LOCUS SIU02453.1 1098 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 INTEGRAL
MEMBRANE INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE EMBB
(ARABINOSYLINDOLYLACETYLINOSITOL SYNTHASE) protein.
ACCESSION LT708304-3867
PROTEIN_ID SIU02453.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="embB"
/locus_tag="BQ2027_MB3824"
/note="Mb3824, embB, len: 1098 aa. Equivalent to Rv3795,
len: 1098 aa, from Mycobacterium tuberculosis strain
H37Rv, (99.8% identity in 1098 aa overlap). embB, integral
membrane protein, indolylacetylinositol
arabinosyltransferase (EC 2.4.2.34) (see citations below),
equivalent to P71486|EMBB ARABINOSYL TRANSFERASE from
Mycobacterium avium (1065 aa), FASTA scores: opt: 4998,
E(): 0, (83.25% identity in 1076 aa overlap);
Q9CDA9|EMBB|ML0104 PUTATIVE ARABINOSYL TRANSFERASE from
Mycobacterium leprae (1083 aa), FASTA scores: opt: 4706,
E(): 0, (78.0% identity in 1101 aa overlap); O30406|EMBB
(alias Q50395) PUTATIVE ARABINOSYL TRANSFERASE from
Mycobacterium smegmatis (1082 aa), FASTA scores: opt:
4163, E(): 0, (68.4% identity in 1091 aa overlap); etc.
Also similar to Q50393|EMBC PUTATIVE ARABINOSYL
TRANSFERASE from Mycobacterium smegmatis (1074 aa), FASTA
scores: opt: 2482, E(): 5e-135, (44.7% identity in 1101 aa
overlap); Q9CDA7|EMBC|ML0106 PUTATIVE ARABINOSYL
TRANSFERASE from Mycobacterium leprae (1070 aa), FASTA
scores: opt: 2259, E(): 3.4e-122, (43.4% identity in 1104
aa overlap); etc. Also similar to
P72059|EMBC|Rv3793|MTCY13D12.27 INDOLYLACETYLINOSITOL
ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis
(1094 aa), FASTA scores: opt: 2276, E(): 3.6e-123, (44.45%
identity in 1118 aa overlap); and
P72060|EMBA|Rv3794|MTCY13D12.28 INDOLYLACETYLINOSITOL
ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis
(1094 aa), FASTA scores: opt: 1288, E(): 2.5e-66, (42.35%
identity in 1114 aa overlap). Supposed regulated by
embR|Rv1267c. Protein product from Mb3824 detected using
shotgun mass spectrometry and SWATH mass spectrometry.
Mb3824 found to be expressed during exponential growth in
Sauton's minimal media by RNA-sequencing."
/db_xref="GOA:Q7TVN3"
/db_xref="InterPro:IPR007680"
/db_xref="InterPro:IPR027451"
/db_xref="InterPro:IPR032731"
/db_xref="InterPro:IPR040920"
/db_xref="InterPro:IPR042486"
/db_xref="UniProtKB/Swiss-Prot:Q7TVN3"
/experiment="experimental evidence, no additional details
recorded"
BEGIN
1 MTQCASRRKS TPSRAILGAF ASARGTRWVA TIAGLIGFVL SVATPLLPVV QTTAMLDWPQ
61 RGQLGSVTAP LISLTPVDFT ATVPCDVVRA MPPAGGVVLG TAPKQGKDAN LQALFVVVSA
121 QRVDVTDRNV VILSVPREQV TSPQCQRIEV TSTHAGTFAN FVGLKDPSGA PLRSGFPDPN
181 LRPQIVGVFT DLTGPAPPGL AVSATIDTRF STRPTTLKLL AIIGAIVATV VALIALWRLD
241 QLDGRGSIAQ LLLRPFRPAS SPGGMRRLIP ASWRTFTLTD AVVIFGFLLW HVIGANSSDD
301 GYILGMARVA DHAGYMSNYF RWFGSPEDPF GWYYNLLALM THVSDASLWM RLPDLAAGLV
361 CWLLLSREVL PRLGPAVAAS KPAYWAAAMV LLTAWMPFNN GLRPEGIIAL GSLVTYVLIE
421 RSMRYSRLTP AALAVVTAAF TLGVQPTGLI AVAALVAGGR PMLRILVRRH RLVGTLPLVS
481 PMLAAGTVIL TVVFADQTLS TVLEATRVRA KIGPSQAWYT ENLRYYYLIL PTVDGSLSRR
541 FGFLITALCL FTAVFIMLRR KRIPSVARGP AWRLMGVIFG TMFFLMFTPT KWVHHFGLFA
601 AVGAAMAALT TVLVSPSVLR WSRNRMAFLA ALFFLLALCW ATTNGWWYVS SYGVPFNSAM
661 PKIDGITVST IFFALFAIAA GYAAWLHFAP RGAGEGRLIR ALTTAPVPIV AGFMAAVFVA
721 SMVAGIVRQY PTYSNGWSNV RAFVGGCGLA DDVLVEPDTN AGFMKPLDGD SGSWGPLGPL
781 GGVNPVGFTP NGVPEHTVAE AIVMKPNQPG TDYDWDAPTK LTSPGINGST VPLPYGLDPA
841 RVPLAGTYTT GAQQQSTLVS AWYLLPKPDD GHPLVVVTAA GKIAGNSVLH GYTPGQTVVL
901 EYAMPGPGAL VPAGRMVPDD LYGEQPKAWR NLRFARAKMP ADAVAVRVVA EDLSLTPEDW
961 IAVTPPRVPD LRSLQEYVGS TQPVLLDWAV GLAFPCQQPM LHANGIAEIP KFRITPDYSA
1021 KKLDTDTWED GTNGGLLGIT DLLLRAHVMA TYLSRDWARD WGSLRKFDTL VDAPPAQLEL
1081 GTATRSGLWS PGKIRIGP
//