LOCUS SIU02521.1 1527 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable ferredoxin-dependent glutamate synthase [nadph] (large subunit) gltb (l-glutamate synthase) (l-glutamate synthetase) (nadh-glutamate synthase) (glutamate synthase (nadh))( nadph-gogat) protein. ACCESSION LT708304-3935 PROTEIN_ID SIU02521.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="gltB" /locus_tag="BQ2027_MB3889C" /note="Mb3889c, gltB, len: 1527 aa. Equivalent to Rv3859c, len: 1527 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 1527 aa overlap). Probable gltB, ferredoxin-dependent glutamate synthase large subunit (EC 1.4.1.13), equivalent to Q9CDD5|GLTB|ML0061 PUTATIVE FERREDOXIN-DEPENDENT GLUTAMATE SYNTHASE from Mycobacterium leprae (1527 aa), FASTA scores: opt: 9277, E(): 0, (90.25% identity in 1527 aa overlap). Also highly similar to many e.g. Q9S2Y9|SC3A3.04c from Streptomyces coelicolor (1514 aa), FASTA scores: opt: 5939, E(): 0, (64.3% identity in 1544 aa overlap); Q9Z465|GLTB from Corynebacterium glutamicum (Brevibacterium flavum) (1510 aa), FASTA scores: opt: 5790, E(): 0, (63.25% identity in 1534 aa overlap); P39812|GLTB_BACSU|GLTA from Bacillus subtilis (1520 aa), FASTA scores: opt: 3445, E(): 2.8e-196, (52.25% identity in 1531 aa overlap); etc. SIMILAR TO OTHER GLUTAMATE SYNTHASES. Protein product from Mb3889c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3889c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y5J1" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="UniProtKB/TrEMBL:A0A1R3Y5J1" BEGIN 1 MTPKRVGLYN PAFEHDSCGV AMVVDMHGRR SRDIVDKAIT ALLNLEHRGA QGAEPRSGDG 61 AGILIQVPDE FLREAVDFEL PAPGSYATGI AFLPQSSKDA AAACAAVQKI AEAEGLQVLG 121 WRSVPTDDSS LGALSRDAMP TFRQVFLAGA SGMALERRCY VVRKRAEHEL GTKGPGQDGP 181 GRETVYFPSL SGQTLVYKGM LTTPQLKAFY LDLQDERLTS ALGIVHSRFS TNTFPSWPLA 241 HPFRRIAHNG EINTVTGNEN WMRAREALIK TDIFGSAADV EKLFPICTPG ASDTARFDEV 301 LELLHLGGRS LAHAVLMMIP EAWERHESMD PARRAFYQYH ASLMEPWDGP ASMTFTDGTV 361 VGAVLDRNGL RPSRIWVTDD GLVVMASEAG VLDLHPSTVV RRMRLQPGRM FLVDTAQGRI 421 VSDEEIKADL AAEHPYQEWL DNGLVPLDEL PEGKDVRMPH HRIVMRQLAF GYTYEELNLL 481 VAPMARLGAE PIGSMGTDTP VAVLSQRPRM LYDYFHQLFA QVTNPPLDAI REEVVTSLQG 541 TTGGERDLLN PDENSCHQIV LPQPILRNHE LAKLVSLDPN DKVNGRPHGL RSKVIRCLYR 601 VSEGGAGLAA ALEEVRGAAA AAIADGARII ILSDRESDEE MAPIPSLLAV AGVHHHLVRE 661 RTRTQVGLVV ESGDAREVHH MAALVGFGAA AINPYLVFES IEDMLDRGVI EGIDRTAALN 721 NYIKAAGKGV LKVMSKMGIS TLASYTGAQL FQAVGISEQV LDEYFTGLTC PTGGITLDDI 781 AADVAARHRL AYLDRPDERA HRELEVGGEY QWRREGEYHL FNPETVFKLQ HSTRTGQYKI 841 FKEYTRLVDD QSERMASLRG LLKFRTGVRP PVPLDEVEPA SEIVKRFSTG AMSYGSISAE 901 AHETLAIAMN RLGARSNCGE GGEDVKRFDR DPNGDWRRSA IKQVASARFG VTSHYLTNCT 961 DLQIKMAQGA KPGEGGQLPG HKVYPWVAEV RHSTPGVGLI SPPPHHDIYS IEDLAQLIHD 1021 LKNANPSARV HVKLVSENGV GTVAAGVSKA HADVVLISGH DGGTGATPLT SMKHAGAPWE 1081 LGLAETQQTL LLNGLRDRIV VQVDGQLKTG RDVMIATLLG AEEFGFATAP LVVAGCIMMR 1141 VCHLDTCPVG VATQNPLLRE RFTGKPEFVE NFFMFIAEEV REYLAQLGFR TVNEAVGQAG 1201 ALDTTLARAH WKAHKLDLAP VLHEPESAFM NQDLYCSSRQ DHGLDKALDQ QLIVMSREAL 1261 DSGKPVRFST TIGNVNRTVG TMLGHELTKA YGGQGLPDGT IDITFDGSAG NSFGAFVPKG 1321 ITLRVYGDAN DYVGKGLSGG RIVVRPSDDA PQDYVAEDNI IGGNVILFGA TSGEVYLRGV 1381 VGERFAVRNS GAHAVVEGVG DHGCEYMTGG RVVILGRTGR NFAAGMSGGV AYVYDPDGEL 1441 PANLNSEMVE LETLDEDDAD WLHGTIQVHV DATDSAVGQR ILSDWSGQQR HFVKVMPRDY 1501 KRVLQAIALA ERDGVDVDKA IMAAAHG //