LOCUS SIU02518.1 335 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 DNA- dependent DNA polymerase beta chain protein. ACCESSION LT708304-3932 PROTEIN_ID SIU02518.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3886C" /note="Mb3886c, -, len: 335 aa. Equivalent to Rv3856c, len: 335 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 335 aa overlap). Conserved hypothetical protein, highly similar to various proteins from diverse organisms e.g. Q9EWR3|3SCF60.21 CONSERVED HYPOTHETICAL PROTEIN from Streptomyces coelicolor (372 aa) FASTA scores: opt: 1286, E(): 2.4e-73, (64.0% identity in 336 aa overlap); P72464|ORF1 from Streptomyces lividans (343 aa), FASTA scores: opt: 1275, E(): 1.1e-72, (60.1% identity in 336 aa overlap); Q9K899|BH3107 DNA-DEPENDENT DNA POLYMERASE BETA CHAIN from Bacillus halodurans (571 aa), FASTA scores: opt: 592, E(): 1.2e-29, (39.15% identity in 240 aa overlap); etc. Protein product from Mb3886c detected using SWATH mass spectrometry. Mb3886c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3Y5G8" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR017078" /db_xref="InterPro:IPR027421" /db_xref="UniProtKB/TrEMBL:A0A1R3Y5G8" BEGIN 1 MDPVTALRQI AYYKDRNRHD PRRVMAYRNA ADIIEGLDDA ARQRHGQANS WQSLAGIGPK 61 TAKVIAQAWS GREPDLLAEL RADAEDLGGG AIRAALRGDL HLHSNWSDGS APIEEMMATA 121 AALGHQYCAL TDHSPRLTIA NGLSPDRLRK QLDVIDELRE KFAPLRILTG IEVDILEDGS 181 LDQEPEMLDR LDIVVASVHS KLSMDSAAMT RRMVRAVANG HTDVLGHCTG RLIAGNRGIR 241 PESKFDAEAV FTACREHGTA VEINSRPERR DPPTRLLHLA RDIGCVFSID TDAHAPGQLD 301 FLGYGAQRAL DAEVPADRIV NTWPADTLLA WTGSH //