LOCUS       SIU02419.1               475 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            two component sensor kinase tcry protein.
ACCESSION   LT708304-3833
PROTEIN_ID  SIU02419.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="tcry"
                     /locus_tag="BQ2027_MB3790C"
                     /note="Mb3790c, -, len: 475 aa. Equivalent to Rv3764c,
                     len: 475 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 475 aa overlap). Possible histidine
                     protein kinase (EC 2.7.3.-), part of a two-component
                     regulatory system, similar to others e.g.
                     Q9ADN6|2SC10A7.25 PUTATIVE TWO COMPONENT SYSTEM HISTIDINE
                     KINASE from Streptomyces coelicolor (524 aa), FASTA
                     scores: opt: 1332, E(): 5.4e-70, (49.9% identity in 477 aa
                     overlap); Q9L3C1|KB|CAC42479 PUTATIVE HISTIDINE KINASE
                     from Amycolatopsis mediterranei (469 aa), FASTA scores:
                     opt: 515, E(): 1.4e-22, (36.1% identity in 313 aa
                     overlap); P72560 HISTIDINE PROTEIN KINASE from
                     Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2)
                     (438 aa), FASTA scores: opt: 480, E(): 1.4e-20, (40.1%
                     identity in 232 aa overlap);
                     P30847|P76401|BAES_ECOLI|B2078 SENSOR PROTEIN from
                     Escherichia coli strain K12 (467 aa); etc. Also similar to
                     others from Mycobacterium tuberculosis e.g.
                     P96368|Rv1032c|MTCY10G2.17 (509 aa), FASTA scores: opt:
                     1007, E(): 4e-51, (43.5% identity in 416 aa overlap); and
                     P71815|Rv0758|MTCY369.03 (485 aa), FASTA scores: opt: 738,
                     E(): 1.6e-35, (28.6% identity in 438 aa overlap).
                     Equivalent to AAK48235 from Mycobacterium tuberculosis
                     strain CDC1551 (506 aa) but shorter 31 aa. Protein product
                     from Mb3790c detected using SWATH mass spectrometry.
                     Mb3790c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y574"
                     /db_xref="InterPro:IPR003594"
                     /db_xref="InterPro:IPR003660"
                     /db_xref="InterPro:IPR003661"
                     /db_xref="InterPro:IPR004358"
                     /db_xref="InterPro:IPR005467"
                     /db_xref="InterPro:IPR036097"
                     /db_xref="InterPro:IPR036890"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y574"
BEGIN
        1 MGITAATEMA LRRHLVAQLD NQLGGTSYRS VLMYPEKMPR PPWRRETHNY IRSGPGPRFL
       61 DAPGQPAGMV AAVVSDGTTV AAGYLTGSGS RAALTSTGRS QLERIAGSRT PLTLDLDGLG
      121 RYRVLAAPSR NGHDVIVTGL SMGNVDATML QMLIIFGIVT VIALVAATTA GIVIIKRALA
      181 PLRRVAQTAS EVVDLPLDRG EVKLPVRVPE PDANPSTEVG QLGSALNRML DHIAAALSAR
      241 QASETRVRQF VADASHELRT PLAAIRGYTE LTQRIGDDPE AVAHAMSRVA SETERITRLV
      301 EDLLLLARLD SGRPLERGPV DMSRLAVDAV SDAHVAGPDH QWALDLPPEP VVIPGDAARL
      361 HQVVTNLLAN ARVHTGPGTI VTTRLSTGPT HVVLQVIDNG PGIPAALQSE VFERFARGDT
      421 SRSRQAGSTG LGLAIVSAVV KAHNGTITVS SSPGYTEFAV RLPLDGWQPL ESSPR
//