LOCUS       SIU02537.1                95 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 6 kda
            early secretory antigenic target esxa (esat-6) protein.
ACCESSION   LT708304-3951
PROTEIN_ID  SIU02537.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="esxA"
                     /locus_tag="BQ2027_MB3905"
                     /standard_name="esat-6"
                     /note="Mb3905, esxA, len: 95 aa. Equivalent to Rv3875,
                     len: 95 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 95 aa overlap). esxA, Early Secretory
                     Antigenic Target (see citations below), identical to
                     Q57165|O84901|ESAT6 EARLY SECRETORY ANTIGENIC TARGET from
                     Mycobacterium bovis (94 aa), FASTA scores: opt: 596, E():
                     4.6e-33, (100.0% identity in 94 aa overlap). Also similar
                     to Q50206|ESA6_MYCLE|ESAT6|ESX|L45|ML0049|MLCB628.12c 6
                     KDA EARLY SECRETORY ANTIGENIC TARGET HOMOLOG (ESAT-6-LIKE
                     PROTEIN) (L-ESAT) from Mycobacterium leprae (95 aa), FASTA
                     scores: opt: 236, E(): 3.3e-09, (36.25% identity in 91 aa
                     overlap); and weak similarity with others proteins
                     ESAT-like from Mycobacterium leprae. Also some similarity
                     with O53266|ES69_MYCTU|Rv3019c|MT3104|MTV012.33c PUTATIVE
                     SECRETED ESAT-6 LIKE PROTEIN 9 from Mycobacterium
                     tuberculosis (96 aa), FASTA scores: opt: 131, E(): 0.03,
                     (26.15% identity in 88 aa overlap); and other ESAT-like
                     protein. Contains probable coiled-coil from 56 to 92 aa.
                     BELONGS TO THE ESAT6 FAMILY. Protein product from Mb3905
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3905 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A565"
                     /db_xref="InterPro:IPR010310"
                     /db_xref="InterPro:IPR036689"
                     /db_xref="UniProtKB/Swiss-Prot:P0A565"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTEQQWNFAG IEAAASAIQG NVTSIHSLLD EGKQSLTKLA AAWGGSGSEA YQGVQQKWDA
       61 TATELNNALQ NLARTISEAG QAMASTEGNV TGMFA
//