgcttaagt gcgcggcgct attctcttct tgttttaacg atttctcgct
     4981 cttgctctat ttttctttgt tccttattct ctctctctgt gtgtgcgtgt gcgtggaagt
     5041 cgcacgcgtg caacacacgt ttggtttcac gatgtcgtgg atctttgtct atttcggttt
     5101 ctcttttacc tgctcggcag gttcttggag gtgatggcgt gcgtctcgcc ggaagtgtgt
     5161 gtgcgtgtct gctcaacgca gaccgcggct gaccgccgct ccatgcgtga gtgcgcgagt
     5221 gagtgagtga ttgagtgaga gagaggaaga gcggtggaat ccagcgcggc agcggaggag
     5281 ggcagtcgca gagagagaca tggacacaca cacacacacg ttagggacgc accgcgtgct
     5341 cgaaaatgcg ttctgctgca cgaggggggt gtggcggggg tgggtggggc ttgggaagcg
     5401 gagaagaggt gtcggtgggt gccgttgctg gtgccattgt agcaggcgaa ggagcgacag
     5461 agaaagggag gaggcgaagg agaaggggcc caccacgatg gcttcttctc gaagcgtaaa
     5521 ctcgccgacg ctattctctc ttcttctgtt tccccacctt ccaactcccg tgaccacatg
     5581 cgcgtgcggc acgcgctgat gagcgctcat tctttttttt ttcgctttgg ttgggcttgt
     5641 ttgcgtgtac gtgatggttt cctgccgggt ttgtgcattg cgtcagggca ggtagccaag
     5701 cgaaggggga gcgaactctc tctctctccc gtatttctaa tctttttatt tgtggctctt
     5761 ctcttctctc tcttctccac cgcctcactt tgtttttctt cggtgtcgaa gtggtggtgg
     5821 tgatgatggc cgaaggggga tggatgttgg acaggaggag gggagaggtc ggcggggaag
     5881 tatgcgatag atacagaaag aacgcactga agtggatcta tctgagagag actacaatgg
     5941 aggtgtggag aagatgcggt ggtgagtgct gcggagatgg gggctgcgca tgccctccct
     6001 catgttttgc ttgtgtcgct tgcagtgctc cgtcgcgcgc gactgcggct ttcactgact
     6061 accgcttctc tctgctgtct ctcccgccat cttcacttgt acaaaaaagc cctgcgatag
     6121 tgacgccatc caatcaaaac gcgctcaggc atcgacacac acacacacgc gcgccaacag
     6181 accggcggac tgttgctgga gcggcctgcg actgtgaagg cgcttgtgcc gtccgcacga
     6241 tgagccgagc gtcccactcg cncgtacccc acccggtgct cgctgcctgc tggtggggag
     6301 cctttatgcg accctgtggg ggtgngnccg gtcggggngn gnggggggca caatgggcgg
     6361 ggcgcgaggc ggcgtgcggg gcgggcggtg tgccgacgct gaggcggagg ccgcgccccg
     6421 gcgactgtgg cggcgcatca ctgggaggcg tgtgtctccc gctgcctcgt gccgcgcgat
     6481 gacggtcctg tgttgccggg nnggggtggg gagcgggtgg ctgggctcat gctccacggc
     6541 ggcgaatggc cgcgctgaag ggaaggagga gacacaaatt tgcgtgcctc actgctcttg
     6601 tccagtttct cgttcccttt tccaacgcga gacggtggct gcccacccat ctccgccccc
     6661 gctggtacac gacgtcgaaa ggcgtgcgtc ggtccagtgc gctctgctgt tggtttgtgg
     6721 tgggtttgtg cgttgcactg ttttttctcg tgctttcttg gctgtgtttc tatggtctgc
     6781 tgnacgcgac gcctctcccc cgaatctgcg gacggcgcac aggcaacggc acacgccaag
     6841 aacaatgaac agaaaaaaaa cgagaagaaa cagagaagac ccagcacggt gcttcatggg
     6901 gtgnacatgc ttcagactcc atgcgcgtga cgccgctgtc ttctggtaac cgcgatttgt
     6961 ttcgcatcgt caggcactct ctgttgagag gacccaccct cccctctttc caatcttgaa
     7021 atcgtctcac ctgcgccctt ttccctccac acactcttca tctctgcgag ctcaacacga
     7081 aacccgcgca tgctcacgcc aacgtgcacg cgtcgtgcgg cacgcaccgt gagcaaccgc
     7141 agcgcaaatc cagaccctcc tggagggaca acggcacgcg ngttttacat agcgcgagag
     7201 agaaaaaaaa acgaaatcac ggcaanacag tcgcactctt gtacaggcac gngcagacgn
     7261 gtgngcatgc acccgcgcta ccggcggctt gtagcacatc gtgggagcaa ccaangcacc
     7321 cacgcgccag ggcaagtgga actgctcgac cgcagtgcga gtcactagca gtttctcggt
     7381 acgcggggca aggtctgtaa gtgtgngtgt gcaggtgagc gtgtggcagg aggcacaaaa
     7441 tgagtcgaca tggctacggc aactactagg atgcagacaa gggctctggt ggatacagcc
     7501 gaaacgcgcg tacaggccgt ttggaccatt ccgcctcgtc tccacgctga tggtggccgt
     7561 cgccattggc ttcatcgcct tcggcctcgc gtgcgcagta atgtntgtcg ccgaggtcgc
     7621 ggaggagcac ccgtcgcgca ccaagtgggt tcttcgtgcc catcatcttc aactttgtcg
     7681 tgcacncgtc catcttgtcg tagatcagat gagctggtgg cgatcgttgc tcagcctctt
     7741 ggtgaatgtg ctgtncttgc ggctgctgcg caccttcccg tttgtgccgg gcatgaacag
     7801 cccgctggtg ctggcgacga tgctggcggt gttgctggag agcgccatgt ggtactggtt
     7861 cgcactgcga cttatgtact acacgtcatg ctgttggttt ttggcttcat cctgattgtg
     7921 gctcgtgccg attgggcttc tgtcgtcgtg tgtcatagaa gaggatcggt tgccgggcgg
     7981 cggtggcgca ggggcgatgt acagttgtcg cggctccgca tccggcggcg gctcatccgc
     8041 gccgacgcaa tggcgggtgg gcgtcgaggc gcaccattct caatcgtcta gcggacctga
     8101 tcaacaacac ctagacacgc agaattggtg gcaaacacac acacacacac acacgcttcg
     8161 gttgtccaca acttcccctc ttctccactg ctgtgttgct ctcgctgact cggttaacat
     8221 gtcgttaacc tgattggcat ttcacggcat ttttgcctac attatgtgtg tgtgcacata
     8281 tatatatata tatatatata tatatattag atgatgtctg cgcgcgatca ggcgcgtttt
     8341 ctttctcctc ccccgaaatc gcgctgggcg gaaacgatag tagcccgcct ttatccatat
     8401 gatatc
//