LOCUS       SIU02531.1               480 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 esx
            conserved component eccb1. esx-1 type vii secretion system
            protein. possible membrane protein. protein.
ACCESSION   LT708304-3945
PROTEIN_ID  SIU02531.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="eccb1"
                     /locus_tag="BQ2027_MB3899"
                     /note="Mb3899, -, len: 480 aa. Equivalent to Rv3869, len:
                     480 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 480 aa overlap). Possible conserved
                     membrane protein (has hydrophobic stretch near
                     N-terminus), equivalent to O33088|ML0054|MLCB628.17c
                     PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (481
                     aa), FASTA scores: opt: 2489, E(): 8.3e-136, (75.75%
                     identity in 478 aa overlap); and similar to others e.g.
                     Q9Z5I3|ML1544|MLCB596.27 CONSERVED MEMBRANE PROTEIN from
                     Mycobacterium leprae (506 aa), FASTA scores: opt: 739,
                     E(): 3.9e-35, (33.65% identity in 490 aa overlap). Also
                     similar to hypothetical proteins from Mycobacterium
                     tuberculosis e.g. O05449|Rv3895c|MTCY15F10.17 (495 aa),
                     FASTA scores: opt: 795, E(): 2.3e-38, (35.8% identity in
                     486 aa overlap); O53933|Rv1782|MTV049.04 (506 aa), FASTA
                     scores: opt: 763, E(): 1.6e-36, (34.7% identity in 490 aa
                     overlap); O06317|Rv3450c|MTCY13E12.03c (470 aa) FASTA
                     scores: opt: 717, E(): 6.7e-34, (32.55% identity in 479 aa
                     overlap); etc. Protein product from Mb3899 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb3899 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y5K0"
                     /db_xref="InterPro:IPR007795"
                     /db_xref="InterPro:IPR042485"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y5K0"
BEGIN
        1 MGLRLTTKVQ VSGWRFLLRR LEHAIVRRDT RMFDDPLQFY SRSIALGIVV AVLILAGAAL
       61 LAYFKPQGKL GGTSLFTDRA TNQLYVLLSG QLHPVYNLTS ARLVLGNPAN PATVKSSELS
      121 KLPMGQTVGI PGAPYATPVS AGSTSIWTLC DTVARADSTS PVVQTAVIAM PLEIDASIDP
      181 LQSHEAVLVS YQGETWIVTT KGRHAIDLTD RALTSSMGIP VTARPTPISE GMFNALPDMG
      241 PWQLPPIPAA GAPNSLGLPD DLVIGSVFQI HTDKGPQYYV VLPDGIAQVN ATTAAALRAT
      301 QAHGLVAPPA MVPSLVVRIA ERVYPSPLPD EPLKIVSRPQ DPALCWSWQR SAGDQSPQST
      361 VLSGRHLPIS PSAMNMGIKQ IHGTATVYLD GGKFVALQSP DPRYTESMYY IDPQGVRYGV
      421 PNAETAKSLG LSSPQNAPWE IVRLLVDGPV LSKDAALLEH DTLPADPSPR KVPAGASGAP
//