LOCUS SIU02492.1 263 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ARAC-FAMILY) protein. ACCESSION LT708304-3906 PROTEIN_ID SIU02492.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3863" /note="Mb3863, -, len: 263 aa. Equivalent to Rv3833, len: 263 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 263 aa overlap). Probable transcriptional regulator belonging to araC family, similar to others e.g. Q9KYN4|SC9H11.05 PUTATIVE ARAC-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (289 aa), FASTA scores: opt: 754, E(): 1.2e-42, (50.45% identity in 232 aa overlap); Q9HXH2|PA3830 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (270 aa), FASTA scores: opt: 501, E(): 6.2e-26, (34.85% identity in 238 aa overlap); Q9HX87|PA3927 PROBABLE TRANSCRIPTIONAL REGULATOR from Pseudomonas aeruginosa (262 aa), FASTA scores: opt: 496, E(): 1.3e-25, (36.45% identity in 266 aa overlap); P76241|YEAM_ECOLI|B1790 HYPOTHETICAL TRANSCRIPTIONAL REGULATOR from Escherichia coli strain K12 (273 aa) FASTA scores: opt: 388, E(): 1.9e-18, (30.5% identity in 223 aa overlap); etc. Contains probable helix-turn-helix motif from aa 164-185, Score 2014 (+6.05 SD). SEEMS TO BELONG TO THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS. Mb3863 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y5E1" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="UniProtKB/TrEMBL:A0A1R3Y5E1" BEGIN 1 MSENSHHRLA TTSLTLPPGA RIERHRHPSH QIVYPSAGAV SVTTHAGTWI TPVNRAIWIP 61 AGCWHQHKFH GHTQFHGVAL DPQRYRGGPA TPTVLAVNPL MRELIIACSQ ADRTDTDEHH 121 RMLAVLQDQL PTTSIREPLW VPSPTDRRLR HACALIADNL TQPLTLQQIG GRIGVSQRTL 181 SRLFSDELGM TFPQWRTQLR LQHALVLLAE RHDVTSVASE CGWATPSAFI DTYRQAFGHT 241 PGQAAKPMAA TRLTRLRRAR DRR //