LOCUS SIU02441.1 280 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE O-ANTIGEN/LIPOPOLYSACCHARIDE TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER RFBD protein. ACCESSION LT708304-3855 PROTEIN_ID SIU02441.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="rfbD" /locus_tag="BQ2027_MB3812" /note="Mb3812, rfbD, len: 280 aa. Equivalent to Rv3783, len: 280 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 280 aa overlap). Possible rfbD, polysaccharide-transport integral membrane protein ABC transporter (see citation below), involved in O-antigen/lipopolysaccharides (LPS) transport, equivalent to Q9CDA2|ML0112 PUTATIVE ABC TRANSPORTER COMPONENT from Mycobacterium leprae (276 aa), FASTA scores: opt: 1646, E(): 4e-102, (84.3% identity in 280 aa overlap). Also highly similar to Q9PAF1|XF2567 ABC TRANSPORTER PERMEASE PROTEIN from Xylella fastidiosa (267 aa), FASTA scores: opt: 723, E(): 7.6e-41, (41.3% identity in 259 aa overlap); and similar to others e.g. Q56902|RFBD_YEREN O-ANTIGEN EXPORT SYSTEM PERMEASE PROTEIN from Yersinia enterocolitica (259 aa), FASTA scores: opt: 566, E(): 2e-30, (28.05% identity in 264 aa overlap); Q06955|RFBH RFBH PROTEIN (involved in the export of lipopolysaccharide) (alias Q9KVA3|VC0246) LIPOPOLYSACCHARIDE/O-ANTIGEN TRANSPORT PROTEIN from Vibrio cholerae (257 aa), FASTA scores: opt: 358, E(): 1.3e-16, (24.4% identity in 258 aa overlap); Q9HTB8|WZM|PA5451 MEMBRANE SUBUNIT OF A-BAND LPS EFFLUX TRANSPORTER from Pseudomonas aeruginosa (265 aa), FASTA scores: opt: 263, E(): 2.7e-10, (25.45% identity in 263 aa overlap); etc. BELONGS TO THE ABC-2 SUBFAMILY OF INTEGRAL MEMBRANE PROTEINS. Protein product from Mb3812 detected using shotgun mass spectrometry. Mb3812 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y577" /db_xref="InterPro:IPR013525" /db_xref="UniProtKB/TrEMBL:A0A1R3Y577" BEGIN 1 MTFMDAQASF QTQSRTLARV RGDLVDGFRR HELWLHLGWQ DIKQRYRRSV LGPFWITIAT 61 GTTAVAMGGL YSKLFRLELS EHLPYVTLGL IVWNLINAAI LDGAEVFVAN EGLIKQLPAP 121 LSVHVYRLVW RQMIFFAHNI VIYFVIAIIF PKPWSWADLS FLPALALIFL NCVWVSLCFG 181 ILATRYRDIG PLLFSVVQLL FFMTPIIWND ETLRRQGAGR WSSIVELNPL LHYLDIVRAP 241 LLGAHQELRH WLVVLVLTVV GWMLAAFAMR QYRARVPYWV //