LOCUS       SIU02441.1               280 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            O-ANTIGEN/LIPOPOLYSACCHARIDE TRANSPORT INTEGRAL MEMBRANE
            PROTEIN ABC TRANSPORTER RFBD protein.
ACCESSION   LT708304-3855
PROTEIN_ID  SIU02441.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="rfbD"
                     /locus_tag="BQ2027_MB3812"
                     /note="Mb3812, rfbD, len: 280 aa. Equivalent to Rv3783,
                     len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 280 aa overlap). Possible rfbD,
                     polysaccharide-transport integral membrane protein ABC
                     transporter (see citation below), involved in
                     O-antigen/lipopolysaccharides (LPS) transport, equivalent
                     to Q9CDA2|ML0112 PUTATIVE ABC TRANSPORTER COMPONENT from
                     Mycobacterium leprae (276 aa), FASTA scores: opt: 1646,
                     E(): 4e-102, (84.3% identity in 280 aa overlap). Also
                     highly similar to Q9PAF1|XF2567 ABC TRANSPORTER PERMEASE
                     PROTEIN from Xylella fastidiosa (267 aa), FASTA scores:
                     opt: 723, E(): 7.6e-41, (41.3% identity in 259 aa
                     overlap); and similar to others e.g. Q56902|RFBD_YEREN
                     O-ANTIGEN EXPORT SYSTEM PERMEASE PROTEIN from Yersinia
                     enterocolitica (259 aa), FASTA scores: opt: 566, E():
                     2e-30, (28.05% identity in 264 aa overlap); Q06955|RFBH
                     RFBH PROTEIN (involved in the export of
                     lipopolysaccharide) (alias Q9KVA3|VC0246)
                     LIPOPOLYSACCHARIDE/O-ANTIGEN TRANSPORT PROTEIN from Vibrio
                     cholerae (257 aa), FASTA scores: opt: 358, E(): 1.3e-16,
                     (24.4% identity in 258 aa overlap); Q9HTB8|WZM|PA5451
                     MEMBRANE SUBUNIT OF A-BAND LPS EFFLUX TRANSPORTER from
                     Pseudomonas aeruginosa (265 aa), FASTA scores: opt: 263,
                     E(): 2.7e-10, (25.45% identity in 263 aa overlap); etc.
                     BELONGS TO THE ABC-2 SUBFAMILY OF INTEGRAL MEMBRANE
                     PROTEINS. Protein product from Mb3812 detected using
                     shotgun mass spectrometry. Mb3812 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y577"
                     /db_xref="InterPro:IPR013525"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y577"
BEGIN
        1 MTFMDAQASF QTQSRTLARV RGDLVDGFRR HELWLHLGWQ DIKQRYRRSV LGPFWITIAT
       61 GTTAVAMGGL YSKLFRLELS EHLPYVTLGL IVWNLINAAI LDGAEVFVAN EGLIKQLPAP
      121 LSVHVYRLVW RQMIFFAHNI VIYFVIAIIF PKPWSWADLS FLPALALIFL NCVWVSLCFG
      181 ILATRYRDIG PLLFSVVQLL FFMTPIIWND ETLRRQGAGR WSSIVELNPL LHYLDIVRAP
      241 LLGAHQELRH WLVVLVLTVV GWMLAAFAMR QYRARVPYWV
//