LOCUS SIU02526.1 418 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 esx-
1 secretion-associated protein espe protein.
ACCESSION LT708304-3940
PROTEIN_ID SIU02526.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="espe"
/locus_tag="BQ2027_MB3894"
/note="Mb3894, -, len: 418 aa. Equivalent to Rv3864, len:
402 aa, from Mycobacterium tuberculosis strain H37Rv,
(96.2% identity in 418 aa overlap). Conserved hypothetical
protein, similar to Q49722|ML0405|B1620_C2_213|MLCL383.01
HYPOTHETICAL 40.8 KDA PROTEIN from Mycobacterium leprae
(394 aa) FASTA scores: opt: 397, E(): 1.2e-12, (31.0%
identity in 410 aa overlap). Also similar to various
proteins from several organisms e.g. Q9VYF9|CG12723
HYPOTHETICAL PROTEIN from Drosophila melanogaster (Fruit
fly) (450 aa), FASTA scores: opt: 291, E(): 2.3e-07,
(34.6% identity in 130 aa overlap); Q98UE3 PROCOLLAGEN
ALPHA1(III) (FRAGMENT) from Xenopus laevis (African clawed
frog) (117 aa) FASTA scores: opt: 257, E(): 3.6e-06,
(41.75% identity in 103 aa overlap); P27393|CA24_ASCSU
COLLAGEN ALPHA 2(IV) CHAIN PRECURSOR from Ascaris suum
(Pig roundworm) (Ascaris lumbricoides) (1763 aa), FASTA
scores: opt: 273, E(): 5.7e-06, (32.1% identity in 240 aa
overlap); etc. Also similar to O06267|Rv3616c|MTCY07H7B.06
(392 aa) FASTA scores: opt: 389, E(): 3e-12, (31.6%
identity in 399 aa overlap).
REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
36 bp insertion leads to a longer product compared to its
homolog in Mycobacterium tuberculosis strain H37Rv (418 aa
versus 402 aa). Protein product from Mb3894 detected using
shotgun mass spectrometry and SWATH mass spectrometry.
Mb3894 found to be expressed during exponential growth in
Sauton's minimal media by RNA-sequencing."
/db_xref="GOA:A0A1R3Y5Q3"
/db_xref="UniProtKB/TrEMBL:A0A1R3Y5Q3"
BEGIN
1 MASGSGLCKT TSNFIWGQLL LLGEGIPDPG DIFNTGSSLF KQISDKMGLA IPGTNWIGQA
61 AEAYLNQNIA QQLRAQVMGD LDKLTGNMIS NQAKYVSDTR DVLRAMKKMI DGVYKVCKGL
121 EKIPLLGHLW SWELAIPMSG IAMAVVGGAL LYLTIMTLMN ATNLRGILGR LIEMLTTLPK
181 FPGLPGLPSL PDIIDGLWPP KLPDIPIPGL PDIPGLPDFK WPPTPGSPLF PDLPSFPGFP
241 GFPSLPGFPG LPGFPEFPAI PGFPALPGLP SIPNLFPGLP GLGDLLPGVG DLGKLPTWTE
301 LAALPDFLGG FAGLPSLGFG NLLSFASLPT VGQVTATMGQ LQQLVAAGGG PSQLASMGSQ
361 QAQLISSQAQ QGGQQHATLV SDKKEDEEGA AAGVAEAERA PIDAGTAASQ RGQEGTVL
//