LOCUS SIU02487.1 203 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE RESOLVASE protein. ACCESSION LT708304-3901 PROTEIN_ID SIU02487.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3858C" /note="Mb3858c, -, len: 203 aa. Equivalent to Rv3828c, len 203 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 203 aa overlap). Possible resolvase within IS1537 element, similar to others e.g. Q97X40|SSO1915 FIRST ORF IN TRANSPOSON ISC1913 from Sulfolobus solfataricus (213 aa), FASTA scores: opt: 275, E(): 1.6e-11, (30.6% identity in 196 aa overlap); Q9V1M0|PAB2076 RESOLVASE RELATED PROTEIN from Pyrococcus abyssi (212 aa), FASTA scores: opt: 254, E(): 4.2e-10, (29.95% identity in 197 aa overlap); Q9RMU7|ORFA PUTATIVE TRANSPOSASE (BELONGS TO THE MERR FAMILY OF TRANSCRIPTIONAL REGULATORS) from elicobacter pylori (Campylobacter pylori) (217 aa), FASTA scores: opt: 243, E(): 2.3e-09, (31.8% identity in 154 aa overlap); etc. Also highly similar to proteins from Mycobacterium tuberculosis e.g. O33334|Rv2792c|MTV002.57c RESOLVASE (193 aa), FASTA scores: opt: 970, E(): 1.5e-58, (79.25% identity in 193 aa overlap); O07773|Rv0605|MTCY19H5.17c PUTATIVE RESOLVASE (202 aa), FASTA scores: opt: 964, E(): 4e-58, (76.25% identity in 202 aa overlap); P95116|Rv2979c|MTCY349.08 HYPOTHETICAL 21.4 KDA PROTEIN (194 aa), FASTA scores: opt: 895, E(): 1.8e-53, (74.75% identity in 194 aa overlap); Q10831|YS86_MYCTU|Rv2886c|MT2954|MTCY274.17c HYPOTHETICAL 31.9 KDA PROTEIN (295 aa), FASTA scores: opt: 826, E(): 1.1e-48, (66.2% identity in 204 aa overlap) (similarity only at C-terminus); etc. Contains PS00397 Site-specific recombinases active site. Possible helix-turn-helix motif from aa 11-32, Score 1305 (+3.63 SD)." /db_xref="GOA:A0A1R3Y5C9" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="UniProtKB/TrEMBL:A0A1R3Y5C9" BEGIN 1 MSVVCCRNRW MNLAVWAERN GVAWVIAYRW FRAGLLPVPA QRVGRLILVN DPAVEESGRG 61 RTLVYARVSS ADQRSDLDRR VARVTAWATS QHLSVDKVVA EGGWALNGHR RKFFALLGDP 121 VVTRIVVEHR DRFCWFGSEY VEAALVAQGR ELVVVDLAEV DDDLVGDMTE ILTSMCARLY 181 GERAAQNGAK RALAAAVGDA EAA //