LOCUS       SIU02495.1               116 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 CONSERVED
            HYPOTHETICAL PROTEIN protein.
ACCESSION   LT708304-3909
PROTEIN_ID  SIU02495.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3866"
                     /note="Mb3866, -, len: 116 aa. Similar to Rv3836, len: 137
                     aa, from Mycobacterium tuberculosis strain H37Rv, (100.0%
                     identity in 115 aa overlap). Conserved hypothetical
                     protein, highly similar to Q9RKJ2|SCD25.30 HYPOTHETICAL
                     13.1 KDA PROTEIN from Streptomyces coelicolor (116 aa),
                     FASTA scores: opt: 395, E(): 3.3e-19, (54.4% identity in
                     114 aa overlap); and similar to CAC47753|SMC0379 CONSERVED
                     HYPOTHETICAL PROTEIN from Rhizobium meliloti
                     (Sinorhizobium meliloti) (144 aa) FASTA scores: opt: 194,
                     E(): 6e-06, (33.05% identity in 109 aa overlap); and
                     Q98E37|MLL4425 HYPOTHETICAL PROTEIN from Rhizobium loti
                     (Mesorhizobium loti) (201 aa), FASTA scores: opt: 184,
                     E(): 3.7e-05, (29.75% identity in 121 aa overlap).
                     Contains PS00142 Neutral zinc metallopeptidases,
                     zinc-binding region signature.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     single base insertion (*-g) introducing a premature stop
                     codon, leads to a shorter product compared to its homolog
                     in Mycobacterium tuberculosis strain H37Rv (116 aa versus
                     137 aa). Protein product from Mb3866 detected using SWATH
                     mass spectrometry. Mb3866 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR010428"
                     /db_xref="InterPro:IPR038555"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y6V4"
BEGIN
        1 MTVRMDPQRF DELVSDALDL IPPELADAMD NVVVLVANRH PQHENLLGQY EGVALTERGS
       61 DYAGSLPDAI TIYREALLDA CDSEDEVVDQ VAITVIHEVA HHFGIDDERL DQLGWA
//