LOCUS SIU02495.1 116 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 CONSERVED HYPOTHETICAL PROTEIN protein. ACCESSION LT708304-3909 PROTEIN_ID SIU02495.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3866" /note="Mb3866, -, len: 116 aa. Similar to Rv3836, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 115 aa overlap). Conserved hypothetical protein, highly similar to Q9RKJ2|SCD25.30 HYPOTHETICAL 13.1 KDA PROTEIN from Streptomyces coelicolor (116 aa), FASTA scores: opt: 395, E(): 3.3e-19, (54.4% identity in 114 aa overlap); and similar to CAC47753|SMC0379 CONSERVED HYPOTHETICAL PROTEIN from Rhizobium meliloti (Sinorhizobium meliloti) (144 aa) FASTA scores: opt: 194, E(): 6e-06, (33.05% identity in 109 aa overlap); and Q98E37|MLL4425 HYPOTHETICAL PROTEIN from Rhizobium loti (Mesorhizobium loti) (201 aa), FASTA scores: opt: 184, E(): 3.7e-05, (29.75% identity in 121 aa overlap). Contains PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-g) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (116 aa versus 137 aa). Protein product from Mb3866 detected using SWATH mass spectrometry. Mb3866 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="InterPro:IPR010428" /db_xref="InterPro:IPR038555" /db_xref="UniProtKB/TrEMBL:A0A1R3Y6V4" BEGIN 1 MTVRMDPQRF DELVSDALDL IPPELADAMD NVVVLVANRH PQHENLLGQY EGVALTERGS 61 DYAGSLPDAI TIYREALLDA CDSEDEVVDQ VAITVIHEVA HHFGIDDERL DQLGWA //