LOCUS       SIU02515.1               157 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 regulator
            of rnase e activity a rraa protein.
ACCESSION   LT708304-3929
PROTEIN_ID  SIU02515.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="rraa"
                     /locus_tag="BQ2027_MB3883"
                     /note="Mb3883, menG, len: 157 aa. Equivalent to Rv3853,
                     len: 157 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 157 aa overlap). Probable menG,
                     S-adenosylmethionine:2-demethylmenaquinone
                     methyltransferase (EC 2.1.-.-), equivalent to
                     Q9CDD2|MENG|ML0066 PUTATIVE
                     S-ADENOSYLMETHIONINE:2-DEMETHYLMENAQUINONE
                     METHYLTRANSFERASE from Mycobacterium leprae (157 aa) FASTA
                     scores: opt: 896, E(): 1.3e-49, (87.1% identity in 155 aa
                     overlap). Also highly similar to others e.g. Q9S4U0|MENG
                     from Pseudomonas fluorescens (163 aa), FASTA scores: opt:
                     481, E(): 1.7e-23, (47.0% identity in 149 aa overlap);
                     Q9RW10|DR0859 from Deinococcus radiodurans (160 aa) FASTA
                     scores: opt: 456, E(): 6.3e-22, (45.75% identity in 153 aa
                     overlap); P32165|MENG_ECOLI|B3929|Z5476|ECS4856 from
                     Escherichia coli strain K12 (161 aa), FASTA scores: opt:
                     428, E(): 3.7e-20, (45.65% identity in 149 aa overlap);
                     etc. Protein product from Mb3883 detected using shotgun
                     mass spectrometry and SWATH mass spectrometry. Mb3883
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P0A667"
                     /db_xref="InterPro:IPR005493"
                     /db_xref="InterPro:IPR010203"
                     /db_xref="InterPro:IPR036704"
                     /db_xref="UniProtKB/Swiss-Prot:P0A667"
BEGIN
        1 MAISFRPTAD LVDDIGPDVR SCDLQFRQFG GRSQFAGPIS TVRCFQDNAL LKSVLSQPSA
       61 GGVLVIDGAG SLHTALVGDV IAELARSTGW TGLIVHGAVR DAAALRGIDI GIKALGTNPR
      121 KSTKTGAGER DVEITLGGVT FVPGDIAYSD DDGIIVV
//