LOCUS SIU02462.1 299 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 SECRETED
MPT51/MPB51 ANTIGEN PROTEIN FBPD (MPT51/MPB51 ANTIGEN
85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-
BINDING PROTEIN C) (85C) protein.
ACCESSION LT708304-3876
PROTEIN_ID SIU02462.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="fbpD"
/locus_tag="BQ2027_MB3833C"
/standard_name="mpt51; mpb51; fbpC1"
/note="Mb3833c, fbpD, len: 299 aa. Equivalent to Rv3803c,
len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,
(100.0% identity in 299 aa overlap). fbpD (alternate gene
names: mpt51, mpb51, fbpC1), secreted MPB51/MPT51 antigen
protein (fibronectin-binding protein C) (mycolyl
transferase 85C) (EC 2.3.1.-) (see citations below),
identical to Q48923|MPT51|MPB51 ANTIGEN PRECURSOR from
Mycobacterium bovis (299 aa), FASTA scores: opt: 2093,
E(): 1.5e-112, (100.0% identity in 299 aa overlap) (see
second citation below); and highly similar to other
Mycobacterial antigen precursors e.g.
Q05868|MPT5_MYCLE|MPT51|ML0098 MPT51 ANTIGEN PRECURSOR
from Mycobacterium leprae (301 aa), FASTA scores: opt:
1624, E(): 9.8e-86, (77.8% identity in 302 aa overlap);
O52972|A85C_MYCAV|FBPC ANTIGEN 85-C PRECURSOR
(FIBRONECTIN-BINDING PROTEIN C) from Mycobacterium avium
(352 aa), FASTA scores: opt: 753, E(): 6.6e-36, (41.5%
identity in 315 aa overlap); P21160|A85B_MYCKA ANTIGEN
85-B PRECURSOR (FIBRONECTIN-BINDING PROTEIN B) from
Mycobacterium kansasii (325 aa), FASTA scores: opt: 574,
E(): 1.1e-25, (37.55% identity in 309 aa overlap);
P12942|A85B_MYCBO ANTIGEN 85-B PRECURSOR from
Mycobacterium bovis (323 aa), FASTA scores: opt: 572, E():
1.4e-25, (39.85% identity in 291 aa overlap); etc. Also
similar to P31953|A85C_MYCTU|FBPC|MPT45|Rv0129c|MTCI5.03c|
FBPC2 SECRETED ANTIGEN 85-C (MYCOLYL TRANSFERASE 85C)
(FIBRONECTIN-BINDING PROTEIN C) from Mycobacterium
tuberculosis (340 aa), FASTA scores: opt: 751, E():
8.4e-36, (40.65% identity in 310 aa overlap);
P17944|A85A_MYCTU|FBPA|MPT44|Rv3804c|MT3911|MTV026.09c
SECRETED ANTIGEN 85-A (MYCOLYL TRANSFERASE 85A)
(FIBRONECTIN-BINDING PROTEIN A) from Mycobacterium
tuberculosis (338 aa), FASTA scores: opt: 592, E(): 1e-26,
(39.05% identity in 302 aa overlap); etc. Contains PS00178
Aminoacyl-transfer RNA synthetases class-I signature. Note
that the secreted protein MPB51 is one of the major
proteins in the culture filtrate of Mycobacterium bovis
BCG. Protein product from Mb3833c detected using shotgun
mass spectrometry and SWATH mass spectrometry. Mb3833c
found to be expressed during exponential growth in
Sauton's minimal media by RNA-sequencing (TPM > 20)."
/db_xref="GOA:P0A4V7"
/db_xref="InterPro:IPR000801"
/db_xref="InterPro:IPR029058"
/db_xref="UniProtKB/Swiss-Prot:P0A4V7"
/experiment="experimental evidence, no additional details
recorded"
BEGIN
1 MKGRSALLRA LWIAALSFGL GGVAVAAEPT AKAAPYENLM VPSPSMGRDI PVAFLAGGPH
61 AVYLLDAFNA GPDVSNWVTA GNAMNTLAGK GISVVAPAGG AYSMYTNWEQ DGSKQWDTFL
121 SAELPDWLAA NRGLAPGGHA AVGAAQGGYG AMALAAFHPD RFGFAGSMSG FLYPSNTTTN
181 GAIAAGMQQF GGVDTNGMWG APQLGRWKWH DPWVHASLLA QNNTRVWVWS PTNPGASDPA
241 AMIGQAAEAM GNSRMFYNQY RSVGGHNGHF DFPASGDNGW GSWAPQLGAM SGDIVGAIR
//