LOCUS SIU02451.1 1094 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 INTEGRAL
MEMBRANE INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE EMBC
(ARABINOSYLINDOLYLACETYLINOSITOL SYNTHASE) protein.
ACCESSION LT708304-3865
PROTEIN_ID SIU02451.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="embC"
/locus_tag="BQ2027_MB3822"
/note="Mb3822, embC, len: 1094 aa. Equivalent to Rv3793,
len: 1094 aa, from Mycobacterium tuberculosis strain
H37Rv, (99.9% identity in 1094 aa overlap). embC, integral
membrane protein, indolylacetylinositol
arabinosyltransferase (EC 2.4.2.34) (see citations below),
equivalent to Q9CDA7|EMBC|ML0106 PUTATIVE ARABINOSYL
TRANSFERASE from Mycobacterium leprae (1070 aa) FASTA
scores: opt: 6078,E(): 0, (82.95% identity in 1072 aa
overlap); Q50393|EMBC PUTATIVE ARABINOSYL TRANSFERASE from
Mycobacterium smegmatis (1074 aa), FASTA scores: opt:
5523, E(): 0, (75.35% identity in 1072 aa overlap). Also
similar to Q9CDA9|EMBB| ML0104 PUTATIVE ARABINOSYL
TRANSFERASE from Mycobacterium leprae (1083 aa), FASTA
scores: opt: 2789, E(): 1.9e-156, (44.0% identity in 1095
aa overlap); O30406|EMBB PUTATIVE ARABINOSYL TRANSFERASE
from Mycobacterium smegmatis (1082 aa), FASTA scores: opt:
2746, E(): 6.4e-154, (44.6% identity in 1096 aa overlap);
etc. Also similar to to P72030|EMBB|Rv3795|MTCY13D12.29
INDOLYLACETYLINOSITOL ARABINOSYLTRANSFERASE from
Mycobacterium tuberculosis (1098 aa), FASTA scores: opt:
2276, E(): 3.1e-126, (44.45% identity in 1118 aa overlap);
and P72060|EMBA|Rv3794|MTCY13D12.28 INDOLYLACETYLINOSITOL
ARABINOSYLTRANSFERASE from Mycobacterium tuberculosis
(1094 aa), FASTA scores: opt: 1974, E(): 1.9e-108, (41.0%
identity in 1110 aa overlap). Contains PS00044 Bacterial
regulatory proteins, lysR family signature; and PS00017
ATP/GTP-binding site motif A (P-loop). Protein product
from Mb3822 detected using shotgun mass spectrometry and
SWATH mass spectrometry. Mb3822 found to be expressed
during exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="GOA:Q7TVN4"
/db_xref="InterPro:IPR007680"
/db_xref="InterPro:IPR027451"
/db_xref="InterPro:IPR032731"
/db_xref="InterPro:IPR040920"
/db_xref="InterPro:IPR042486"
/db_xref="UniProtKB/Swiss-Prot:Q7TVN4"
/experiment="experimental evidence, no additional details
recorded"
BEGIN
1 MATEAAPPRI AVRLPSTSVR DAGANYRIAR YVAVVAGLLG AVLAIATPLL PVNQTTAQLN
61 WPQNGTFASV EAPLIGYVAT DLNITVPCQA AAGLAGSQNT GKTVLLSTVP KQAPKAVDRG
121 LLLQRANDDL VLVVRNVPLV TAPLSQVLGP TCQRLTFTAH ADRVAAEFVG LVQGPNAEHP
181 GAPLRGERSG YDFRPQIVGV FTDLAGPAPP GLSFSASVDT RYSSSPTPLK MAAMILGVAL
241 TGAALVALHI LDTADGMRHR RFLPARWWSI GGLDTLVIAV LVWWHFVGAN TSDDGYILTM
301 ARVSEHAGYM ANYYRWFGTP EAPFGWYYDL LALWAHVSTA SIWMRLPTLA MALTCWWVIS
361 REVIPRLGHA VKTSRAAAWT AAGMFLAVWL PLDNGLRPEP IIALGILLTW CSVERAVATS
421 RLLPVAIACI IGALTLFSGP TGIASIGALL VAIGPLRTIL HRRSRRFGVL PLVAPILAAA
481 TVTAIPIFRD QTFAGEIQAN LLKRAVGPSL KWFDEHIRYE RLFMASPDGS IARRFAVLAL
541 VLALAVSVAM SLRKGRIPGT AAGPSRRIIG ITIISFLAMM FTPTKWTHHF GVFAGLAGSL
601 GALAAVAVTG AAMRSRRNRT VFAAVVVFVL ALSFASVNGW WYVSNFGVPW SNSFPKWRWS
661 LTTALLELTV LVLLLAAWFH FVANGDGRRT ARPTRFRARL AGIVQSPLAI ATWLLVLFEV
721 VSLTQAMISQ YPAWSVGRSN LQALAGKTCG LAEDVLVELD PNAGMLAPVT APLADALGAG
781 LSEAFTPNGI PADVTADPVM ERPGDRSFLN DDGLITGSEP GTEGGTTAAP GINGSRARLP
841 YNLDPARTPV LGSWRAGVQV PAMLRSGWYR LPTNEQRDRA PLLVVTAAGR FDSREVRLQW
901 ATDEQAAAGH HGGSMEFADV GAAPAWRNLR APLSAIPSTA TQVRLVADDQ DLAPQHWIAL
961 TPPRIPRVRT LQNVVGAADP VFLDWLVGLA FPCQRPFGHQ YGVDETPKWR ILPDRFGAEA
1021 NSPVMDHNGG GPLGITELLM RATTVASYLK DDWFRDWGAL QRLTPYYPDA QPADLNLGTV
1081 TRSGLWSPAP LRRG
//