LOCUS SIU02556.1 833 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
CONSERVED MEMBRANE PROTEIN [FIRST PART] protein.
ACCESSION LT708304-3970
PROTEIN_ID SIU02556.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="eccc2"
/locus_tag="BQ2027_MB3924C"
/note="Mb3924c, -, len: 833 aa. Equivalent to 5' end of
Rv3894c, len: 1396 aa, from Mycobacterium tuberculosis
strain H37Rv, (99.9% identity in 771 aa overlap). Possible
conserved membrane protein (possible transmembrane
segments from aa ~37-85), similar to Q9CD30|ML2535
HYPOTHETICAL PROTEIN from Mycobacterium leprae (1329 aa),
FASTA scores: opt: 652, E(): 2.2e-30, (27.85% identity in
1425 aa overlap); Q9CDD7|ML0052 HYPOTHETICAL PROTEIN from
Mycobacterium leprae (597 aa), FASTA scores: opt: 537,
E(): 6.6e-24, (27.5% identity in 585 aa overlap)
(similarity only with C-terminal end);
Q9Z5I2|ML1543|MLCB596.28 POSSIBLE SPOIIIE-FAMILY MEMBRANE
PROTEIN from Mycobacterium leprae (1345 aa), FASTA scores:
opt: 523, E(): 8.6e-23, (31.65% identity in 1412 aa
overlap). Also similar to various proteins e.g.
O86653|SC3C3.20c ATP/GTP BINDING PROTEIN from Streptomyces
coelicolor (1321 aa), FASTA scores: opt: 973, E():
2.8e-49, (28.1% identity in 1409 aa); Q9L0T6|SCD35.15c
PUTATIVE CELL DIVISION-RELATED PROTEIN from Streptomyces
coelicolor(1525 aa), FASTA scores: opt: 524, E(): 8.3e-23,
(24.95% identity in 1450 aa overlap); Q9KE81|BH0975
HYPOTHETICAL PROTEIN from Bacillus halodurans (1489 aa),
FASTA scores: opt: 444, E(): 4.1e-18, (22.5% identity in
1346 aa overlap); etc. Also similar to AAK46103|MT1833
FTSK/SPOIIIE FAMILY PROTEIN from Mycobacterium
tuberculosis strain CDC1551 (1391 aa), FASTA scores: opt:
769, E(): 2.9e-37, (30.6% identity in 1434 aa overlap);
and other hypothetical proteins from Mycobacterium
tuberculosis e.g. O53689|Rv0284|MTV035.12 (1330 aa), FASTA
scores: opt: 634, E(): 2.5e-29, (28.2% identity in 1443 aa
overlap); O06264|Rv3447c|MTCY77.19c (1236 aa), FASTA
scores: opt: 632, E(): 3.1e-29, (28.75% identity in 1391
aa overlap); O69736|R3871|MTV027.06 (591 aa), FASTA
scores: opt: 588, E(): 6.6e-27, (27.75% identity in 605 aa
overlap) (similarity only with C-terminal end); etc.
Contains two possible (PS00017) ATP/GTP-binding sites
(P-loop) in central portion.
REMARK-M.bovis-M.tuberculosis: In Mycobacterium
tuberculosis, Rv3894c exists as a single gene. In
Mycobacterium bovis, a frameshift due to a single base
insertion (*-c), splits Rv3894c into 2 parts, Mb3923c and
Mb3924c."
/db_xref="GOA:A0A1R3Y5T2"
/db_xref="InterPro:IPR002543"
/db_xref="InterPro:IPR023836"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:A0A1R3Y5T2"
BEGIN
1 MSKKAFPINR VNIDPPKPVR VAPNPPIALP EREPRNIWVM IGVPALIVAL IGTIVMLYVS
61 GVRSLATGFF PLMGIGAFSM LAFSGRFGRA RKITWGELEK GRRRYLRDLD TNRDEIQTAV
121 CAQREWQNAV HSDPPGLGAI IGGPRMWERG RGDVDFLEVR VGTGVQHAPD SVLSVTWPDI
181 SSDEELEPVT GQALRDFILE QRKIRDIAKV VNLRSAPGFS FVSEDLDRVR SLMRSVLCSL
241 AVFHNPRDVK LMVVTRNPEV WAWMVWLPHN LHDELFDACG WRRLIFATPE ELEAALGAEL
301 HMKGKRGAWT PPTVASPTAM GSALETGQVG VDLGPHLVIV DDNTGSPDAW ESVVGQVGKA
361 GLTVLRIASR VGTGVGFAED QVFEMAQRHG AATAVKAGRD GADADDDQRP APLLRARGTF
421 FAHADQLSIH RAYRYARAMA RWSPTSRSEV TDSTSGAAEL LRSLGISDPR ELDVDRLWAE
481 RRGRGDDRWC EIPVGAKPNG ELQNIILRAK DFGGFGFHSV VIGTSGSGKS ELFLSLVYGI
541 ALTHSPETFN VIFVDMKFES AAQDILGIPH VVAALSNLGK DERHLAERMR RVIDGEIKQR
601 YELFKSVGAR DANDYEEIRL AGRDLPPVPV LLVIVDEYLE LFANHKKWID LIIHIGQEGR
661 GANVFFMLGG QRLDLSSLQK VKSNIAFRIA LRAESGDDSR EVIGSDAAYH LPSKENGFAL
721 LKVGPRDLEP FRCFYLSAPF VVPKKKEVAR TIDMTLTQPR LYDWQYQPLD ARRRRGIGDR
781 RGRRCGTRRI PLLRRRFQEE EDRRRAAGVA IQRAAPIAAP AVVGAAGRPR AGR
//