LOCUS       SIU02433.1               415 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            lipase lipe protein.
ACCESSION   LT708304-3847
PROTEIN_ID  SIU02433.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="lipE"
                     /locus_tag="BQ2027_MB3804"
                     /note="Mb3804, lipE, len: 415 aa. Equivalent to Rv3775,
                     len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 415 aa overlap). Probable lipE,
                     hydrolase lipase (EC 3.1.-.-), equivalent to
                     Q9CD95|LIPE|ML0119 PROBABLE HYDROLASE from Mycobacterium
                     leprae (411 aa), FASTA scores: opt: 2418, E(): 6.4e-144,
                     (84.75% identity in 406 aa overlap). Also similar to other
                     esterases e.g. Q9ABH2|CC0255 ESTERASE A from Caulobacter
                     crescentus (374 aa), FASTA scores: opt: 427, E(): 2.4e-19,
                     (28.9% identity in 391 aa overlap); O87861|ESTA ESTERASE A
                     from Streptomyces chrysomallus (389 aa), FASTA scores:
                     opt: 417, E(): 1e-18, (31.0% identity in 361 aa overlap);
                     Q9RK50|SCF12.08 PUTATIVE ESTERASE from Streptomyces
                     coelicolor (376 aa), FASTA scores: opt: 385, E(): 1e-16,
                     (31.35% identity in 373 aa overlap); etc. Also similar to
                     proteins from Mycobacterium tuberculosis e.g.
                     P71778|Rv1497|MTCY277.19 HYPOTHETICAL 45.8 KDA PROTEIN
                     (429 aa), FASTA scores: opt: 457, E(): 3.5e-21, (30.4%
                     identity in 395 aa overlap). Protein product from Mb3804
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3804 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR001466"
                     /db_xref="InterPro:IPR012338"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y568"
BEGIN
        1 MRAGDGKIRV PADLDAVTAT GEEDHSEIDG AAVDRIWRAA RHWYRAGMHP AIQLCIRHHG
       61 RVVLNRAIGH GWGNAPTDEA DAEKIPVTTD TPFCVYSAAK AITATVVHML VERGHFALDD
      121 RVCEYLPSYT SHGKHRTTIR HVLTHSAGVP FPTGPRPDVR RADDHEYAVE RLGELRPLYR
      181 PGLVHIYHAL TWGPLMREIV YAATGKEIRE ILATEILDPL GFRWTNFGVA ERDVPLVAPS
      241 HATGRQLPPV IAAVFRKAIG GTVHEIIPYT NTPFFLSTIL PSSNTVSTAN ELSRFMEILR
      301 RGGELDGVRV LSPETLRGAV TECRRLRPDF ATGLMPLRWG TGFMLGSAKY GPFGRNAPAA
      361 FGHLGLVNIA VWADPERALS GGLISSGKPG RDPEAGRYGA LLNAITAEIP RASSG
//