LOCUS       SIU02492.1               263 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 TRANSCRIPTIONAL
            REGULATORY PROTEIN (PROBABLY ARAC-FAMILY) protein.
ACCESSION   LT708304-3906
PROTEIN_ID  SIU02492.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3863"
                     /note="Mb3863, -, len: 263 aa. Equivalent to Rv3833, len:
                     263 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 263 aa overlap). Probable
                     transcriptional regulator belonging to araC family,
                     similar to others e.g. Q9KYN4|SC9H11.05 PUTATIVE
                     ARAC-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces
                     coelicolor (289 aa), FASTA scores: opt: 754, E(): 1.2e-42,
                     (50.45% identity in 232 aa overlap); Q9HXH2|PA3830
                     PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas
                     aeruginosa (270 aa), FASTA scores: opt: 501, E(): 6.2e-26,
                     (34.85% identity in 238 aa overlap); Q9HX87|PA3927
                     PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas
                     aeruginosa (262 aa), FASTA scores: opt: 496, E(): 1.3e-25,
                     (36.45% identity in 266 aa overlap);
                     P76241|YEAM_ECOLI|B1790 HYPOTHETICAL TRANSCRIPTIONAL
                     REGULATOR from Escherichia coli strain K12 (273 aa) FASTA
                     scores: opt: 388, E(): 1.9e-18, (30.5% identity in 223 aa
                     overlap); etc. Contains probable helix-turn-helix motif
                     from aa 164-185, Score 2014 (+6.05 SD). SEEMS TO BELONG TO
                     THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS. Mb3863
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y5E1"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR013096"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="InterPro:IPR018060"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y5E1"
BEGIN
        1 MSENSHHRLA TTSLTLPPGA RIERHRHPSH QIVYPSAGAV SVTTHAGTWI TPVNRAIWIP
       61 AGCWHQHKFH GHTQFHGVAL DPQRYRGGPA TPTVLAVNPL MRELIIACSQ ADRTDTDEHH
      121 RMLAVLQDQL PTTSIREPLW VPSPTDRRLR HACALIADNL TQPLTLQQIG GRIGVSQRTL
      181 SRLFSDELGM TFPQWRTQLR LQHALVLLAE RHDVTSVASE CGWATPSAFI DTYRQAFGHT
      241 PGQAAKPMAA TRLTRLRRAR DRR
//