LOCUS       SIU02532.1               747 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 esx
            conserved component eccca1. esx-1 type vii secretion system
            protein. possible transmembrane protein. protein.
ACCESSION   LT708304-3946
PROTEIN_ID  SIU02532.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="eccca1"
                     /locus_tag="BQ2027_MB3900"
                     /note="Mb3900, -, len: 747 aa. Equivalent to Rv3870, len:
                     747 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 747 aa overlap). Possible conserved
                     membrane protein, equivalent to O33087|ML0053|MLCB628.16c
                     PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (744
                     aa), FASTA scores: opt: 4333, E(): 0, (85.4% identity in
                     746 aa overlap); and similar to N-terminal end of others
                     e.g. Q9CD30|ML2535 HYPOTHETICAL PROTEIN from Mycobacterium
                     leprae (1329 aa), FASTA scores: opt: 1003, E(): 1e-52,
                     (33.65% identity in 725 aa overlap); O86653|SC3C3.20c
                     ATP/GTP BINDING PROTEIN from Streptomyces coelicolor (1321
                     aa), FASTA scores: opt: 1078, E(): 3e-57, (35.4% identity
                     in 774 aa overlap); P71068|YUKA YUKA PROTEIN from Bacillus
                     subtilis (1207 aa) FASTA scores: opt: 529, E(): 4.3e-24,
                     (26.1% identity in 636 aa overlap); Q9KE81|BH0975
                     HYPOTHETICAL PROTEIN from Bacillus halodurans (1489 aa),
                     FASTA scores: opt: 455, E(): 1.5e-19, (27.1% identity in
                     734 aa overlap); etc. Also similar to N-terminal end of
                     hypothetical proteins from Mycobacterium tuberculosis e.g.
                     O53689|Rv0284|MTV035.12 (1330 aa), FASTA scores: opt: 982,
                     E(): 1.9e-51, (33.8% identity in 719 aa overlap);
                     O06264|Rv3447c|MTCY77.19c (1236 aa), FASTA scores: opt:
                     761, E(): 4.1e-38, (38.2% identity in 746 aa overlap);
                     O53935|Rv1784|MTV049.06 (932 aa), FASTA scores: opt: 547,
                     E(): 2.8e-25, (36.25% identity in 276 aa overlap).
                     Contains PS00017 ATP/GTP-binding site motif A (P-loop).
                     Note some similarity (with hypothetical proteins from
                     Mycobacterium tuberculosis and P71068|YUKA) continues in
                     downstream ORF MTV027.06. Protein product from Mb3900
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3900 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y5H3"
                     /db_xref="InterPro:IPR002543"
                     /db_xref="InterPro:IPR023836"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y5H3"
BEGIN
        1 MTTKKFTPTI TRGPRLTPGE ISLTPPDDLG IDIPPSGVQK ILPYVMGGAM LGMIAIMVAG
       61 GTRQLSPYML MMPLMMIVMM VGGLAGSTGG GGKKVPEINA DRKEYLRYLA GLRTRVTSSA
      121 TSQVAFFSYH APHPEDLLSI VGTQRQWSRP ANADFYAATR IGIGDQPAVD RLLKPAVGGE
      181 LAAASAAPQP FLEPVSHMWV VKFLRTHGLI HDCPKLLQLR TFPTIAIGGD LAGAAGLMTA
      241 MICHLAVFHP PDLLQIRVLT EEPDDPDWSW LKWLPHVQHQ TETDAAGSTR LIFTRQEGLS
      301 DLAARGPHAP DSLPGGPYVV VVDLTGGKAG FPPDGRAGVT VITLGNHRGS AYRIRVHEDG
      361 TADDRLPNQS FRQVTSVTDR MSPQQASRIA RKLAGWSITG TILDKTSRVQ KKVATDWHQL
      421 VGAQSVEEIT PSRWRMYTDT DRDRLKIPFG HELKTGNVMY LDIKEGAEFG AGPHGMLIGT
      481 TGSGKSEFLR TLILSLVAMT HPDQVNLLLT DFKGGSTFLG MEKLPHTAAV VTNMAEEAEL
      541 VSRMGEVLTG ELDRRQSILR QAGMKVGAAG ALSGVAEYEK YRERGADLPP LPTLFVVVDE
      601 FAELLQSHPD FIGLFDRICR VGRSLRVHLL LATQSLQTGG VRIDKLEPNL TYRIALRTTS
      661 SHESKAVIGT PEAQYITNKE SGVGFLRVGM EDPVKFSTFY ISGPYMPPAA GVETNGEAGG
      721 PGQQTTRQAA RIHRFTAAPV LEEAPTP
//