LOCUS       SIU02439.1               273 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            O-ANTIGEN/LIPOPOLYSACCHARIDE TRANSPORT ATP-BINDING PROTEIN
            ABC TRANSPORTER RFBE protein.
ACCESSION   LT708304-3853
PROTEIN_ID  SIU02439.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="rfbE"
                     /locus_tag="BQ2027_MB3810"
                     /note="Mb3810, rbfE, len: 273 aa. Equivalent to Rv3781,
                     len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 273 aa overlap). Probable rfbE,
                     polysaccharide-transport ATP-binding protein ABC
                     transporter (see citation below), involved in
                     O-antigen/lipopolysaccharides (LPS) transport, equivalent
                     to Q9CDA0|ML0114 PUTATIVE ABC TRANSPORTER ATP-BINDING
                     COMPONENT from Mycobacterium leprae (272 aa), FASTA
                     scores: opt: 1581, E(): 3e-83, (91.4% identity in 267 aa
                     overlap). Also highly similar to AAK71283 LPS/O-ANTIGEN
                     EXPORT PERMEASE from Coxiella burnetii (258 aa), FASTA
                     scores: opt: 793, E(): 2.5e-38, (45.45% identity in 253 aa
                     overlap); Q9PAF0|XF2568 ABC TRANSPORTER ATP-BINDING
                     PROTEIN from Xylella fastidiosa (246 aa), FASTA scores:
                     opt: 758, E(): 2.4e-36, (47.75% identity in 243 aa
                     overlap); Q56903|RFBE_YEREN O-ANTIGEN EXPORT SYSTEM
                     ATP-BINDING PROTEIN from Yersinia enterocolitica (239 aa),
                     FASTA scores: opt: 697, E(): 7e-33, (48.65% identity in
                     224 aa overlap); Q50863|RFBB_MYXXA O-ANTIGEN EXPORT SYSTEM
                     ATP-BINDING from Myxococcus xanthus (437 aa), FASTA
                     scores: opt: 605, E(): 2e-27, (42.05% identity in 207 aa
                     overlap); etc. Contains PS00017 ATP/GTP-binding site motif
                     A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN
                     FAMILY (ABC TRANSPORTERS). Protein product from Mb3810
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3810 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y583"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y583"
BEGIN
        1 MSDPHHPHIQ THNAWVEFPI FDAKSRSLKK AVLGKAGGTI GRNNSNVVVI EALRDITMEL
       61 NLGDRVGLVG HNGAGKSTLL RLLSGIYEPT RGWAKVTGRV APVFDLGIGM DPEISGYENI
      121 IIRGLFLGQT RKQMQAKVDE IAEFTELGEY LSMPLRTYST GMRVRLAMGV VTSIDPEILL
      181 LDEGIGAVDA DFLRKAQSRL QNLVERSGIL VFASHSNEFL ARLCKTAIWI DHGVIRLAGG
      241 IEEVVRAYEG EDAARHVREV LAETQADRQN VQG
//