LOCUS SIU02515.1 157 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 regulator of rnase e activity a rraa protein. ACCESSION LT708304-3929 PROTEIN_ID SIU02515.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="rraa" /locus_tag="BQ2027_MB3883" /note="Mb3883, menG, len: 157 aa. Equivalent to Rv3853, len: 157 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 157 aa overlap). Probable menG, S-adenosylmethionine:2-demethylmenaquinone methyltransferase (EC 2.1.-.-), equivalent to Q9CDD2|MENG|ML0066 PUTATIVE S-ADENOSYLMETHIONINE:2-DEMETHYLMENAQUINONE METHYLTRANSFERASE from Mycobacterium leprae (157 aa) FASTA scores: opt: 896, E(): 1.3e-49, (87.1% identity in 155 aa overlap). Also highly similar to others e.g. Q9S4U0|MENG from Pseudomonas fluorescens (163 aa), FASTA scores: opt: 481, E(): 1.7e-23, (47.0% identity in 149 aa overlap); Q9RW10|DR0859 from Deinococcus radiodurans (160 aa) FASTA scores: opt: 456, E(): 6.3e-22, (45.75% identity in 153 aa overlap); P32165|MENG_ECOLI|B3929|Z5476|ECS4856 from Escherichia coli strain K12 (161 aa), FASTA scores: opt: 428, E(): 3.7e-20, (45.65% identity in 149 aa overlap); etc. Protein product from Mb3883 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3883 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:P0A667" /db_xref="InterPro:IPR005493" /db_xref="InterPro:IPR010203" /db_xref="InterPro:IPR036704" /db_xref="UniProtKB/Swiss-Prot:P0A667" BEGIN 1 MAISFRPTAD LVDDIGPDVR SCDLQFRQFG GRSQFAGPIS TVRCFQDNAL LKSVLSQPSA 61 GGVLVIDGAG SLHTALVGDV IAELARSTGW TGLIVHGAVR DAAALRGIDI GIKALGTNPR 121 KSTKTGAGER DVEITLGGVT FVPGDIAYSD DDGIIVV //