LOCUS       SIU02482.1              1089 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 conserved
            integral membrane transport protein mmpl8 protein.
ACCESSION   LT708304-3896
PROTEIN_ID  SIU02482.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mmpL8"
                     /locus_tag="BQ2027_MB3853C"
                     /note="Mb3853c, mmpL8, len: 1089 aa. Equivalent to
                     Rv3823c, len: 1089 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (99.8% identity in 1089 aa overlap).
                     Probable mmpL8, conserved integral membrane transport
                     protein (see citation below), member of RND superfamily,
                     equivalent to Q49619|MMLA_MYCLE|MMPL10|TP1|ML1231|B1170_C1
                     _181 PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae
                     (1008 aa), FASTA scores: opt: 2718, E(): 7.3e-149, (56.25%
                     identity in 1028 aa overlap). Also similar to others e.g.
                     Q9XCF6|TMTPC from Mycobacterium avium (974 aa), FASTA
                     scores: opt: 660, E(): 2.7e-30, (28.2% identity in 1050 aa
                     overlap); Q9XCF5|TMTPB from Mycobacterium avium (963 aa),
                     FASTA scores: opt: 653, E(): 6.7e-30, (27.0% identity in
                     1014 aa overlap); Q9KH53|TMTPC from Mycobacterium
                     smegmatis (994 aa), FASTA scores: opt: 648, E(): 1.3e-29,
                     (28.45% identity in 1013 aa overlap); etc. Also highly
                     similar to other mmpL proteins from Mycobacterium
                     tuberculosis; O50439|MMLA_MYCTU|MMPL10|RV1183|MT1220|MTV00
                     5.19 (1002 aa), FASTA scores: opt: 2777, E(): 2.9e-152,
                     (58.25% identity in 996 aa overlap);
                     Q50585|MMLC_MYCTU|MMPL12|Rv1522c|MT1573|MTCY19G5.06 (1146
                     aa), FASTA scores: opt: 2433, E(): 2.1e-132, (49.9%
                     identity in 1050 aa overlap); and similar to others e.g.
                     P95235|MML9_MYCTU|MMPL9|Rv2339|MT2402|MTCY98.08 (962 aa),
                     FASTA scores: opt: 651, E(): 8.8e-30, (28.6% identity in
                     1038 aa overlap); etc. BELONGS TO THE MMPL FAMILY. Mb3853c
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:Q7TVL0"
                     /db_xref="InterPro:IPR000731"
                     /db_xref="InterPro:IPR004707"
                     /db_xref="InterPro:IPR004869"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TVL0"
BEGIN
        1 MCDVLMQPVR TPRPSTNLRS KPLRPTGDGG VFPRLGRLIV RRPWVVIAFW VALAGLLAPT
       61 VPSLDAISQR HPVAILPSDA PVLVSTRQMT AAFREAGLQS VAVVVLSDAK GLGAADERSY
      121 KELVDALRRD TRDVVMLQDF VTTPPLRELM TSKDNQAWIL PVGLPGDLGS TQSKQAYARV
      181 ADIVEHQVAG STLTANLTGP AATVADLNLT GQRDRSRIEF AITILLLVIL LIIYRNPITM
      241 VLPLITIGMS VVVAQRLVAI AGLAGLGIAN QSIIFMSGMM VGAGTDYAVF LISRYHDYLR
      301 QGADSDQAVK KALTSIGKVI AASAATVAIT FLGMVFTQLG ILKTVGPMLG ISVAVVFFAA
      361 VTLLPALMVL TGRRGWIAPR RDLTRRFWRS SGVHIVRRPK THLLASALVL VILAGCAGLA
      421 RYNYDDRKTL PASVESSIGY AALDKHFPSN LIIPEYLFIQ SSTDLRTPKA LADLEQMVQR
      481 VSQVPGVAMV RGITRPAGRS LEQARTSWQA GEVGSKLDEG SKQIAAHTGD IDKLAGGANL
      541 MASKLGDVRA QVNRAISTVG GLIDALAYLQ DLLGGNRVLG ELEGAEKLIG SMRALGDTID
      601 ADASFVANNT EWASPVLGAL DSSPMCTADP ACASARTELQ RLVTARDDGT LAKISELARQ
      661 LQATRAVQTL AATVSGLRGA LATVIRAMGS LGMSSPGGVR SKINLVNKGV NDLADGSRQL
      721 AEGVQLLVDQ VKKMGFGLGE ASAFLLAMKD TATTPAMAGF YIPPELLSYA TGESVKAETM
      781 PSEYRDLLGG LNVDQLKKVA AAFISPDGHS IRYLIQTDLN PFSTAAMDQI DAITAAARGA
      841 QPNTALADAK VSVVGLPVVL KDTRDYSDHD LRLIIAMTVC IVLLILIVLL RAIVAPLYLI
      901 GSVIVSYLAA LGIGVIVFQF LLGQEMHWSI PGLTFVILVA VGADYNMLLI SRLREEAVLG
      961 VRSGVIRTVA STGGVITAAG LIMAASMYGL VFASLGSVVQ GAFVLGTGLL LDTFLVRTVT
     1021 VPAIAVLVGQ ANWWLPSSWR PATWWPLGRR RGRAQRTKRK PLLPKEEEEQ SPPDDDDLIG
     1081 LWLHDGLRL
//