LOCUS       SIU02518.1               335 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 DNA-
            dependent DNA polymerase beta chain protein.
ACCESSION   LT708304-3932
PROTEIN_ID  SIU02518.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3886C"
                     /note="Mb3886c, -, len: 335 aa. Equivalent to Rv3856c,
                     len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 335 aa overlap). Conserved
                     hypothetical protein, highly similar to various proteins
                     from diverse organisms e.g. Q9EWR3|3SCF60.21 CONSERVED
                     HYPOTHETICAL PROTEIN from Streptomyces coelicolor (372 aa)
                     FASTA scores: opt: 1286, E(): 2.4e-73, (64.0% identity in
                     336 aa overlap); P72464|ORF1 from Streptomyces lividans
                     (343 aa), FASTA scores: opt: 1275, E(): 1.1e-72, (60.1%
                     identity in 336 aa overlap); Q9K899|BH3107 DNA-DEPENDENT
                     DNA POLYMERASE BETA CHAIN from Bacillus halodurans (571
                     aa), FASTA scores: opt: 592, E(): 1.2e-29, (39.15%
                     identity in 240 aa overlap); etc. Protein product from
                     Mb3886c detected using SWATH mass spectrometry. Mb3886c
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y5G8"
                     /db_xref="InterPro:IPR003141"
                     /db_xref="InterPro:IPR004013"
                     /db_xref="InterPro:IPR010996"
                     /db_xref="InterPro:IPR016195"
                     /db_xref="InterPro:IPR017078"
                     /db_xref="InterPro:IPR027421"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y5G8"
BEGIN
        1 MDPVTALRQI AYYKDRNRHD PRRVMAYRNA ADIIEGLDDA ARQRHGQANS WQSLAGIGPK
       61 TAKVIAQAWS GREPDLLAEL RADAEDLGGG AIRAALRGDL HLHSNWSDGS APIEEMMATA
      121 AALGHQYCAL TDHSPRLTIA NGLSPDRLRK QLDVIDELRE KFAPLRILTG IEVDILEDGS
      181 LDQEPEMLDR LDIVVASVHS KLSMDSAAMT RRMVRAVANG HTDVLGHCTG RLIAGNRGIR
      241 PESKFDAEAV FTACREHGTA VEINSRPERR DPPTRLLHLA RDIGCVFSID TDAHAPGQLD
      301 FLGYGAQRAL DAEVPADRIV NTWPADTLLA WTGSH
//