LOCUS SIU02510.1 302 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN protein. ACCESSION LT708304-3924 PROTEIN_ID SIU02510.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3878" /note="Mb3878, -, len: 302 aa. Equivalent to Rv3848, len: 302 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 302 aa overlap). Probable conserved transmembrane protein, similar to hypothetical (transmembrane) proteins e.g. Q9HVG2|PA4629 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (192 aa), FASTA scores: opt: 304, E(): 5.3e-11, (35.05% identity in 174 aa overlap); Q9A5S7|CC2370 HYPOTHETICAL PROTEIN from Caulobacter crescentus (207 aa), FASTA scores: opt: 285, E(): 7.4e-10, (29.9% identity in 184 aa overlap); Q9KY43|SCC8A.05c PUTATIVE INTEGRAL MEMBRANE PROTEIN from Streptomyces coelicolor (193 aa), FASTA scores: opt: 245, E(): 1.6e-07, (32.8% identity in 195 aa overlap); etc. Protein product from Mb3878 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3878 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3Y5F1" /db_xref="InterPro:IPR001727" /db_xref="UniProtKB/TrEMBL:A0A1R3Y5F1" BEGIN 1 MLAATLLSLG AVFLAELGDR SQLITMTYTL RYRWWVVLTG VAIAAFTVHG VAVAIGHFLG 61 STVPARPAAC VSAIAFLIFA VWVWREDTAS DSETSPTAAE PRLALFTVVS SFALAELGDK 121 TTLATVTLAS DHHWAGVWIG TTLGMILADG LAIGAGLLLH RRLPERLLQV LTGLLFLLFG 181 LWLLFDDALG FRSIAIAVTA AVVLAAATTA VSVRVAQTRR RRPTAAATPE DDSTRPERSS 241 VAPGHPGSIL LPLPEVSLRG RRPPSGSPDE RCADPGSKGG SRRISVGCWL PGVGRIRPTR 301 SS //