LOCUS       SIU02429.1               353 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            HISTIDINOL-PHOSPHATE AMINOTRANSFERASE HISC2 (IMIDAZOLE
            ACETOL-PHOSPHATE TRANSAMINASE) (IMIDAZOLYLACETOLPHOSPHATE
            AMINOTRANSFERASE) protein.
ACCESSION   LT708304-3843
PROTEIN_ID  SIU02429.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="hisC2"
                     /locus_tag="BQ2027_MB3800"
                     /note="Mb3800, hisC2, len: 353 aa. Equivalent to Rv3772,
                     len: 353 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 353 aa overlap). Probable hisC2,
                     histidinol-phosphate aminotransferase (EC 2.6.1.9), highly
                     similar to Q9ZBY8|SCD78.11 PUTATIVE HISTIDINOL-PHOPHATE
                     AMINOTRANSFERASE from Streptomyces coelicolor (359 aa),
                     FASTA scores: opt: 1165, E(): 7.1e-64, (52.55% identity in
                     356 aa overlap); and similar to many e.g. Q9EYX2 from
                     Gardnerella vaginalis (317 aa) FASTA scores: opt: 814,
                     E(): 1.7e-42, (45.15% identity in 308 aa overlap);
                     Q9CMI7|HISH_1PM0838|HISH from Pasteurella multocida (365
                     aa), FASTA scores: opt: 701, E(): 1.5e-35, (35.05%
                     identity in 351 aa overlap); O07131|HIS8_METFL|HISC|HISH
                     from Methylobacillus flagellatum (368 aa), FASTA scores:
                     opt: 645, E(): 4e-32, (34.5% identity in 345 aa overlap);
                     etc. Contains PS00599 Aminotransferases class-II
                     pyridoxal-phosphate attachment site. BELONGS TO CLASS-II
                     OF PYRIDOXAL-PHOSPHATE-DEPENDENT AMINOTRANSFERASES.
                     COFACTOR: PYRIDOXAL PHOSPHATE. Protein product from Mb3800
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3800 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:Q7TVQ0"
                     /db_xref="InterPro:IPR001917"
                     /db_xref="InterPro:IPR004839"
                     /db_xref="InterPro:IPR005861"
                     /db_xref="InterPro:IPR015421"
                     /db_xref="InterPro:IPR015422"
                     /db_xref="InterPro:IPR015424"
                     /db_xref="InterPro:IPR024892"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TVQ0"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTARLRPELA GLPVYVPGKT VPGAIKLASN ETVFGPLPSV RAAIDRATDT VNRYPDNGCV
       61 QLKAALARHL GPDFAPEHVA VGCGSVSLCQ QLVQVTASVG DEVVFGWRSF ELYPPQVRVA
      121 GAIPIQVPLT DHTFDLYAML AAVTDRTRLI FVCNPNNPTS TVVGPDALAR FVEAVPAHIL
      181 IAIDEAYVEY IRDGMRPDSL GLVRAHNNVV VLRTFSKAYG LAGLRIGYAI GHPDVITALD
      241 KVYVPFTVSS IGQAAAIASL DAADELLART DTVVAERARV SAELRAAGFT LPPSQANFVW
      301 LPLGSRTQDF VEQAADARIV VRPYGTDGVR VTVAAPEEND AFLRFARRWR SDQ
//