LOCUS       SIU02468.1               399 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 UDP-
            GALACTOPYRANOSE MUTASE GLF (UDP-GALP MUTASE) (NAD+-FLAVIN
            ADENINE DINUCLEOTIDE-REQUIRING ENZYME) protein.
ACCESSION   LT708304-3882
PROTEIN_ID  SIU02468.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="glf"
                     /locus_tag="BQ2027_MB3839C"
                     /standard_name="ceoA"
                     /note="Mb3839c, glf, len: 399 aa. Equivalent to Rv3809c,
                     len: 399 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 399 aa overlap). glf (alternate gene
                     name: ceoA), UDP-galactopyranose mutase (EC 5.4.99.9) (see
                     citations below), identical to previously sequenced gene,
                     and equivalent to Q9CDB8|GLF|ML0092 PUTATIVE
                     UDP-GALACTOPYRANOSE MUTASE from Mycobacterium leprae (413
                     aa), FASTA scores: opt: 2347, E(): 1.3e-140, (86.6%
                     identity in 396 aa overlap). Also highly similar to others
                     e.g. AAK61905|EPSJ UDP-GALACTOPYRANOSE MUTASE (PROTEIN
                     INVOLVED IN EXOPOLYSACCHARIDES BIOSYNTHESIS) from
                     Streptococcus thermophilus (365 aa), FASTA scores: opt:
                     972, E(): 5.9e-54, (45.85% identity in 375 aa overlap);
                     P37747|GLF_ECOLI|B2036 UDP-GALACTOPYRANOSE MUTASE from
                     Escherichia coli strain K12 (367 aa), FASTA scores: opt:
                     958, E(): 4.5e-53, (43.55% identity in 379 aa overlap);
                     O86897|CAP33FN from Streptococcus pneumoniae (369 aa)
                     FASTA scores: opt: 954, E(): 8.1e-53, (44.8% identity in
                     375 aa overlap); etc. COFACTOR: FAD (BY SIMILARITY).
                     N-TERMINAL SHOWS SIMILARITY TO FAD OR NAD CONTAINING
                     PROTEINS. Protein product from Mb3839c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb3839c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y5B9"
                     /db_xref="InterPro:IPR004379"
                     /db_xref="InterPro:IPR015899"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y5B9"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MQPMTARFDL FVVGSGFFGL TIAERVATQL DKRVLVLERR PHIGGNAYSE AEPQTGIEVH
       61 KYGAHLFHTS NKRVWDYVRQ FTDFTDYRHR VFAMHNGQAY QFPMGLGLVS QFFGKYFTPE
      121 QARQLIAEQA AEIDTADAQN LEEKAISLIG RPLYEAFVKG YTAKQWQTDP KELPAANITR
      181 LPVRYTFDNR YFSDTYEGLP TDGYTAWLQN MAADHRIEVR LNTDWFDVRG QLRPGSPAAP
      241 VVYTGPLDRY FDYAEGRLGW RTLDFEVEVL PIGDFQGTAV MNYNDLDVPY TRIHEFRHFH
      301 PERDYPTDKT VIMREYSRFA EDDDEPYYPI NTEADRALLA TYRARAKSET ASSKVLFGGR
      361 LGTYQYLDMH MAIASALNMY DNVLAPHLRD GVPLLQDGA
//