LOCUS SIU02472.1 273 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Cof family hydrolase protein. ACCESSION LT708304-3886 PROTEIN_ID SIU02472.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3843C" /note="Mb3843c, -, len: 273 aa. Equivalent to Rv3813c, len: 273 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 273 aa overlap). Conserved hypothetical protein, equivalent to Q9CDB9|ML0089 HYPOTHETICAL PROTEIN from Mycobacterium leprae (281 aa) FASTA scores: opt: 1479, E(): 9.6e-81, (80.45% identity in 271 aa overlap); and similar to Q98LI0|MLL1014 from (280 aa) . Also similar to many hypothetical proteins from several organisms e.g. Q9ZBX2|SCD78.27c from Streptomyces coelicolor (280 aa), FASTA scores: opt: 597, E(): 2.2e-28, (43.25% identity in 266 aa overlap); Q9RXR7|DR0240 from Deinococcus radiodurans (284 aa), FASTA scores: opt: 543, E(): 3.5e-25, (38.65% identity in 264 aa overlap); Q99YH5|SPY1700 from Streptococcus pyogenes (274 aa) FASTA scores: opt: 373, E(): 4.3e-15, (30.75% identity in 270 aa overlap); P70947|YITU from Bacillus subtilis (270 aa) FASTA scores: opt: 353, E(): 6.5e-14, (30.0% identity in 280 aa overlap); etc. Protein product from Mb3843c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3843c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y5B8" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="UniProtKB/TrEMBL:A0A1R3Y5B8" BEGIN 1 MKPTVPALVA CDVDGTLLDD GETVTKRTRD AVHAAVDAGT HFILATGRPP RWVRPIVDAL 61 GFAPMAVCAN GAVIYDPGTD RVTSVRTLPV DALATLAEVA TRVIPGAGLA VERIGERAHD 121 TATPQFVSSP GYEHAWLNPD NTEVSIDHLL SAPAIKLLIR KAGAASADMA AELAKHVGFE 181 GDITYSTNNG LVEIVPLGIS KATGVDEIAR PLGISDAEVV AFGDMPNDVP MLLRAGLGVA 241 MGNAHPDALA VADEVTAPNS EDGVARVLER WWS //